Metal-organic frameworks for advanced drug delivery

作     者：Siyu He Li Wu Xue Li Hongyu Sun Ting Xiong Jie Liu Chengxi Huang Huipeng Xu Huimin Sun Weidong Chen Ruxandra Gref Jiwen Zhang Siyu He;Li Wu;Xue Li;Hongyu Sun;Ting Xiong;Jie Liu;Chengxi Huang;Huipeng Xu;Huimin Sun;Weidong Chen;Ruxandra Gref;Jiwen Zhang

作者机构：Center for Drug Delivery SystemsShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of SciencesBeijing 100049China Institut de Sciences Moléculaires D'OrsayUniversitéParis-SaclayOrsay Cedex 91400France Key Laboratory of Modern Chinese Medicine PreparationsMinistry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China School of Pharmaceutical SciencesAnhui University of Chinese MedicineHefei 230012China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical ExcipientsNational Institutes for Food and Drug ControlBeijing 100050China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第8期

页      面：2362-2395页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the National Key R&D Program of China(No.2020YFE0201700) National Nature Science Foundation of China(No.81773645) a public grant overseen by the French National Research Agency(ANR),France as part of the“Investissements d’Avenir”program(Labex NanoSaclay:ANR-10-LABX-0035,France) 

主　　题：Metal-organic frameworks Drug loading Drug delivery systems Synthesis and characterization Diseases therapy Pharmaceutics Biopharmaceutics Biosafety 

摘      要：Metal-organic frameworks(MOFs),comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous,crystalline *** tunable porosity,chemical composition,size and shape,and easy surface functionalization make this large family more and more popular for drug *** is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical *** article presents an overall review and perspectives of MOFs-based drug delivery systems(DDSs),starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ***,the synthesis and characterization of MOFs for DDSs are developed,followed by the drug loading strategies,applications,biopharmaceutics and quality ***,a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics,diseases therapy and advanced *** particular,the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be ***,challenges in MOFs development for DDSs are discussed,such as biostability,biosafety,biopharmaceutics and nomenclature.