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The Impact of Seasonal Variation on Clinical Pregnancy and Live Birth Rates in assisted reproductive technology: A Retrospective Cohort Study in Hainan

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Journal of Clinical and Nursing Research 2024年第8期8卷 243-250页

作者： Jingjing Zhong Zhiyong Lu Ning Ma Zhi Zhou Hui Lu Yejuan Li Jiajia Hu Bangbei Wan Jin Huang Anguo Wang Hailing Ruan Liqiang Zhaol Weiying Lu reproductive Medical Center Hainan Women and Children’s Medical CenterHaikou 570100Hainan ProvinceChina reproductive Medical Center Peking University Third HospitalBeijing 100000China

Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan ***:Patients were categorized into four groups based on the dates of artificial insemination and transplantation:spring,summer,autumn,or *** main outcome measures were clinical pregnancy rates and live birth *** outcomes included body mass index(BMI),oocyte number,two pronuclei(2PN)cleavage rate,total gonadotropin(Gn)dosage and days,age,2PN fertilization rate,sperm concentration,sperm PR rate,anti-Müllerian hormone(AMH),and endometrial *** semen quality indicators included sperm PR rate,total sperm count,sperm concentration,and total sperm ***:This retrospective cohort study analyzed 2,016 artificial insemination cycles and 1,783 ovarian retrieval cycles from January 2017 to October 2022,and assessed the semen quality of 6,651 outpatients from May 2017 to October *** artificial insemination cycles,sperm PR rate and clinical pregnancy rate were highest in winter,with a statistically significant difference between groups(P<0.05).Clinical pregnancy rate was influenced by both age and sperm PR rate(P<0.05).In ovarian retrieval cycles,the winter group had significantly higher clinical pregnancy,2PN fertilization,and 2PN cleavage rates than the other *** autumn group had higher live birth rates,though not significantly ***,winter months showed higher total sperm concentration and total sperm number compared to other ***:Seasonality affected clinical pregnancy and live birth rates in artificial insemination cycles but not in ovarian retrieval cycles in the Hainan *** findings suggest that while there is no need to choose a specific season for ovarian retrieval cycles,artificial insemination in winter may be preferable for patients.

关键词： Endocrinology assisted reproductive technology Seasonality Pregnancy rate Artificial insemination

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Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology

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Asian Journal of Andrology 2022年第3期24卷 260-265页

作者： Tian-Ying Yang Ying Chen Guo-Wu Chen Yi-Si Sun Zhi-Chao Li Xiao-Rong Shen Yi-Ni Zhang Wen He Dan Zhou Hui-Juan Shi Ai-Jie Xin Xiao-Xi Sun Shanghai Ji Ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of PharmacyFudan UniversityShanghai 200032China Shanghai Key Laboratory of Female reproductive Endocrine Related Diseases Shanghai 200011China Department of Endocrinology and reproductive Medicine Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China

Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies(ART).So far,the clinical evaluation of embryo quality depends on embryo ***,the clinical pregnancy rate is still ***,new indicators are needed to further improve the evaluation of embryo *** studies have shown that the decrease of sperm-specific protein actin-like 7A(ACTL7A)leaded to low fertilization rate,poor embryo development,and even *** aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo *** this study,excluding the factors of severe female infertility,a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization(IVF)laboratory *** results indicated that the ACTL7A levels were significantly reduced in sperm samples presenting poor embryo ***,the protein levels showed a significant correlation with fertilization outcomes of ***7A has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo *** conclusion,sperm-specific protein ACTL7A has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.

