检索结果-南通市图书馆

Association of Estrogen Receptor-α Gene PvuII Polymorphisms with the Effect of calcium supplementation on Skeletal Development in Chinese Pubertal Girls

引用

Biomedical and Environmental Sciences 2009年第6期22卷 480-487页

作者： LI-CHEN YANG QIAN ZHANG JIAN-HUA PIAO ZHENG-WU HUANG XIAO-QI HU GUAN-SHENG MA Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100021 China

Objective To investigate the association of estrogen receptor alpha （ER-c0 PvulI polymorphisms with the effect of calcium supplementation on bone development in Chinese pubertal girls, and to study the importance of calcium supplementation by maximizing the peak bone mass at their pubertal stage for bone development and osteoporosis prevention and the role of estrogen in regulating bone mass. Methods Ninety-four pubertal girls were recruited in the study and divided into two groups and three sub-groups according to the ER-α PvulI polymorphisms. One year before and after calcium supplementation, bone mineral density （BMD） was measured by DEXA, while BGP, BAP, TRACP5b, and 25-OH-VitD3, as well as estrogen were detected by ELISA. Analysis of covariance was used to examine the effect of ER-ct polymorphisms on bone development. Results The absolute increase and percentage change of BGP were significantly higher in the supplemented group than in the control group （P〈0.05）. In the intervened group, The increase and percentage change of the total body and radio distal 1/3 BMD were higher in PP than in PP genotype （P〈0.05）, and the increase of BAP in Pp was also higher than PP in the same group （P〈0.05）. Conclusion PP genotype shows a better response to calcium supplementation than the other Pvull polymorphisms.

关键词： Pubertal girls PvulI polymorphisms calcium supplementation Skeletal development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes:A Randomized,Placebo-controlled,calcium supplementation Trial

引用

Biomedical and Environmental Sciences 2011年第3期24卷 243-248页

作者： YU Bo WU HongYing LI Fang GONG Jie ZHOU DunJin ZHANG ZhiFeng YANG XiaoGuang HUANG ZhenWu National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beo'ing 100021 China Department of Radiography Union Hospital Huazhong University of Science & Technology Wuhan 430022 Hubei China Wuhan Regional Center for Disease Control and Prevention Wuhan 430024 Hubei China

Objective To investigate the effect of calcium supplementation on bone mineral density （BMD） in Chinese women with different Fokl vitamin D receptor （VDR） genotypes （FF, Ff, and ff） after weaning or resumption of menstruation during lactation. Methods A total of 40 subjects with the same Fokl VDR genotype were randomly divided into two groups： one received calcium tablet （600 mg once daily as CaCO3） and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine （L2-L4） and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25（OH）VitD3, and serum estradiol were measured at weaning and I year thereafter. Results After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different Fokl VDR genotypes such as FF 〉 Ff 〉 ff （P〈O.05, 〈0.01, and 〈0.001, respectively）. BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype （P〈0.05）. Compared with the control group women with the FF genotype regained more BMD after calcium supplementation （P〈0.05）. Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.

关键词： Fokl VDR genotype calcium supplementation Bone mineral accretion after weaning Chinese women Low dietary calcium intake.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of calcium supplementation on severe hypocalcemia in patients with secondary hyperparathyroidism after total parathyroidectomy

