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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Surface Characterization and Tribology Behavior of PMMA Processed by Excimer Laser

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Chinese Journal of Mechanical Engineering 2023年第5期36卷 45-61页

作者： Dong Qin Juan Guo Ming Liang Ling Chen Weimin He Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610000China Ophthalmology Department The Third People’s Hospital of ChengduChengdu 610031China

Polyoxymethylene methacrylate (PMMA) is widely used in ophthalmic biomaterials. Misuse of PMMA in extreme environments is likely to damage the ocular surface and intraocular structures. The surface characterization and tribological behavior of PMMA processed using an excimer laser were investigated in this study by contrasting diferent lubrication conditions and friction cycles. The results show that the roughness of the material surface increases with laser processing, which changes its physical structure. Under lubrication, the laser-treated PMMA exhibits better hydrophilicity, especially during the use of eye drops. No obvious relationship exists between the laser-processing time and friction behavior. However, the laser treatment may contribute to the formation of friction and wear mechanisms of PMMA materials. Laser-treated PMMA in saline solution exhibits better abrasive resistance by showing a lower wear rate than that in eye drops, although it has a higher friction coefcient. In this study, the diferent friction stages in laser-treated PMMA were clarifed under two lubrication conditions. The wear rates of the laser-treated PMMA were found to decrease with the number of cycles, and the friction coefcient has a similar variation tendency. The wear behavior of the laser-treated PMMA is dominated by the main abrasive wear and secondary transferred flm formation. This study provides a theoretical basis for the development and application of ophthalmic biomaterials in complex environments by examining the material surface interface behavior and wear mechanism after laser processing using PMMA as the research matrix.

关键词： biocompatible materials Poly(methyl methacrylate) Surface characterization Tribology behavior

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Tissue engineering approaches for dental pulp regeneration:The development of novel bioactive materials using pharmacological epigenetic inhibitors

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Bioactive materials 2024年第10期40卷 182-211页

作者： Ross M.Quigley Michaela Kearney Oran D.Kennedy Henry F.Duncan Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College Dublin(TCD)University of DublinLincoln PlaceDublinIreland Department of Anatomy and Regenerative Medicine and Tissue Engineering Research GroupRoyal College of Surgeons in Ireland(RCSI)University of Medicine and Health SciencesDublinIreland The Trinity Centre for Biomedical Engineering(TCBE)and the Advanced materials and Bioengineering Research Centre(AMBER) Royal College of Surgeons in Ireland(RCSI)and Trinity College Dublin(TCD)DublinIreland

The drive for minimally invasive endodontic treatment strategies has shifted focus from technically complex and destructive root canal treatments towards more conservative vital pulp ***,novel approaches to maintaining dental pulp vitality after disease or trauma will require the development of innovative,biologicallydriven regenerative medicine *** example,cell-homing and cell-based therapies have recently been developed in vitro and trialled in preclinical models to study dental pulp *** approaches utilise natural and synthetic scaffolds that can deliver a range of bioactive pharmacological epigenetic modulators(HDACis,DNMTis,and ncRNAs),which are cost-effective and easily applied to stimulate pulp tissue ***,many biological factors hinder the clinical development of regenerative therapies,including a lack of blood supply and poor infection control in the necrotic root canal *** challenges include a need for clinically relevant models and manufacturing challenges such as scalability,cost concerns,and regulatory *** review will describe the current state of bioactive-biomaterial/scaffold-based engineering strategies to stimulate dentine-pulp regeneration,explicitly focusing on epigenetic modulators and therapeutic pharmacological *** will highlight the components of dental pulp regenerative approaches,describe their current limitations,and offer suggestions for the effective translation of novel epigenetic-laden bioactive materials for innovative therapeutics.

关键词： Epigenetics Regenerative medicine Regenerative endodontics biocompatible materials Tissue engineering

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IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER

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Chinese Journal of Polymer Science 1997年第2期15卷 180-186页

作者：计剑封麟先邱永兴俞小洁杨士林 Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027

A new reactive graft copolymer, poly(tetramethylene glycol)-graft-omega-propyl sodium sulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesized by the cationic polymerization of alpha-omega-bifunctional PEG macromonomer ((sic)CH2-PEG-CH2CH2CH2SO3Na) and THF. The obtained copolymer exhibits the expected structure as indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine) were covalently attached to the copolymer after converting the sulfonate group, to sulfonyl chloride. So the new reactive graft copolymer (PTMG-g-PEG-CH2CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.

