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Journal of Traditional Chinese Medicine 2021年第4期41卷 600-607页

作者： LAI Qingzhong ZHANG Xianjie CHEN Meilan HAN Zhicun Department of Chinese Medical Massage Zhejiang Integrated Traditional and Western Medicine HospitalHangzhou 310003China Department of Orthopedics Jinhua First People's Hospital of Wucheng districtJinhua 321075China Department of Acupuncture Tongde Hospital of Zhejiang ProvinceHangzhou 310012China

OBJECTIVE:This study investigated the effect of salvia miltiorrhiza-asarum ointment(SMAO)plus Chinese medical massage on knee osteoarthritis in a rat ***:Hulth's method was used to establish a Sprague-Dawley rat model of knee osteoarthritis(OA).The levels of matrix metalloproteinase-13(MMP-13),collagen-Ⅱ,aggrecan,interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),and IL-6 were measured by enzyme-linked immunosorbent *** joint space was assessed by a Perlove X-ray *** was examined by hematoxylin-eosin and Safranin O *** mRNA and protein expression levels of Notch1,MMP-13,collagen-Ⅱ,and aggrecan were measured by quantitative reverse transcription-polymerase chain reaction and Western blotting,***:SMAO plus Chinese medical massage significantly decreased the levels of MMP-13,IL-1β,TNF-α,and IL-6,and increased serum collagen-Ⅱ and aggrecan *** injury of the knee joint was improved by SMAO *** and protein expression of Notch1 and MMP-13 was remarkably downregulated,but collagen-Ⅱ and aggrecan levels were significantly upregulated in cartilage ***:SMAO combined with Chinese medical massage effectively relieves OA symptoms,which may involve inhibiting inflammation through the Notch1/MMP-13 signaling pathway.

关键词： osteoarthritis massage Salvia miltiorrhiza asarum ointments receptor Notch1 matrix metalloproteinase 13

Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis

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Journal of Traditional Chinese Medical Sciences 2017年第3期4卷 261-271页

作者： Min Liu Wenting Ji Liye Pan Qingguo Wang Gang Zhou Beijing University of Chinese Medicine Beijing 100029China

Objective:Ephedra asarum aconite decoction is used in the clinical treatment of allergic *** investigated the effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis and in activated T cells in ***:Animal models of simple and compound kidney yang deficiency types of allergic rhinitis were treated with ephedra asarum aconite decoction to observe the efficacy of this traditional Chinese medicine formula on allergic symptoms,serum cytokines,and tissue RNA *** also cultured and activated T cells from the *** treatment with ephedra asarum aconite decoction,we tested the proliferation and differentiation of T ***:Ephedra asarum aconite decoction relieved allergy symptoms in both types of animal models,and was more effective in the compound kidney yang deficiency model In addition to its anti-allergic efficacy,ephedra asarum aconite decoction significantly improved the health status of animals in the compound kidney yang deficiency groups,significantly made their bodyweight rising up,and significantly increased the T-bet mRNA/GATA-3 mRNA ***,ephedra asarum aconite decoction promoted the proliferation of activated T cells and inhibited the differentiation to Th2 cells in ***:Ephedra asarum aconite decoction regulates the balance of Th1/Th2 to ameliorate allergic conditions.

关键词： Ephedra asarum aconite decoction Th1/Th2 Allergic rhinitis Guinea pigs

湖南细辛属(asarum L.)植物资源及利用研究——湘细辛的植物研究

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湖南中医杂志 1986年第2期 30-33页

作者：周天达杨广民湖南中医学院中药系湖南中医学院中药系

细辛为常用中药,《神农本草经》列为上品,是历代医家用于治疗风湿痹痛等病的重要中药。近代药理实验研究证明细辛具有降压、强心和镇静麻醉作用,对冠心病、心绞痛等疾病有显著疗效,是宽胸丸的主要成分之一。中医习用的辽细辛(asarum he... 详细信息

细辛为常用中药,《神农本草经》列为上品,是历代医家用于治疗风湿痹痛等病的重要中药。近代药理实验研究证明细辛具有降压、强心和镇静麻醉作用,对冠心病、心绞痛等疾病有显著疗效,是宽胸丸的主要成分之一。中医习用的辽细辛(asarum heterotropoides ***(Maxim.)kitag)及华细辛(*** Miq.)均不能满足临床需要。据报道,我国有细辛属植物40种,各地均作细辛或土细辛入药。湖南商品药材“湘细辛”,不仅供本省使用,还销售省外,但其原植物

关键词： asarum 细辛属土细辛植物资源辽细辛华细辛宽胸丸商品药材药理实验研究植物研究

Beta-asarone inhibits synaptic inputs to airway preganglionic parasympathetic motoneurons

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Beta-asarone inhibits synaptic inputs to airway preganglioni...

