Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2

作     者：Edgar Staren Takeshi Iwamura Hubert Appert John Howard 

作者机构：Department of Surgery Medical College of Ohio Toledo Ohio USA Department of Surgery Miyazaki Medical College Miyazaki Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2001年第7卷第1期

页      面：143-148页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported in part by phone-Poulenc Rorer Pharmaceuticals INC 

主　　题：Carcinoma Pancreatic Neoplasms Taxoids Antineoplastic Agents, Phytogenic Biocompatible Materials Collagen Drug Combinations Drug Resistance, Multiple Drug Resistance, Neoplasm Fluorescent Dyes Humans In Vitro Laminin Neoplasm Invasiveness P-Glycoprotein Paclitaxel derivatives Phenotype Proteoglycans RNA, Neoplasm Research Support, Non-U.S. Gov't Rhodamine 123 Tumor Cells, Cultured 

摘      要：INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10].