Association between measures of obesity and colorectal adenoma

作     者：KIM You Joung LEE Kang-moon CHUNG Woo Chul PAIK Chang Nyol JUNG Sung Hoon 

作者机构：Division of Biostatistics Graduate School of Public Health Seoul National University Seoul 110-799 Korea 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第22期

页      面：3711-3715页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 12[管理学] 120203[管理学-旅游管理] 1202[管理学-工商管理] 07[理学] 08[工学] 

主　　题：body mass index colorectal adenoma obesity 

摘      要：Background Few studies have used body mass index （BMI）, waist-to-hip ratio （WHR） and waist circumference （WC） at the same time to investigate the association between obesity and colorectal adenoma. This study examined the strength of association between colorectal adenoma and obesity using not only BMI, but also WHR and WC. Methods Subjects of this study included 1322 asymptomatic patients who underwent colonoscopy for cancer screening from January 2006 to June 2008. Anthropometric measurements, blood test results, and a self-administered questionnaire from each subject were analyzed. Results Four hundred and fourteen adenoma cases were identified in 1322 subjects. Using univariate analysis, the prevalence of adenoma was associated with BMI and WHR and was higher among the abdominal obesity group using WC guidelines of the Korean Society for the Study of Obesity, but not using WC guidelines of the International Diabetes Federation. In multiple Logistic regression analysis, general obesity （BMI 〉25 kg/m2） increased the risk of colorectal adenoma （odds ratio （OR）, 1.43; 95% confidence interval （CO, 1.05-1.94）. Also, abdominal obesity by the WC cutoffs and the highest WHR percentile group （WHR 〉0.95） were significantly associated with adenoma. Among three measures of obesity, however, only BMI had a persistent association with adenoma after adjusting reciprocally for BMI, WC, and WHR （OR, 1.30; 95% CI, 1.02-1.80; and 1.49; 1.06-2.10, adjusted for WC and WHR, respectively）. Conclusion The data suggest that general obesity is associated with an increased risk of colorectal adenoma.