Association of Estrogen Receptor-α Gene PvuII Polymorphisms with the Effect of Calcium Supplementation on Skeletal Development in Chinese Pubertal Girls

作     者：LI-CHEN YANG QIAN ZHANG JIAN-HUA PIAO ZHENG-WU HUANG XIAO-QI HU GUAN-SHENG MA 

作者机构：Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100021 China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2009年第22卷第6期

页      面：480-487页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 071010[理学-生物化学与分子生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0905[农学-畜牧学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 

基　　金：supported by the Nutrition Research Funding of the Chinese Nutrition Society 2004 

主　　题：Pubertal girls PvulI polymorphisms Calcium supplementation Skeletal development 

摘      要：Objective To investigate the association of estrogen receptor alpha （ER-c0 PvulI polymorphisms with the effect of calcium supplementation on bone development in Chinese pubertal girls, and to study the importance of calcium supplementation by maximizing the peak bone mass at their pubertal stage for bone development and osteoporosis prevention and the role of estrogen in regulating bone mass. Methods Ninety-four pubertal girls were recruited in the study and divided into two groups and three sub-groups according to the ER-α PvulI polymorphisms. One year before and after calcium supplementation, bone mineral density （BMD） was measured by DEXA, while BGP, BAP, TRACP5b, and 25-OH-VitD3, as well as estrogen were detected by ELISA. Analysis of covariance was used to examine the effect of ER-ct polymorphisms on bone development. Results The absolute increase and percentage change of BGP were significantly higher in the supplemented group than in the control group （P〈0.05）. In the intervened group, The increase and percentage change of the total body and radio distal 1/3 BMD were higher in PP than in PP genotype （P〈0.05）, and the increase of BAP in Pp was also higher than PP in the same group （P〈0.05）. Conclusion PP genotype shows a better response to calcium supplementation than the other Pvull polymorphisms.