关键词： actin-like 7A assisted reproductive technology biomarker embryo quality in‑vitro fertilization outcomes

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An artificial intelligence model for embryo selection in preimplantation DNA methylation screening in assisted reproductive technology

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Biophysics Reports 2023年第6期9卷 352-361页

作者： Jianhong Zhan Chuangqi Chen Na Zhang Shuhuai Zhong Jiaming Wang Jinzhou Hu Jiang Liu Institute of Biophysics Chinese Academy of Science Guangdong Women's and Children's Hospital Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital Dongguan People's Hospital University of the Chinese Academy of Science School of Future technology University of the Chinese Academy of Science

Embryo quality is a critical determinant of clinical outcomes in assisted reproductive technology(ART).A recent clinical trial investigating preimplantation DNA methylation screening(PIMS) revealed that whole genome DNA methylation level is a novel biomarker for assessing ART embryo quality. Here, we reinforced and estimated the clinical efficacy of PIMS. We introduce PIMS-AI, an innovative artificial intelligence(AI) based model, to predict the probability of an embryo producing live birth and subsequently assist ART embryo selection. Our model demonstrated robust performance, achieving an area under the curve(AUC) of 0.90 in cross-validation and 0.80 in independent testing. In simulated embryo selection, PIMS-AI attained an accuracy of 81% in identifying viable embryos for patients. Notably,PIMS-AI offers significant advantages over conventional preimplantation genetic testing for aneuploidy(PGT-A), including enhanced embryo discriminability and the potential to benefit a broader patient population. In conclusion, our approach holds substantial promise for clinical application and has the potential to significantly improve the ART success rate.

关键词： assisted reproductive technology DNA methylation Artificial intelligence Embryo selection

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Impacts of assisted reproductive technology on perinatal outcomes and offspring health

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reproductive and Developmental Medicine 2023年第1期7卷 56-63页

作者： Hong Jin Yi-Juan Sun Yi-Min Shu Department of Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665 Kongjiang RoadShanghai 200092China Department of Genetics and IVF Shanghai Ji Ai Genetics and IVF InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Division of reproductive Endocrinology and Infertility Women and Infants Hospital/The Warren Alpert Medical School of Brown UniversityRI 02903USA

assisted reproductive technology(ART)has evolved rapidly over the last 40 years,offering hope to individuals and couples struggling with *** technology continues to evolve,simulating a realistic female reproductive system environment has become a common goal for all types of ARTs,thereby reducing the impact of the artificial microenvironment on perinatal and offspring *** this review,we provide a brief history of the development of each major ART and discuss the impact of ART on perinatal and offspring *** also explore how the negative consequences of ART may be overcome and how its benefits can be maximized.

关键词： assisted reproductive technology Perinatal outcomes Offspring health

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Embryo quality and chromosomal abnormality in embryos from couples undergoing assisted reproductive technology using preimplantation genetic screening

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亚太生殖杂志：英文版 2023年第1期12卷 16-22页

作者： Mina Niusha Seyed Ali Rahmani Leila Kohan Ladan Sadeghi Mohammad Nouri Hamid Reza Nejabati Department of Biology Arsanjan BranchIslamic Azad UniversityArsanjanIran Department of Medical Genetics Tabriz University of Medical SciencesTabrizIran Department of reproductive Biology Faculty of Advanced Medical SciencesTabriz University of Medical Sciences TabrizIran Department of Biochemistry and Clinical Laboratories Faculty of MedicineTabriz University of Medical SciencesTabrizIran

Objective:To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo ***:In this study,359 embryos from 62 couples were screened for chromosomes 13,21,18,X,and Y by fluorescence insitu *** biopsy of blastomere,a laser was used to remove a significantly smaller portion of the zona *** blastomere was gently biopsied by an aspiration pipette through the *** biopsy,the embryo was immediately returned to the embryo scope until *** integrity and blastocyst formation were assessed on day ***:Totally,282 embryos from 62 couples were *** chromosomes were normal in 199(70.57%)embryos and abnormal in 83(29.43%)*** was no significant association between the quality of embryos and numerical chromosomal abnormality(P=0.67).Conclusions:Embryo quality is not significantly correlated with its genetic ***,the quality of embryos determined by morphological parameters is not an appropriate method for choosing embryos without these abnormalities.

