Beta-asarone inhibits synaptic inputs to airway preganglionic parasympathetic motoneurons
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：respiration Asarum neurotransmission
摘 要：正Therapeutic application of Asarum,a herbal medicine that has been used for centuries,reportedly causes acute respiratory *** responsible constituents,the sites of action,and the mechanisms involved in this side effect are *** investigated the effects ofβ-asarone,a volatile constituent of Asarum,on neurotransmission in the medullary respiratory neuronal network using extracellular recording of the rhythmic hypoglossal activity and voltage clamp recordings of the postsynaptic activity of the airway preganglionic parasympathetic motoneurons （APPMs）in vitro,β-asarone caused progressive decreases in the duration and area of the hypoglossal bursts in a concentration-dependent *** frequency and amplitude of the bursts were initially unaltered or temporarily increased,but were then inhibited progressively after prolonged *** with the inhibition of the hypoglossal bursts,the tonic and the phasic excitatory and inhibitory postsynaptic currents in the APPMs were attenuated. These data suggest that the Asarum-caused acute respiratory disturbance involvesβ-asarone-induced inhibition of neurotransmission in the medullary respiratory neuronal network.