检索结果-南通市图书馆

Chemokine Receptor CXCR3 in the Spinal Cord Contributes to chronic itch in Mice

Neuroscience Bulletin 2018年第1期34卷 54-63页

作者： Peng-Bo Jing De-Li Cao Si-Si Li Meixuan Zhu Xue-Qiang Bai Xiao-Bo Wu Yong-Jing Gao Pain Research Laboratory Institute of Nautical MedicineJiangsu Key Laboratory of Neuroregeneration Nantong University Co-innovation Center of Neuroregeneration Nantong University

Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis （ACD）. CXCR3 in the spinal cord also con- tributes to the maintenance of neuropathic pain. However, whether spinal CXCR3 is involved in acute or chronic itch remains unclear. Here, we report that Cxcr3-/- mice showed normal scratching in acute itch models but reduced scratching in chronic itch models of dry skin and ACD. In contrast, both formalin-induced acute pain and complete Freund＇s adjuvant-induced chronic inflammatory pain were reduced in Cxcr3-/- mice. In addition, the expression of CXCR3 and CXCL10 was increased in the spinal cord in the dry skin model induced by acetone and diethyl ether followed by water （AEW）. Intrathecal injection of a CXCR3 antagonist alleviated AEW-induced itch. Further- more, touch-elicited itch （alloknesis） after compound 48/80 or AEW treatment was suppressed in Cxcr3-/- mice. Finally, AEW-induced astrocyte activation was inhibited in Cxcr3-/- mice. Taken together, these data suggest that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.

关键词： chronic itch Alloknesis Dry skin CXCR3 CXCL10 - Spinal cord

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Anterior Cingulate Cortex-to-Midbrain Projection Controls chronic itch in

引用

Neuroscience Bulletin 2023年第5期39卷 793-807页

作者： Ting-Ting Zhang Su-Shan Guo Hui-Ying Wang Qi Jing Xin Yi Zi-Han Hu Xin-Ren Yu Tian-Le Xu Ming-Gang Liu Xuan Zhao Department of Anesthesiology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghai 200025China Center for Brain Science of Shanghai Children's Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China

itch is an unpleasant sensation that provokes the desire to *** acute itch serves as a protec-tive system to warn the body of external irritating agents,chronic itch is a debilitating but poorly-treated clinical dis-ease leading to repetitive scratching and skin ***-ever,the neural mechanisms underlying the pathophysiol-ogy of chronic itch remain ***,we identified a cell type-dependent role of the anterior cingulate cortex(ACC)in controlling chronic itch-related excessive scratch-ing behaviors in ***,we delineated a neural circuit originating from excitatory neurons of the ACC to the ventral tegmental area(VTA)that was critically involved in chronic ***,we demonstrate that the ACC→VTA circuit also selectively modulated histaminergic acute ***,the ACC neurons were shown to predomi-nantly innervate the non-dopaminergic neurons of the *** together,our findings uncover a cortex-midbrain cir-cuit for chronic itch-evoked scratching behaviors and shed novel insights on therapeutic intervention.

关键词： sAnterior cingulate cortex chronic itch Ventral tegmental area-Chemogenetics Neural circuit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spinal IL-33/ST2 Signaling Contributes to chronic itch via Astroglial JAK2–STAT3 Cascade in Mice

Spinal IL-33/ST2 Signaling Contributes to Chronic Itch via A...

引用

中国神经科学学会第十二届全国学术会议

作者： Lixia Du Xueming Hu Wenqiang Cui Langyue Hu Yang Zhou Yanqing Wang Wenli Mi Department of Integrative Medicine and Neurobiology The Academy of Integrative Medicine School of Basic Medical Sciences Institutes of Brain Science Brain Science Collaborative Innovation Center State Key Laboratory of Medical Neurobiology Fudan University

Increasing evidence including our previous studies indicates that interleukin-33（IL-33） and its receptor ST2 contribute to spinal glial activation and chronic pain sensitization. The recent study showed the critical role of peripheral IL-33 in poison ivy induced chronic itch. But the role of spinal IL-33/ST2 signaling in chronic itch is unclear. In this study, the ST2 gene knockout（ST2-/-） mice showed substantial reductions in scratching in chronic itch models of allergic contact dermatitis（ACD） induced by DNFB, as well as dry skin induced by acetone and diethylether followed by water（AEW）. In the ACD mice, the expression of spinal IL-33 and ST2 was significantly increased. The increased IL-33 was predominantly distributed in oligodendrocytes and astrocytes, while ST2 mainly expressed in astrocytes. Further studies showed that in the ACD mice, the activation of astrocytes and the increased phosphorylation of the transducer and activator of transcription 3（STAT3）, an emerging and critical molecule associated with itch, were markedly attenuated by intrathecal administration of neutralizing anti-ST2 antibody or ST2 gene knockout. Moreover, intrathecal injection of AG490, an inhibitor of the STAT3 activator Janus kinase（JAK）, significantly reduced the scratching behavior in DNFBinduced ACD mice. The above results indicate that spinal IL-33/ST2 signaling contributes to chronic itch via activating the astroglial JAK2–STAT3 cascade which providing a potential therapeutic option for treating itch.

