Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology

作     者：Tian-Ying Yang Ying Chen Guo-Wu Chen Yi-Si Sun Zhi-Chao Li Xiao-Rong Shen Yi-Ni Zhang Wen He Dan Zhou Hui-Juan Shi Ai-Jie Xin Xiao-Xi Sun Tian-Ying Yang;Ying Chen;Guo-Wu Chen;Yi-Si Sun;Zhi-Chao Li;Xiao-Rong Shen;Yi-Ni Zhang;Wen He;Dan Zhou;Hui-Juan Shi;Ai-Jie Xin;Xiao-Xi Sun

作者机构：Shanghai Ji Ai Genetics and IVF InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies)School of PharmacyFudan UniversityShanghai 200032China Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesShanghai 200011China Department of Endocrinology and Reproductive MedicineObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2022年第24卷第3期

页      面：260-265页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by the Foundation of Shanghai Municipal Health Commission(No.202140340) National Natural Science Foundation of China(No.82171603) Foundation of Science and Technology Commission of Shanghai Municipality(No.17JC1400902,No.20Z21900402) 

主　　题：actin-like 7A assisted reproductive technology biomarker embryo quality in‑vitro fertilization outcomes 

摘      要：Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies(ART).So far,the clinical evaluation of embryo quality depends on embryo ***,the clinical pregnancy rate is still ***,new indicators are needed to further improve the evaluation of embryo *** studies have shown that the decrease of sperm-specific protein actin-like 7A(ACTL7A)leaded to low fertilization rate,poor embryo development,and even *** aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo *** this study,excluding the factors of severe female infertility,a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization(IVF)laboratory *** results indicated that the ACTL7A levels were significantly reduced in sperm samples presenting poor embryo ***,the protein levels showed a significant correlation with fertilization outcomes of ***7A has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo *** conclusion,sperm-specific protein ACTL7A has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.