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Melanin-based nanoparticles in biomedical applications:From molecular imaging to treatment of diseases

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Chinese Chemical Letters 2019年第3期30卷 533-540页

作者： Xinyu Wang Jie Sheng Min Yang Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine The First Clinical Medical College Nanjing Medical University

Melanin nanoparticles(MNPs) is a kind of natural nanomaterial, not only retain the inherent characteristics of melanin(metal ion chelation, photothermal conversion property, etc.) but also can exhibit more excellent properties, such as high dispersion stability, good biocompatibility and biodegradability. Furthermore, these performances can be enhanced to target the specific sites and treat diseases by the surface modification or combination with functional substance. All these advantages of MNPs made it an ideal platform for developing biomedical applications. In this paper, the MNPs preparation methods were summarized first. biomedical applications of MNPs were also reviewed,including molecular imaging(magnetic resonance, positron emission tomography, and photoacoustic imaging) and treatment of diseases(drug delivery, photothermal therapy, antioxidant therapy, and iron overload therapy). Further development and prospects of MNPs for practice in biology or medicine were also discussed.

关键词： Melanin Nanoparticles Imaging Drug delivery biomedical application

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Recent advances of flexible sensors for biomedical applications

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Progress in Natural Science:Materials International 2021年第6期31卷 872-882页

作者： Guozhen Shen State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences

Ultrathin, soft, flexible and stretchable sensors offer good opportunity to design personal health diagnosis and treatment systems by fabricating wearable biomedical devices for continuous health monitoring and preventive medicine. This paper summarizes the recent advances of flexible sensors for next generation biomedical applications. Materials used for flexible sensors are first briefly introduced. Followed to this part, the latest developments of flexible sensors for biomedical applications are discussed in detail, including flexible sensors for skin-attached devices and implantable devices. Finally, the challenges and future research directions of flexible sensors are also discussed in the development of biomedical devices.

关键词： Flexible electronics Sensors biomedical Electronic skins

Recent Advance of Tellurium for biomedical Applications

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Chemical Research in Chinese Universities 2020年第4期36卷 551-559页

作者： WANG Hengliang CHAI Luxiao XIE Zhongjian ZHANG Han International Collaborative Laboratory of 2D Materials for Optoelectwnic Science and Technology Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060P.R.China Shenzhen International Institute for biomedical Research Shenzhen 518116P.R.China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Institute of Microscale Optoelectwnics and Otolaryngology Departmentand Biobank of the First Affiliated HospitalShenzhen Second People's HospitalHealth Science CenterShenzhen UniversityShenzhen 518060P.R.China

Tellurium(Te)nanomaterials have aroused a wide interest in semiconductor,thermoelectric,piezoelectric,as well as biomedical applications.The last decades of reports indicated a major nanostructure of one-dimensional(ID)Te on account of its inherent structural anisotropy.Two-dimenional(2D)Te has been newly developed and drawn a lot of interests recently.This review presents the intrinsic biological potential of Te-based nanomaterials and summarizes their up-to-date advance in phototherapy and reactive oxygen species(ROS)-related applications in the biomedical field.

关键词： Tellurium Nanostructure biomedical application

Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

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Chronic Diseases and Translational Medicine 2019年第2期5卷 75-88页

作者： Chun-Song Hu Qing-Hua Wu Da-Yi Hu Tengiz Tkebuchava Jiangxi Academy of Medical Science Hospital of Nanchang University Nanchang University Nanchang Jiangxi 330006 China Institute of Cardiovascular Diseases Nanchang University Nanchang Jiangxi 330006 China Department of Cardiology People's Hospital of Peking University Beijing 100044 China Department of Cardiology Tongji University School of Medicine Shanghai 200032 China Boston TransTec LLC Boston MA 02459 USA

Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes administration of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and aldosterone antagonists, to biomedical engineering methods, which include interventional engineering, such as percutaneous balloon mitral valvotomy, percutaneous coronary intervention, catheter ablation, biventricular pacing or cardiac resynchronization therapy (CRT) and CRT-defibrillator use, and implantable cardioverter defibrillator use;mechanical engineering, such as left ventricular assistant device use, internal artery balloon counteq^ulsation, cardiac support device use, and total artificial heart implantation;surgical engineering, such as coronary artery bypass graft, valve replacement or repair of rheumatic or congenital heart diseases, and heart transplantation (HT);regenerate engineering, which includes gene therapy, stem cell transplantation, and tissue engineering;and rehabilitating engineering, which includes exercise training, low-salt diet, nursing, psychological interventions, health education, and external counterpulsation/enhanced external counterpulsation in the outpatient department. These biomedical engineering therapies have greatly improved the symptoms of CHF and life expectancy. To date, pharmacotherapy, which is based on evidence-based medicine, large-scale, multi-center, randomized controlled clinical trials, is still a major treatment option for CHF;the current interventional and mechanical device engineering treatment for advanced CHF is not enough owing to its individual status. In place of HT or the use of a total artificial heart, stem cell technology and gene therapy in regenerate engineering for CHF are very promising. However, each therapy has its advantages and disadvantages, and it is currently possible to select better therapeutic strategies for patients with CHF accord