关键词： IL-33/ST2 signaling chronic itch Astrocytes JAK2-STAT3

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Modulation of Pain and itch by Spinal Glia

引用

Neuroscience Bulletin 2018年第1期34卷 178-185页

作者： Makoto Tsuda Department of Life Innovation Graduate School of Pharmaceutical Sciences Kyushu University Department of Molecular and System Pharmacology Graduate School of Pharmaceutical Sciences Kyushu University

chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord. Furthermore, an increasing body of evidence from models of chronic pain and itch has indicated that synaptic hyperexcitability in the spinal dorsal horn might not be a consequence simply of changes in neurons, but rather of multiple alterations in glial cells. Thus, understanding the key roles of glial cells may provide us with exciting insights into the mechanisms of chronicity of pain and itch, and lead to new targets for treating chronic pain and itch.

关键词： Neuropathic pain chronic itch Microglia Astrocytes Spinal dorsal horn

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The behavioral study on the interactional deterioration between itch and depression

The behavioral study on the interactional deterioration betw...

引用

中国神经科学学会第十二届全国学术会议

作者： Xiao-Dong WANG Gang YANG Yun-Qing LI Hui LI Department of Anatomy and K.K.Leung Brain Research Centre the Fourth Military Medical University

Objective To explore the behavioral characteristics of the interactional deterioration between itch and depression. Methods（1） The establishment of chronic itch model. Adult C57/Bl6 mice were weighed and divided into two groups randomly: the DNFB group and the acetone group. Firstly, the belly were shaved and given 100 μl DNFB（0.15%） for allergic sensitization. 7 days later, the neck were shaved and given 50 μl DNFB（0.15%） for five weeks. The scratching number was counted for 30 min, and the depression index was measured by forced swimming, splash test and tail suspension test. All the operations and tests were applied to the control group（only treated with acetone）.（2） The establishment of depression model. Adult C57/Bl6 mice were weighed and divided into chronic unpredicted mild stimulation（CMUS） group and control group. CMUS model was treated randomly with different stresses everyday: sleep deprivation, tail suspension, fasting, cage inclination, constraint, forced swimming. The control group were raised normally without any stresses. 28 days later, forced swimming, splash test, tail suspension test and spontaneous itch test were proceeded.（3） Depression plus itch model. Adult C57/Bl6 mice were divided into three groups（A, B, C） randomly. Group A received CMUS stimulation as well as chronic DNFB treatment for 14 days;Group B and group C received CMUS and DNFB treatment, respectively. Scratching number was compared between group A and C while depression index was compared between group A and group B.（4） Histamine or chloroquine was intracutaneously injected into the neck in both CMUS-treated and normally raised mice to elicit acute pruritus, and scratching number was counted to explore the effects of depression on acute pruritus. Results（1） Compared to the control group, the scratching number, immobility time in the forced swimming test and tail suspension test, and grooming number in the splash test were all significantly increased in the chronic itch model group

关键词： chronic itch depression histamine chloroquine interactional deterioration mice

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hierarchical specification of pruriceptors by Runt-domain transcription factor Runx1

Hierarchical specification of pruriceptors by Runt-domain tr...

引用

中国神经科学学会第十二届全国学术会议

作者： Lu Qi Chengcheng Huang Xiaohua Wu Yeqi Tao Jingjing Yan Tianyong Shi Cheng Cao Lu Han Mengsheng Qiu Qiufu Ma Zijing Liu Yang Liu Zhejiang Key Laboratory of Organ Development and Regeneration Institute of Life Sciences Hangzhou Normal University College of Life Sciences Zhejiang University Beijing Institute of Biotechnology Dana-Farber Cancer Institute Harvard Medical School Department of Neurobiology Harvard Medical School

The somatic sensory neurons in dorsal root ganglia(DRG) detect and transmit a diverse array of sensory modalities, such as pain, itch, cold, warm, touch and others. Recent genetic and single-cell RNA sequencing studies have revealed a group of DRG neurons that could be particularly relevant for acute and chronic itch information transmission. They express the natriuretic peptide type B(NPPB), as well as a cohort of receptors and neuropeptides that have been implicated in chronic itch manifestation, including the interleukin-31 receptor A(IL31 ra) and its co-receptor oncostatin M receptor(Osmr), the cysteinyl leukotriene receptor 2(Cysltr2), somatostatin and neurotensin. However, how these neurons are generated during development remains unclear. Here we report that Runx1 is required to establish all these molecular features of NPPB *** further show that while early embryonic Runx1 activity is required for the formation of NPPB cells, at later stages Runx1 switches to a genetic repressor and thus its downregulation becomes a prerequisite for proper development of these pruriceptors. This mode by Runx1 is analogous to that in controlling another group of pruriceptors that specifically express the chloroquine receptor Mrgpr A3. Finally, behavioral studies using both sexes of mice revealed marked deficits in processing acute and chronic itch in Runx1 conditional knockout mice, possibly attributable to impaired development of various pruriceptors.

关键词： chronic itch development NPPB pruriceptor Runx1 transcriptional regulation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：