Multi-functional engineered polypeptide-based drug delivery systems for improved cancer therapy

作     者：Xiaobin Li Junyu Liu Haihong Chen Yaxin Chen Yi Wang Can Yang Zhang Xin-Hui Xing Xiaobin Li;Junyu Liu;Haihong Chen;Yaxin Chen;Yi Wang;Can Yang Zhang;Xin-Hui Xing

作者机构：Institute of Biopharmaceutical and Health EngineeringShenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing100084China MOE Key Laboratory for Industrial BiocatalysisBeijing100084China Institute of Biomedical Health Technology and EngineeringShenzhen Bay LaboratoryShenzhen440300China Center for Synthetic and Systems BiologyTsinghua UniversityBeijing100084China 

出 版 物：《Green Chemical Engineering》 (绿色化学工程（英文）)

年 卷 期：2023年第4卷第2期

页      面：173-188页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the Scientific Research Startup Funds(No.QD2021020C)at Shenzhen International Graduate School at Tsinghua University the grant from the Shenzhen Science and Technology Innovation Commission(No.KCXFZ20201221173207022) 

主　　题：Polypeptide Drug delivery system Cancer therapy Biopharmaceutics Green biochemical engineering 

摘      要：With the rapid development of chemical engineering and biotechnology,polypeptide,as a promising candidate in the biomedical field,has been thoroughly investigated and extensively used as the drug delivery vehicle for diseases treatment,especially cancer,owing to the high biocompatibility,good biodegradability,versatile con-structions,and diverse *** polypeptide-based drug delivery system(so-called EPP-DDS)can deliver the cargos to the target site via a specific recognition effect,followed by overcoming the barriers like blood brain barrier(BBB)and releasing them by responding to the microenvironment cues,to improve the therapeutic efficacy and reduce the ***,it s of great importance to conclude and summarize the updates on EPP-DDS developed by chemical engineering *** this review,we first summarized the recent updates in the manufacturing of polypeptide and preparation of EPP-DDS based on green biochemical engineering and/or synthetic processes for cancer therapy,including chemotherapy,immunotherapy,photodynamic therapy(PDT),gene therapy,and combination ***,we surveyed the research progress of inflammation-mediated cancer treatment strategies based on EPP-DDS with high anti-inflammation ***,we concluded the discovery and green production process of engineered polypeptide,challenges,and perspectives of ***,the EPP-DDS has great potential for cancer therapy in the clinic with improved therapeutic efficacy and reduced adverse effect,which needs the innovation of green biochemical engineering for customized design and production of polypeptides.