关键词： Chronic heart failure biomedical engineering Treatment

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Mechanical and corrosion behaviour of hydroxyapatite reinforced Mg-Sn alloy composite by squeeze casting for biomedical applications

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Journal of Magnesium and Alloys 2020年第2期8卷 452-460页

作者： R Radha D.Sreekanth School of Mechanical and Building Sciences Vellore Institute of TechnologyChennai 600127India

Magnesium alloys have gained increasing attention for biomedical applications due to their biocompatibility and the biodegradability.Hydroxyapatite(HA)is known to be a highly bioactive because of its similar chemical and crystallographic structures to bone.Therefore,HA is believed to be a potential ceramic material for the fabrication of Mg based composites,to combine the advantages of both Mg and HA.But,in general,the composites known to be more susceptible to corrosion attack than the matrix alloy.Hence,in the present work,Sn is used as an alloying element to evaluate its effect on mechanical as well as corrosion properties of Mg/HA composites.Mg with 5 wt%HA and Mg-1 wt%Sn-5 wt%HA composites were prepared separately by stir assisted squeeze casting route.The phase analysis and microstructure were characterized by X-ray diffraction(XRD)and scanning electron microscope(SEM)coupled with energy dispersive spectroscopy(EDS)respectively.Mechanical properties were evaluated by conducting the compression and micro hardness tests.Corrosion properties of as-cast composites were studied by linear polarization,Tafel and electrochemical impedance spectroscopy(EIS)techniques.The results of both XRD and SEM-EDS revealed that the main constitutional phases of as-cast Mg/HA composites were a-Mg and HA whereas,in Mg-Sn/HA composites,the phase Mg^Sn was observed along with fine distribution of HA particles.In both the cases,no interfacial reactions observed.The yield strength,ultimate compression strength and hardness were found to be increased with the addition of Sn in Mg/HA composites.Furthermore,the addition of Sn also played an important role in increasing the corrosion resistance of the Mg/HA composites which was attributed the refinement of grain size and the formation of Mg2Sn phase along the grain boundaries.Hence,it was concluded that the addition of Sn improves both mechanical and corrosion properties of Mg/HA composites.

关键词： Magnesium Composite biomedical Corrosion Squeeze casting

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Theory,simulations and the design of functionalized nanoparticles for biomedical applications:A Soft Matter Perspective

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npj Computational Materials 2017年第1期3卷 52-66页

作者： Stefano Angioletti-Uberti Department of Materials Imperial College LondonLondon SW72AZUK Beijing Advanced Innovation Centre for Soft Matter Science and Engineering Beijing University of Chemical Technology100099 BeijingPR China

Functionalised nanoparticles for biomedical applications represents an incredibly exciting and rapidly growing field of research.Considering the complexity of the nano-bio interface,an important question is to what extent can theory and simulations be used to study these systems in a realistic,meaningful way.In this review,we will argue for a positive answer to this question.Approaching the issue from a“Soft Matter”perspective,we will consider those properties of functionalised nanoparticles that can be captured within a classical description.We will thus not concentrate on optical and electronic properties,but rather on the way nanoparticles’interactions with the biological environment can be tuned by functionalising their surface and exploited in different contexts relevant to applications.In particular,we wish to provide a critical overview of theoretical and computational coarsegrained models,developed to describe these interactions and present to the readers some of the latest results in this fascinating area of research.