关键词： potentially bioactive moieties polyether biocompatible materials

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Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up

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Bioactive materials 2022年第11期7卷 439-456页

作者： Barzi Gareb Nico Bvan Bakelen Leon Driessen Pieter Buma Jeroen Kuipers Dirk W.Grijpma Arjan Vissink Ruud R.M.Bos Baucke van Minnen University of Groningen University Medical Center GroningenDepartment of Oral and Maxillofacial SurgeryHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands Radboud University Medical Center Radboud Institute for Molecular Life SciencesOrthopaedic Research LabHoutlaan 46525 XZP.O.Box 91026500 HCNijmegenthe Netherlands University of Groningen University Medical Center GroningenDepartment of Biomedical Sciences of Cells and SystemsHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands University of Twente TechMed CentreDepartment of Biomaterials Science and TechnologyDrienerlolaan 57522 NBP.O.Box 2177500 AEEnschedethe Netherlands

pplying biodegradable osteosyntheses avoids the disadvantages of titanium osteosyntheses. However, foreign-body reactions remain a major concern and evidence of complete resorption is lacking. This study compared the physico-chemical properties, histological response and radiographs of four copolymeric biodegradable osteo-synthesis systems in a goat model with 48-months follow-up. The systems were implanted subperiosteally in both tibia and radius of 12 Dutch White goats. The BioSorb FX [poly(70LLA-co-30DLLA)], Inion CPS [poly([70–78.5] LLA-co-[16–24]DLLA-co-4TMC)], SonicWeld Rx [poly(DLLA)], LactoSorb [poly(82LLA-co-18GA)] systems and a negative control were randomly implanted in each extremity. Samples were assessed at 6-, 12-, 18-, 24-, 36-, and 48-month follow-up. Surface topography was performed using scanning electron microscopy (SEM). Differential scanning calorimetry and gel permeation chromatography were performed on initial and explanted samples. Histological sections were systematically assessed by two blinded researchers using (polarized) light microscopy, SEM and energy-dispersive X-ray analysis. The SonicWeld Rx system was amorphous while the others were semi-crystalline. Foreign-body reactions were not observed during the complete follow-up. The SonicWeld Rx and LactoSorb systems reached bone percentages of negative controls after 18 months while the BioSorb Fx and Inion CPS systems reached these levels after 36 months. The SonicWeld Rx system showed the most predictable degradation profile. All the biodegradable systems were safe to use and well-tolerated (i.e., complete implant replacement by bone, no clinical or histological foreign body reactions, no [sterile] abscess formation, no re-interventions needed), but nanoscale residual polymeric fragments were observed at every system’s assessment.

关键词： biocompatible materials Absorbable implants Polymers Orthopaedic fixation devices Reconstructive surgical procedures Fracture fixation

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Preface for the special issue on regenerative medical materials

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Frontiers of materials Science 2014年第1期8卷 1-2页

作者： Shengmin Zhang (1) Rizhi Wang (2) 1. Huazhong University of Science and Technology Huazhong China2. The University of British Columbia Vancouver Canada

Biomaterials science is undoubtedly at the frontier of materials science and engineering. It bridges materials science with biology and medicine, and more importantly its progress brings direct impact to improving health and quality of life for many of us. Traditionally, biomedical implants are made from common engineering materials to replace human tissues or organs. A good example is the artificial joints made of cobalt-chromium alloy, titanium alloy, and high density polyethylene. Over 1 million total hip arthroplasties are performed annually in North America. They effectively relieve pain and restore mobility of those suffering from osteoarthritis and osteoporosis. Other well-known biomedical implants developed in the 20th century are dental implants, artificial heart valves, coronary stents, and artificial hearts. Although effective in achieving the functions, these biomaterials share the same drawback： they are inert and do not actively interact with the surrounding tissues. The injured tissues or organs are replaced permanently by non-viable materials without the possibility of regeneration.

关键词： artificial heart materials Science and Engineering Total Joint Replacement biocompatible materials Inert Distress Medicine materials science medical materials human tissue Regenerative Organ High Density Polyethylene Engineering materials Osteoarthritis

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Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2

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World Journal of Gastroenterology 2001年第1期7卷 143-148页

作者： Edgar Staren Takeshi Iwamura Hubert Appert John Howard Department of Surgery Medical College of Ohio Toledo Ohio USA Department of Surgery Miyazaki Medical College Miyazaki Japan

INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10].