引用

World Journal of Clinical Cases 2022年第13期10卷 4033-4041页

作者： Jun Liu Xue-Feng Fan Meng Yang Lin-Ping Huang Ling Zhang Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of General Surgery Shougang General HospitalShougang 553000Guizhou ProvinceChina Department of Nephrology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Severe hypocalcemia(SH)is a dreaded complication of total parathyroidectomy(TPTX)without *** To compare conventional and preventive calcium supplementation(CS)regimens in terms of SH occurrence after *** This retrospective study included patients who underwent TPTX between January 2015 and May 2018 at the China-Japan Friendship *** January 2015 to May 2016,conventional CS was performed in patients who underwent TPTX,with calcium amounts adjusted according to postoperative serum calcium *** October 2016 to May 2018,preventive CS was performed according to preoperative alkaline phosphatase(ALP)*** patients were defined as lowrisk(ALP500 U/L)for *** preoperative blood samples were collected in the fasting state on the day before *** blood samples were obtained at 6-7 AM from the first postoperative *** A total of 271 patients were *** patients were 47.7±11.1 years old,and 57.6%were *** mean body mass index(BMI)was 22.9±3.8 kg/m^(2).There were no significant differences in sex,age,BMI,preoperative ALP,serum calcium,serum phosphorus,calcium-phosphorus ratio,and intact parathyroid hormone(iPTH)between the two CS *** with conventional CS,preventive CS led to lower occurrence rates of hypocalcemia within 48 h(46.0%vs 74.5%,P<0.001)and SH(31.7%vs 64.1%,P<0.001).Multivariable analysis showed that preoperative iPTH levelsodds ratio(OR)=1.001,95%confidence interval(CI:1.000-1.001,P=0.009),preoperative ALP amounts(OR=1.002,95%CI:1.001-1.003,P=0.002),preoperative serum phosphorus levels(OR=8.729,95%CI:1.518-50.216,P=0.015)and preventive CS(OR=0.132,95%CI:0.067-0.261,P<0.001)were independently associated with *** patients with preoperative ALP≥500 U/L,only preventive CS(OR=0.147,95%CI:0.038-0.562.P=0.005)was independently associated with *** This study suggests that preventive CS could reduce the occurrence of SH,indica

关键词： End-stage renal disease Secondary hyperparathyroidism Parathyroidectomy Hypocalcemia calcium supplementation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

calcium deficiency： where does the diagnostic criterion come from and by what is bone health influenced？

引用

Chinese Medical Journal 2014年第24期127卷 4161-4163页

作者： Fang Aiping Li Keji Department of Nutrition and Food Hygiene Peking University Health Science Center Beijing 100191 China

Dietary surveys suggest that a considerable proportion of the population fail to consume recommended amounts of calcium m both developing and developed countries. Recommended allowance for dietary calcium has attracted many controversies and there are discrepant opinions on how to meet the recommendations in the global scientific community.

关键词： calcium deficiency diagnostic criterion calcium supplementation bone health recommended dietary allowances

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PRIMARY AND SECONDARY PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS WITH HORMONE REPLACEMENT THERAPY

PRIMARY AND SECONDARY PREVENTION OF POSTMENOPAUSAL OSTEOPORO...

引用

The Third International Congress on Osteoporosis

作者： Martina Dren King’s College Hospital Department of Obstetrics ＆ Gynecology

＜正＞A substantial number of postmenopausal women are estimated to have osteoporosis according to the WHO *** deficiency is one major risk factor for osteoporosis in women of all *** the decade following menopause most women experience more rapid and primarily cancellous bone loss than that predicted by aging *** trials demonstrate a positive impact of estrogen on bone density, considered to reflect fracture risk,in particular at the spine and *** greatest impact on bone mineral density is associated with daily doses of 2 mg estradiol,0.625 mg conjugated estrogens,and 1.25 mg *** estradiol 50μg administered by patch and tibolone 2.5 mg seem to be of similar effectiveness given the relatively small body of evidence according to a recent *** doses of these compounds have limited,but also measurable effects on bone mineral *** data for estradiol gel suggest a role for daily doses of 1-2 *** do at least not impair the action of estrogen, additional benefits cannot be *** calcium supplements,regarded as beneficial for bone health,allow for a regular dose reduction of the estrogen has not been adequately *** of observational studies suggest that ever use of estrogen replacement decreases the risk for hip fracture by 25 %.Most often estrogen replacement is initiated in the perimenopause given its potential to relief climacteric symptoms,which are most common in early ***,the optimal onset and desirable duration of hormone replacement therapy to prevent osteoporosis are currently *** studies suggest a benefit of estrogen therapy for bone mass independent of *** studies in elderly women are urgently needed to find the optimal time frame of estrogen therapy and its various modalities recognizing the generally low patients’ acceptance of the concept to use estrogen for many years to prevent a potential disease at old age not

关键词： androgens bisphosphonates bone mineral density calcium supplementation estrogen(hormone)replacement therapy fracture postmenopausal osteoporosis progestins selective estrogen receptor modulators vitamin D

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：