关键词： functional meaningful biomedical

Comprehensive Physicochemical Profiling and Characterization of Neem Plant Leaf Extracts: Insights for Pharmaceutical & biomedical Applications

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化学工程与科学期刊(英文) 2023年第4期13卷 382-399页

作者： Martin Nduka Nwanekezie Julius Nnamdi Ndive Ijeoma Love Ogbonna Godspower O. Sebe Department of Chemical Engineering Chukwuemeka Odumegwu Ojukwu University Uli Nigeria Department of Chemical Chemistry and Biomedical Engineering University of New Haven West Haven USA

This study presents a comprehensive physicochemical analysis of neem plant leaf extracts with a focus on their potential applications in pharmaceutical and biomedical contexts. Utilizing the soxhlet extraction method with n-hexane as the solvent, the study investigated the quantitative and qualitative composition of neem leaf extracts in reference to concentrations. The results revealed a diverse array of compounds, including cyanogenic glycoside, cardiac glycoside, tannin, steroids, phytate, flavone, oxalate, rutin, lunamarin, catechin, spatein, naringin, resveratrol, kaempferol, flavonones, epicatechin, and epihedrine, with notable concentrations. Further analyses indicated shared physicochemical properties, such as carboxyl and hydroxyl groups. Qualitative assessments affirmed the presence of flavonoid and phenolic compounds, while FTIR analysis confirmed the existence of carboxyl and hydroxyl groups. These findings emphasize the potential use of neem leaves as pharmaceutical raw materials due to their antioxidant-rich content. Additionally, the study explored the density, viscosity, saponification value, and foaming power of neem leaf extracts, providing insights into their industrial applicability. GC-MS analyses highlighted the presence of significant chemical compounds, with potential therapeutic implications. Mineral analysis demonstrated essential elements for human and animal nutrition. This study underscores neem plant leaves’ multifaceted potential across pharmaceutical, herbal medicine, cosmetic, and functional food sectors. It lays a solid foundation for further research into the specific health benefits, offering valuable insights for harnessing neem leaves’ potential in innovative products and treatments.

关键词： Phytochemical N-Hexane Neem Leaves FTIR Pharmaceutical Biomedicine biomedical Antioxidant Chemical Herbal

Introduction to the Special Issue on Advances in Biophotonics and biomedical Optics

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 1-2页

作者： Polina Dyachenko(Timoshina) Tingting Yu Dan Zhu Valery V.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Britton Chance Center for biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P.R.China MoE Key Laboratory for biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Wuhan 430074 P.R.China

The 9th Chinese-Russian Workshop on Biopho-tonics and biomedical Optics was held online on 28-30 September 2020.The bilateral workshop brought together both Russian and Chinese scientists,engineers,and clinical researchers from a variety of disciplines engaged in applying optical science,photonics,and imaging technologies to problems in biology and medicine.During the workshop,2 ple-nary lectures,35 invited presentations,5 oral pre-sentations,and 8 internet reports were presented.This special issue selects some papers from the attendees and includes both research and review articles.

关键词： photonics Russian biomedical

A special issue on biomedical Photonics

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Frontiers of Optoelectronics 2015年第2期8卷 119-121页

作者： Dan ZHU Britton Chance Center for biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Ministry of Education (MoE) Key Laboratory for biomedical Photonics Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan 430074 China National Researc-h Saratov State University. Saratov 410012 Russia Institute of Precise Mechanics and Control RAS Saratov 410028 Russia Interdisciplinary Laboratory of Biophotonics National Research Tomsk State University Tomsk 634050 Russia

During the last decades, there have been significant developments in the field of biomedical photonics. We are pleased to present a special issue of Frontiers of Optoelectronics on biomedical Photonics, which assembles one letter, three reviews, and eight original research articles. Optical coherence tomography （OCT） has the ability to image tissues in vivo. Polarization-sensitive optical coherence tomography （PSOCT） is a functional extension of OCT. By measuring the polarization state of light reflecting or scattering back from tissue, PSOCT enables depth-resolved mapping of sample polarization information, such as phase-retardation and optical axis orientation. In this issue, Zhenyang Ding et al. gave a review of technology developments and biomedical applications of PSOCT. Fourier domain optical coherence tomography （FDOCT） provides cross-sectional images of tissuematerial microstructures by spectral analysis of the low-coherence interference fringe pattern. Zhihua Ding et al. developed two novel systems with ultralong depth range. One is the orthogonal dispersive spectral domain optical coherence tomography （SDOCT）, and the other is the recirculated swept source interferometer/OCT. No compromise between depth range and depth resolution is required in both systems. With their SDOCT system, Jian Gao et al. imaged mouse model with dorsal skin window chamber, they obtained a series of real-time OCT images and reconstructed 3D images of the specific area inside the dorsal skin window chamber by Amira.

关键词： Photoelectricity Skin window Three-Dimensional Images functional expansion biomedical Optic axis aluminium depth resolution Photonics optical coherence tomography