关键词： Carcinoma Pancreatic Neoplasms Taxoids Antineoplastic Agents, Phytogenic biocompatible materials Collagen Drug Combinations Drug Resistance, Multiple Drug Resistance, Neoplasm Fluorescent Dyes Humans In Vitro Laminin Neoplasm Invasiveness P-Glycoprotein Paclitaxel derivatives Phenotype Proteoglycans RNA, Neoplasm Research Support, Non-U.S. Gov't Rhodamine 123 Tumor Cells, Cultured

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Progress in various crosslinking modification for acellular matrix

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Chinese Medical Journal 2014年第17期127卷 3156-3164页

作者： Yang Haitang Tan Qiang Zhao Heng Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiaotong University Shanghai 200030 China Shanghai Lung Cancer Clinic Center Shanghai Chest HospitalShanghai Jiaotong University Shanghai 200030. China

Objective To review the current crosslinking strategies for acelluar matrix scaffold,laying the foundation for subsequent *** sources Data were mainly obtained from recent papers published in PubMed or indexed by Web of Science,with keyword like *** Various crosslinking strategies,including chemical,physical and biological methods,have been introduced to facilitate the performance of fresh acellular *** crosslinking reagents,involved in synthetic and naturally derived agents,need to be eliminated before implantation in case of their potential biotoxicity,although several crosslinking agents with less toxicity and specific characteristics have been *** crosslinking methods present to be safe,additive-free and relatively controllable for rapid surface functionalization with no consideration of remaining *** crosslinking strategies have attracted great interest,and have been demonstrated to enhance collagen-based crosslinking since their preparations do not need toxic or potentially biologically contaminated substances and can be carried out under physiological *** Kinds of crosslinking methods with its potential advantages have been developed to modify raw acelluar matrix,of which the performance are promising after being crosslinked by several crosslinking *** preclinical and clinical evaluations should be taken to vertify their safety and efficacy for the tissues and organs substitutes in tissue and regenerative medicine.

关键词： acellular dermis biocompatible materials cross-linking reagents tissue engineering

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Biocompatibility of KLD-12 Peptide Hydrogel as a Scaffold in Tissue Engineering of Intervertebral Discs in Rabbits

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第2期30卷 173-177页

作者：孙建华郑启新吴永超刘郁东郭晓东伍卫刚 Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Orthopedics the First Affiliated Hospital of Shihezi University

KLD-12 peptide with a sequence of AcN-KLDLKLDLKLDL-CNH2 was synthesized and its biocompatibility was assessed in animals. Rabbit MSCs were cultured in the hydrogel for 2 weeks. Live cells were counted by using Calcein-AM/P1 fluorescence staining. MTT was employed to assess the viability of MSCs cultured in KLD-12 peptide solution of 0.01%, 0.03%, and 0.05%. Hemolysis test, skin irritation test and implantation test were conducted to evaluate its biocompatibility with host tissues. Our results demonstrated that the MSCs in hydrogel grew well and maintained round shape. Cell survival rate was 92.15% （mean： 92.15%±1.17%） at the 7th day and there was no difference in survival rate between day 7 and day 14. Cell proliferation test showed that the A value of the KLD-12 solutions was not significantly different from that of control groups （complete culture media）（P〉0.05） at the 24th and 48th h. The hemolysis rate of KLD-12 solution was 0.112%. Skin irritation test showed that the skin injected with KLD-12 solution remained normal and the score of skin irritation was 0. The histological examination with HE staining exhibited that the skin layers were clear and there was no infiltration with neutrophilic granulocytes and lymphocytes. It is concluded that KLD-12 peptide hydrogel bad a good biocompatibility with host rabbit and MSCs, and KLD-12 pep- tide hydrogel can provide an appropriate microenvironment for MSCs.

关键词： peptide self-assembly biocompatible materials intervertebral disc

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Rationalizing the Development of Biomaterials with A New Way of Thinking

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Chinese Journal of Integrative Medicine 2011年第11期17卷 870-872页

作者：萧聪明 College of Material Science and Engineering Huaqiao University

The history of biomaterials research is seriously surveyed. It is found that an immutable way of thinking for developing biomaterials is rooted deeply in Western medicine and biology. It is necessary to modify or change the current status of thinking. In this paper, the author presents an idea to research and develop biomaterials via a combined way of thinking, i.e., combining together the wisdom and knowledge of Western medicine, Chinese medicine, and other disciplines.

关键词： biomaterials biocompatible materials Chinese medicine thinking

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