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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 235-236页

作者： Nawaphon Saelim Khemjira Suksawaeng Jutamat Chupan Isariya Techatanawat The Government Pharmaceutical Organization

Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence(BE)testing for approval of immediate release(IR)solid dosage forms containing moxifloxacin hydrochloride as the API manufactured by the Government Pharmaceutical Organization(GPO)are *** solubility of moxifloxacin hydrochloride determined by the shake flask method in six different pH mediums(1.2,4.5,5.4,6.4,6.8 and 7.5)was 4.988±0.1962,27.012±0.4138,21.668±0.5165,47.200±0.8095,73.438±1.7310 and 196.475±4.4624 mg/mL,*** Dose/Solubility(D/S)Ratio of the highest strength(400 mg)available in the market of moxifloxacin tablets was 80.192,14.808,18.460,8.475,5.447 and 2.036 mL,respectively.

关键词： Moxifloxacin hydrochloride biopharmaceutics classification system(BCS) Permeability Solubility Biowaiver

A MICROCOMPUTER PROGRAM PACKAGE FOR PHARMACOKINETICS AND biopharmaceutics

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医学研究生学报 1989年第3期2卷 1-5页

作者：杨友春陈刚李可深 Computer centre Department of PharmacologyJinling Hospital

In this paper, a microcomputer program package for pharmacokinetics and biopharmaceutics (PKBP) was presented. This package is applicable to various calculations for pharmacokinetics and biopharmaceutics. Some mathema... 详细信息

关键词： Microcomputer Program Package Pharmacokinetics biopharmaceutics

Metal-organic frameworks for advanced drug delivery

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2362-2395页

作者： Siyu He Li Wu Xue Li Hongyu Sun Ting Xiong Jie Liu Chengxi Huang Huipeng Xu Huimin Sun Weidong Chen Ruxandra Gref Jiwen Zhang Center for Drug Delivery Systems Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Institut de Sciences Moléculaires D'Orsay UniversitéParis-SaclayOrsay Cedex 91400France Key Laboratory of Modern Chinese Medicine Preparations Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China School of Pharmaceutical Sciences Anhui University of Chinese MedicineHefei 230012China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Metal-organic frameworks(MOFs),comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous,crystalline *** tunable porosity,chemical composition,size and shape,and easy surface functionalization make this large family more and more popular for drug *** is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical *** article presents an overall review and perspectives of MOFs-based drug delivery systems(DDSs),starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ***,the synthesis and characterization of MOFs for DDSs are developed,followed by the drug loading strategies,applications,biopharmaceutics and quality ***,a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics,diseases therapy and advanced *** particular,the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be ***,challenges in MOFs development for DDSs are discussed,such as biostability,biosafety,biopharmaceutics and nomenclature.

关键词： Metal-organic frameworks Drug loading Drug delivery systems Synthesis and characterization Diseases therapy Pharmaceutics biopharmaceutics Biosafety

Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy

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Green Chemical Engineering 2023年第2期4卷 173-188页

作者： Xiaobin Li Junyu Liu Haihong Chen Yaxin Chen Yi Wang Can Yang Zhang Xin-Hui Xing Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Institute of Biochemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China MOE Key Laboratory for Industrial Biocatalysis Beijing100084China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing100084China

With the rapid development of chemical engineering and biotechnology,polypeptide,as a promising candidate in the biomedical field,has been thoroughly investigated and extensively used as the drug delivery vehicle for diseases treatment,especially cancer,owing to the high biocompatibility,good biodegradability,versatile con-structions,and diverse *** polypeptide-based drug delivery system(so-called EPP-DDS)can deliver the cargos to the target site via a specific recognition effect,followed by overcoming the barriers like blood brain barrier(BBB)and releasing them by responding to the microenvironment cues,to improve the therapeutic efficacy and reduce the ***,it's of great importance to conclude and summarize the updates on EPP-DDS developed by chemical engineering *** this review,we first summarized the recent updates in the manufacturing of polypeptide and preparation of EPP-DDS based on green biochemical engineering and/or synthetic processes for cancer therapy,including chemotherapy,immunotherapy,photodynamic therapy(PDT),gene therapy,and combination ***,we surveyed the research progress of inflammation-mediated cancer treatment strategies based on EPP-DDS with high anti-inflammation ***,we concluded the discovery and green production process of engineered polypeptide,challenges,and perspectives of ***,the EPP-DDS has great potential for cancer therapy in the clinic with improved therapeutic efficacy and reduced adverse effect,which needs the innovation of green biochemical engineering for customized design and production of polypeptides.

关键词： Polypeptide Drug delivery system Cancer therapy biopharmaceutics Green biochemical engineering

The History of Pharmacokinetics in Cuba： Role of Universities

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Journal of Pharmacy and Pharmacology 2014年第8期2卷 453-469页

作者： Eduardo Manuel Femandez-Sanchez Jorge Duconge Department of Pharmacology and Toxicology Institute of Pharmacy and Foods Havana 17100 Cuba Pharmaceutical Sciences Department School of Pharmacy University of Puerto Rico Medical Sciences Campus Puerto Rico009365067 United States

A university is a higher academic institution with a mission to educate individuals in order to help nations reach their developmental goals. It implies teaching innovative disciplines through the most advanced scientific and pedagogical methods, in harmony with recent international standards and national needs. Some of these innovative disciplines turn out to be a valuable driving-force of the transformation in a country. An example of such transforming disciplines is the PK （pharmacokinetics） in Cuba, considered by many as exclusive of developed countries, it shows significant contributions to the current success of the local biopharmaceutical industry, and particularly to the scientific achievements of several biotechnological centers. Noteworthily, the academic activities and scientific work performed at the UH （University of Havana） and other colleges across the Island are closely related to this success. While passing through the different stages of transformation at academic institutions in the country, we discuss herein the most significant milestones in the history of the Pharmacokinetics in Cuba.

关键词： University pharmacokinetics biopharmaceutics teaching biotechnology.