Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2
Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2作者机构:Department of Surgery Medical College of Ohio Toledo Ohio USA Department of Surgery Miyazaki Medical College Miyazaki Japan
出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))
年 卷 期:2001年第7卷第1期
页 面:143-148页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:Supported in part by phone-Poulenc Rorer Pharmaceuticals INC
主 题:Carcinoma Pancreatic Neoplasms Taxoids Antineoplastic Agents, Phytogenic Biocompatible Materials Collagen Drug Combinations Drug Resistance, Multiple Drug Resistance, Neoplasm Fluorescent Dyes Humans In Vitro Laminin Neoplasm Invasiveness P-Glycoprotein Paclitaxel derivatives Phenotype Proteoglycans RNA, Neoplasm Research Support, Non-U.S. Gov't Rhodamine 123 Tumor Cells, Cultured
摘 要:INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10].