关键词： assisted reproductive technology Preimplantation genetic screening Aneuploidy Fluorescence insitu hybridization Chromosomal abnormalities Embryo quality Blastomere Blastocyst

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Influence of assisted reproductive technology and uterine leiomyoma on pregnancy outcomes in women with adenomyosis

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 56-59页

作者： Yi-Ling Wang Zhao Tian Xiao-Hong Chang Hong-Lan Zhu Heng Cui Department of Obstetrics and Gynecology People's HospitalPeking UniversityBeijing100044China

Aim To assess whether adverse pregnancy outcomes in women with adenomyosis are different according to the method of conception and the concurrent of uterine leiomyoma(UL).Methods We performed a retrospective ***-three singleton pregnancy cases complicated with adenomyosis were included in this *** the study group,15 women became pregnant with assisted reproductive technology(ART)and 21 women combined with *** outcomes were compared between ART and non-ART,UL and non-UL *** The prevalence for such complications as hypertensive disorder complicating pregnancy(HDCP)and postpartum hemorrhage(PPH)were significantly higher in the women conceived by ART(33.3%vs.5.3%,P=0.023)and(53.3%vs.23.7%,P=0.037),*** women concurrent with UL of which the diameter≥4cm were more likely to have severe PPH(44.4%vs.0%,P=0.021).Conclusion ART may increase the risk of adverse pregnancy outcomes such as HDCP and PPH in women with adenomyosis and UL of which the diameter≥4cm may further increase the risk of severe PPH.

关键词： Adenomyosis Adverse pregnancy outcomes assisted reproductive technology Uterine leiomyoma

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Cerebral palsy in children born after assisted reproductive technology: a meta-analysis

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World Journal of Pediatrics 2021年第4期17卷 364-374页

作者： Fang-Fang Wang Tao Yu Xiao-Lu Chen Rong Luo De-Zhi Mu Department of Pediatrics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Pediatrics West China Second University HospitalSichuan University20 South Renmin Road 3rd SectionWuhou DistrictChengdu 610041China Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education Sichuan UniversityChengduChina

Background Several studies have assessed the association between cerebral palsy(CP)and assisted reproductive technology(ART),but the results remain *** conducted a meta-analysis to evaluate the risk of CP after ART compared with natural conceptions and to examine CP risk separately in ART singletons,multiples and preterm *** Web-based databases(PubMed,Embase,the Cochrane Library,and Web of Science)were searched until November 22,*** which compare CP rates after ART with natural conceptions were *** Newcastle–Ottawa Scale was used to assess the quality of the included *** estimates were extracted and combined using the fixed-effects or random-effects model depending on the heterogeneity *** There were nine studies included in the *** included studies were of moderate or high quality.A significantly higher risk of CP[odds ratio(OR)=2.17,95%confidence interval(CI)1.72–2.74]was found in ART children(n=89,214)compared with naturally conceived children(n=4,160,745).The significantly higher risk decreased when data were restricted to singletons(OR=1.36,95%CI 1.16–1.59)and disappeared when data were restricted to multiples(OR=1.05,95%CI 0.86–1.29)or preterm births(OR=1.53,95%CI 0.66–3.56).Subgroup and sensitivity analyses indicated that the overall results were *** The risk of CP is increased more than two-fold after *** increased risk is largely due to increased rates of multiple birth and preterm delivery in ART children.

关键词： assisted reproductive technology Cerebral palsy Meta-analysis

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Support from Healthcare Professionals for Couples/Partners Undergoing assisted reproductive technology in Japan: A Literature Review

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Open Journal of Nursing 2023年第12期13卷 875-889页

作者： Mikio Watanabe Naohiro Hohashi Division of Family Health Care Nursing Graduate School of Health Sciences Kobe University Kobe Japan