毛细辛挥发油的中枢抑制、解热镇痛和担炎作用(摘要)

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Dong-Ying QIU~(1,2),Li-Li HOU~(1,2),Yong-Hua CHEN~1,Xu-Jiao ZHOU~1,Lei ZHU~,Ji-Jiang WANG~(1,*) 1 The State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences,Fudan University Shanghai Medical College,138 Yi-Xue-Yuan Road,Shanghai 200032,China 2 Fudan University Zhongshan Hospital,180 Fenglin Road,Shanghai 200032,China

＜正＞Therapeutic application of asarum,a herbal medicine that has been used for centuries,reportedly causes acute respiratory *** responsible constituents,the sites of action,and the mechanisms involved in this side effect are *** investigated the effects ofβ-asarone,a volatile constituent of asarum,on neurotransmission in the medullary respiratory neuronal network using extracellular recording of the rhythmic hypoglossal activity and voltage clamp recordings of the postsynaptic activity of the airway preganglionic parasympathetic motoneurons （APPMs）in vitro,β-asarone caused progressive decreases in the duration and area of the hypoglossal bursts in a concentration-dependent *** frequency and amplitude of the bursts were initially unaltered or temporarily increased,but were then inhibited progressively after prolonged *** with the inhibition of the hypoglossal bursts,the tonic and the phasic excitatory and inhibitory postsynaptic currents in the APPMs were attenuated. These data suggest that the asarum-caused acute respiratory disturbance involvesβ-asarone-induced inhibition of neurotransmission in the medullary respiratory neuronal network.

关键词： respiration asarum neurotransmission

来源： cnki会议评论

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宁夏医科大学学报 1991年第4期27卷 64-65页

作者：谢伟陆满文宁夏医学院药理学教研室

本文报告了宁夏六盘山区所产毛细辛(Asarura himalaicum Hook *** Tho-ms.)挥发油(毛油)的中枢抑制、解热镇痛和抗炎作用并与中医传统使用的辽细辛(asarum heterotropoides ***(Maxim.)Kitag.)挥发油(辽油)进行比较。一、中枢抑制作用... 详细信息

本文报告了宁夏六盘山区所产毛细辛(Asarura himalaicum Hook *** Tho-ms.)挥发油(毛油)的中枢抑制、解热镇痛和抗炎作用并与中医传统使用的辽细辛(asarum heterotropoides ***(Maxim.)Kitag.)挥发油(辽油)进行比较。一、中枢抑制作用毛细辛油0.06ml/

关键词：细辛挥发油解热镇痛中枢抑制辽细辛 asarum 宁夏六盘山角叉菜胶大鼠足肿胀自主活动巴豆油

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利用老参地栽培细辛技术

人参研究 1990年第3期2卷 39-40,11页

作者：张铭远王素珍尤金兰李清林杨永良吉林人参研究所通化市东昌区参场

细辛 asarum sieboldi *** Maxim.[马兜铃科]是我省的地道中药材之一.在国内外市场上都享有盛名.细辛主要含挥发油,油中主要成份为甲基丁香酚、黄樟醚、优香芹酮、细辛酮。

关键词：细辛素马兜铃科 asarum 甲基丁香酚黄樟香芹酮风湿关节痛根茎繁殖分批采收生长年限

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辽细辛栽培技术

林业科技通讯 2016年第9期 79-80页

作者：郑颖辽宁省林业科学研究院沈阳110032

主要介绍辽细辛(asarum heterotropoides)的种子习性、植株生长发育特性、选地整地、播种育苗、林下移栽、田间管理等方面的栽培技术。

关键词：辽细辛 asarum heterotropoides 中草药栽培技术

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辽细辛与伪品盆草细辛的鉴别

山东中医杂志 1987年第5期 38-38页

作者：孙义才姚素霞山东省药品检验所山东省立医院进修生

细辛为马兜铃科植物北细辛(asarum heter-otro poides ***(Maxi-m.)Kitag.)汉城细辛(*** *** Nakai)或华细辛(***-i Miq.)的干燥全草。有祛风散寒、通窍止痛、温肺化饮的功能,用于风寒感冒、头痛、牙痛、鼻渊、风湿痹痛、痰饮喘咳。近... 详细信息

细辛为马兜铃科植物北细辛(asarum heter-otro poides ***(Maxi-m.)Kitag.)汉城细辛(*** *** Nakai)或华细辛(***-i Miq.)的干燥全草。有祛风散寒、通窍止痛、温肺化饮的功能,用于风寒感冒、头痛、牙痛、鼻渊、风湿痹痛、痰饮喘咳。近年来在我省部分地区发现由外省调进一批盆草细辛(*** Thoms),经查该品药典未收载,属于地方习用药材,我省不使用。为了严把药材质量关,确保甩药安全有效,对盆草细辛从性状、镜检、薄层层析与辽细辛(北细辛)做了对比实验,现报告如下。

关键词：辽细辛马兜铃科植物习用药材温肺化饮通窍止痛 asarum 药材质量风寒感冒薄层层析伪品