Effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis

作     者：Min Liu Wenting Ji Liye Pan Qingguo Wang Gang Zhou 

作者机构：Beijing University of Chinese MedicineBeijing 100029China 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2017年第4卷第3期

页      面：261-271页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This study is supported by National Natural Science Foundation of China(8120272) Scientific Research in Beijing University of Chinese Medicine(2016-JYB-JSMS-001,2016-JYB-XS011) International Natural Science Foundation 

主　　题：Ephedra asarum aconite decoction Th1/Th2 Allergic rhinitis Guinea pigs 

摘      要：Objective:Ephedra asarum aconite decoction is used in the clinical treatment of allergic *** investigated the effects of ephedra asarum aconite decoction on Th1/Th2 balance in two animal models of allergic rhinitis and in activated T cells in ***:Animal models of simple and compound kidney yang deficiency types of allergic rhinitis were treated with ephedra asarum aconite decoction to observe the efficacy of this traditional Chinese medicine formula on allergic symptoms,serum cytokines,and tissue RNA *** also cultured and activated T cells from the *** treatment with ephedra asarum aconite decoction,we tested the proliferation and differentiation of T ***:Ephedra asarum aconite decoction relieved allergy symptoms in both types of animal models,and was more effective in the compound kidney yang deficiency model In addition to its anti-allergic efficacy,ephedra asarum aconite decoction significantly improved the health status of animals in the compound kidney yang deficiency groups,significantly made their bodyweight rising up,and significantly increased the T-bet mRNA/GATA-3 mRNA ***,ephedra asarum aconite decoction promoted the proliferation of activated T cells and inhibited the differentiation to Th2 cells in ***:Ephedra asarum aconite decoction regulates the balance of Th1/Th2 to ameliorate allergic conditions.