Background and Purpose: A growing number of couples/partners have been undergoing assisted reproductive technology (ART) in Japan. The purpose of this study was to clarify the support from healthcare professionals based on the support vectors in the Family Care/Caring Theory proposed by Hohashi (2015) through a literature review. Methods: Using Ichushi-Web, we searched for original articles using the keywords “assisted reproductive technology”, “infertility”, “family”, “couple”, “nursing”, “care”, and “support”. Thirteen articles suitable for the purpose of this study were subjected to content analysis. Family support was encoded and grouped into subcategories and categories, and classified according to support vectors. Results: A total of 21 categories of support from healthcare professionals was extracted. Intervention for family internal environment included seven categories, such as “Nursing professionals stay close to females”. Intervention for family system unit included five categories, such as “Nursing professionals adjust couple/partner relationships”. Intervention for micro system only included “Nursing professionals provide opportunities for peer support to the couples/partners” and intervention for macro system only included “Nursing professionals encourage medical doctors to relate to females”. Intervention for family chrono environment included seven categories, such as “Healthcare professionals resolve female’s anxieties”. Conclusion: The support from healthcare professionals could be organized by the support vectors of Family Care/Caring Theory, but intervention for supra system (culture, religion, etc.) was lacking. Moreover, because most support was directed toward females or couples/partners, male-focused direct and/or indirect support are also needed. .

关键词： assisted reproductive technology Infertility Family Support Family Care/Caring Theory Literature Review

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Outcome of conservative treatment and subsequent assisted reproductive technology for patients with early-stage endometrial adenocarcinoma and poor fertility potential

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Chinese Medical Journal 2012年第19期125卷 3578-3580页

作者： TONG Xiao-mei ZHU Hai-yan LIN Xiao-na JIANG Ling-ying XU Wei-hai LIU Liu ZHANG Song-ying assisted Reproduction Unit Department of Obstetrics and GynecologySir Run Run Shaw HospitalZhejiang UniversityZhejiangHangzhouZhejiang 310016China

Conservative treatment with high doses of progestin is an alternative to standard hysterectomy for young patients with early-stage endometrial adenocarcinoma who desire to preserve their fertility. Here we report a patient with well-differentiated early-stage endometrial adenocarcinoma and poor fertility potential who failed to become pregnant in two in vitro fertilization-embryo transfer cycles and suffered a relapse after conservative treatment. This case illustrates that assessment of fertility potential is critical at the time of initial evaluation and conservative treatment planning for patients with endometrial adenocarcinoma.

关键词： endometrial carcinoma progestin assisted reproductive technology

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Effects of Luteinizing Hormone Supplementation on Ovarian Response and assisted reproductive technology Outcomes in Antagonist In vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: A Meta-analysis

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reproductive and Developmental Medicine 2019年第2期3卷 89-96页

作者： Lei Chen Cai-Rong Chen Xue-Jian Kong Cheng-Ran Qiu Center for reproductive Medicine The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Department of Neurology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Department of Gynecology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China

Objective:The study objective was to investigate the effects of luteinizing hormone(LH)supplementation on ovarian response and assisted reproductive technology(ART)outcomes in in vitro fertilization/intracytoplasmic sperm injection cycles with a gonadotropin(Gn)-releasing hormone antagonist ***:This is a meta-analysis,and nine published randomized controlled trials(1,685 patients)were *** data were extracted in the form of mean±standard deviation and population size,whereas dichotomous data were extracted in the form of odds ***:The total amount of follicle-stimulating hormone(FSH)used,the duration of stimulation(DOS),the number of eggs in MII stage,the total number of formed embryos,the clinical pregnancy rate,and live birth rates were similar between groups,but the estrogen level on the day of human chorionic Gn(hCG)administration was slightly higher in the LH supplementation *** subgroup analysis,it was reported that the addition of LH could significantly increase estrogen levels on the day of hCG administration in patients older than 35 years,and LH supplementation starting on the day of FSH administration may slightly extend the ***,regardless of the timing of LH supplementation,an increase in estrogen levels was found on the day of hCG ***:LH supplementation of an antagonist protocol increases estrogen levels on the day of hCG administration,but does not increase the number of mature oocytes retrieved,and also fails to improve ART outcomes.

关键词： assisted reproductive technology Gonadotropin-Releasing Hormone Antagonist Protocol Luteinizing Hormone Supplementation Meta-Analysis

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