An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in
作者机构：Department of AnesthesiologyShanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Anatomy and PhysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Center for Brain Science of Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2023年第39卷第5期
页 面：793-807页
核心收录：
学科分类：0402[教育学-心理学(可授教育学、理学学位）] 040203[教育学-应用心理学] 04[教育学]
基 金：supported by grants from the National Natural Science Foundation of China(81873787,81961128024,32170994,and 82201362) Shanghai Natural Science Foundation(18ZR1424800 and 20ZR1430000) a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05) the innovative research team of high-level local universities in Shanghai
主 题：sAnterior cingulate cortex Chronic itch Ventral tegmental area-Chemogenetics Neural circuit
摘 要：Itch is an unpleasant sensation that provokes the desire to *** acute itch serves as a protec-tive system to warn the body of external irritating agents,chronic itch is a debilitating but poorly-treated clinical dis-ease leading to repetitive scratching and skin ***-ever,the neural mechanisms underlying the pathophysiol-ogy of chronic itch remain ***,we identified a cell type-dependent role of the anterior cingulate cortex(ACC)in controlling chronic itch-related excessive scratch-ing behaviors in ***,we delineated a neural circuit originating from excitatory neurons of the ACC to the ventral tegmental area(VTA)that was critically involved in chronic ***,we demonstrate that the ACC→VTA circuit also selectively modulated histaminergic acute ***,the ACC neurons were shown to predomi-nantly innervate the non-dopaminergic neurons of the *** together,our findings uncover a cortex-midbrain cir-cuit for chronic itch-evoked scratching behaviors and shed novel insights on therapeutic intervention.
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