Melanin-based nanoparticles in biomedical applications:From molecular imaging to treatment of diseases

作     者：Xinyu Wang Jie Sheng Min Yang 

作者机构：Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine The First Clinical Medical College Nanjing Medical University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第3期

页      面：533-540页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：financial support from the National Natural Science Foundation of China (Nos. 31671035, 51473071, 51803082) Natural Science Foundation of Jiangsu Province(No. BK20170204) Jiangsu Provincial Medical Innovation Team (No. CXTDA2017024) Innovation Capacity Development Plan of Jiangsu Province (No. BM2018023) Jiangsu Provincial Key Medical Discipline (No. ZDXKA2016017) 

主　　题：Melanin Nanoparticles Imaging Drug delivery Biomedical application 

摘      要：Melanin nanoparticles(MNPs) is a kind of natural nanomaterial, not only retain the inherent characteristics of melanin(metal ion chelation, photothermal conversion property, etc.) but also can exhibit more excellent properties, such as high dispersion stability, good biocompatibility and biodegradability. Furthermore, these performances can be enhanced to target the specific sites and treat diseases by the surface modification or combination with functional substance. All these advantages of MNPs made it an ideal platform for developing biomedical applications. In this paper, the MNPs preparation methods were summarized first. Biomedical applications of MNPs were also reviewed,including molecular imaging(magnetic resonance, positron emission tomography, and photoacoustic imaging) and treatment of diseases(drug delivery, photothermal therapy, antioxidant therapy, and iron overload therapy). Further development and prospects of MNPs for practice in biology or medicine were also discussed.