IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER

作     者：计剑 封麟先 邱永兴 俞小洁 杨士林 

作者机构：Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：1997年第15卷第2期

页      面：180-186页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China and Huoyindong Education Foundation 

主　　题：potentially bioactive moieties polyether biocompatible materials 

摘      要：A new reactive graft copolymer, poly(tetramethylene glycol)-graft-omega-propyl sodium sulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesized by the cationic polymerization of alpha-omega-bifunctional PEG macromonomer ((sic)CH2-PEG-CH2CH2CH2SO3Na) and THF. The obtained copolymer exhibits the expected structure as indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine) were covalently attached to the copolymer after converting the sulfonate group, to sulfonyl chloride. So the new reactive graft copolymer (PTMG-g-PEG-CH2CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.