Modulation of Pain and Itch by Spinal Glia

作     者：Makoto Tsuda 

作者机构：Department of Life Innovation Graduate School of Pharmaceutical Sciences Kyushu University Department of Molecular and System PharmacologyGraduate School of Pharmaceutical Sciences Kyushu University 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2018年第34卷第1期

页      面：178-185页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by JSPS KAKENHI Grant Numbers 15H02522 the Core Research for Evolutional Science and Technology(CREST)program the Practical Research Project for Allergic Diseases and Immunology(Research on Allergic Diseases and Immunology)from Japan Agency for Medical Research and Development the Toray Science Foundation Takeda Science Foundation The Nakatomi Foundation 

主　　题：Neuropathic pain Chronic itch Microglia Astrocytes Spinal dorsal horn 

摘      要：Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord. Furthermore, an increasing body of evidence from models of chronic pain and itch has indicated that synaptic hyperexcitability in the spinal dorsal horn might not be a consequence simply of changes in neurons, but rather of multiple alterations in glial cells. Thus, understanding the key roles of glial cells may provide us with exciting insights into the mechanisms of chronicity of pain and itch, and lead to new targets for treating chronic pain and itch.