PRIMARY AND SECONDARY PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS WITH HORMONE REPLACEMENT THERAPY
作者单位：King’s College HospitalDepartment of Obstetrics ＆ Gynecology
会议名称：《The Third International Congress on Osteoporosis》
会议日期：1999年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：androgens bisphosphonates bone mineral density calcium supplementation estrogen(hormone)replacement therapy fracture postmenopausal osteoporosis progestins selective estrogen receptor modulators vitamin D
摘 要：正A substantial number of postmenopausal women are estimated to have osteoporosis according to the WHO *** deficiency is one major risk factor for osteoporosis in women of all *** the decade following menopause most women experience more rapid and primarily cancellous bone loss than that predicted by aging *** trials demonstrate a positive impact of estrogen on bone density, considered to reflect fracture risk,in particular at the spine and *** greatest impact on bone mineral density is associated with daily doses of 2 mg estradiol,0.625 mg conjugated estrogens,and 1.25 mg *** estradiol 50μg administered by patch and tibolone 2.5 mg seem to be of similar effectiveness given the relatively small body of evidence according to a recent *** doses of these compounds have limited,but also measurable effects on bone mineral *** data for estradiol gel suggest a role for daily doses of 1-2 *** do at least not impair the action of estrogen, additional benefits cannot be *** calcium supplements,regarded as beneficial for bone health,allow for a regular dose reduction of the estrogen has not been adequately *** of observational studies suggest that ever use of estrogen replacement decreases the risk for hip fracture by 25 %.Most often estrogen replacement is initiated in the perimenopause given its potential to relief climacteric symptoms,which are most common in early ***,the optimal onset and desirable duration of hormone replacement therapy to prevent osteoporosis are currently *** studies suggest a benefit of estrogen therapy for bone mass independent of *** studies in elderly women are urgently needed to find the optimal time frame of estrogen therapy and its various modalities recognizing the generally low patients’ acceptance of the concept to use estrogen for many years to prevent a potential disease at old age not