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antifungal therapy for treatment of cryptococcal meningitis

Chinese Medical Journal 2000年第2期000卷 82-84页

作者：姚志荣廖万清温海

Objective To compare the curative effects of three different antifungal regimens in the treatment of cryptococcal meningitis Methods Twenty two patients were divided into 3 groups: Group Ⅰ was given intravenous amphotericin B alone or combination with flucytosine therapy Group Ⅱ received intravenous fluconazole alone or combination with flucytosine The treatment of Group Ⅲ was divided into two steps, where the patients received intrathecal amphotericin B plus intravenous amphotericin B with or without intravenous fluconazole until the mycological culture of cerebrospinal fluid (CSF) turned negative, followed by oral fluconazole or itraconazole as maintenance therapy until direct microscopic examination of CSF showed negative once a week for three consecutive weeks Results Of the twenty two patients, 17 (77 3%) were cured, 2 (9 1%) improved, 3 (13 6%) died, and one (4 5%) relapsed Of the 8 patients in Group Ⅰ, 5 were cured, 2 improved, one died and one relapsed; Of the 4 patients in Group Ⅱ, 2 were cured, and 2 died; All the 10 patients in Group Ⅲ were cured without any recurrence Conclusion The two step therapeutic regimen may be suited to the treatment of cryptococcal meningitis

关键词： cryptococcal meningitis · antifungal therapy

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Phospholipid/protein co-mediated assembly of Cu_(2)O nanoparticles for specific inhibition of growth and biofilm formation of pathogenic fungi

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Science China Materials 2021年第3期64卷 759-768页

作者： Liping Peng Henan Wei Lei Tian Jiachun Xu Mingchun Li Qilin Yu Key Laboratory of Molecular Microbiology and Technology Ministry of EducationDepartment of MicrobiologyCollege of Life SciencesNankai UniversityTianjin300071China

As the increasing number of the individuals suffering from AIDs,chemotherapy,and radiotherapy,pathogenic fungi,which may rapidly grow and invade the host tissues in these immune-compromised patients,is becoming great threat to human *** this study,we constructed a novel fungal pathogen-responsive assembly of cuprous oxide(Cu_(2)O)nanoparticles(NPs)for specific targeting and inhibiting growth and biofilm formation of the representative fungal pathogen,Candida albicans(***).This assembly was formed by coating the initial Cu_(2)O NPs with both phosphatidylethanolamine(PE)and bovine serum albumin(BSA),followed by hydrophobic/electrostatic interaction-driven formation of the Cu_(2)O-PE-BSA *** formed microaggregates could be induced for disassembly by the fungal pathogen ***,leading to close binding of the NPs to the cell wall of the *** confocal microscopy and viability assays showed that the assembly strongly inhibited growth and biofilm formation of the pathogen,but had extreme low toxicity to mammalian *** vivo mouse wound model further revealed that the assembly had high capacity of healing the fungus-infected wounds and reduced the fungal burden of the wound *** study sheds a novel light on facile development of pathogen-responsive nano-assemblies for efficient and safe antifungal therapy.

关键词： Cu_(2)O nanoparticle assembly fungal pathogen biofilm antifungal therapy

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A Bronchopulmonary Onset of Candidemia Revealing a Granulomatosis with Polyangiitis

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Case Reports in Clinical Medicine 2024年第5期13卷 147-154页

作者： Chaïmaâ Zeroual Mina Moudatir Khadija Echchilali Leila Barakat Hassan El Kabli Department of Internal Medicine Ibn Rochd University Hospital Center Casablanca Morocco

Candidemia is defined as being a yeast infection confirmed by the presence of at least one positive Candida blood culture. It is a life threatening infection causing high mortality. The clinical signs are generally compatible with the causative agent (whether there is a deep venous catheter or not). On the other hand and according to the 2012 Revised Chapel Hill Classification, granulomatosis with polyangiitis GPA is classified as a vasculitis associated with antineutrophil cytoplasmic antibodies ANCA. It is a systemic disease characterized by the anatomopathological aspect of granuloma. We report the case of a patient who presented an atypical and a very rare revealing mode of GPA which was a bronchopulmonary candidiasis complicated by candidemia. Despite its controversy, the combination in the acute phase of antifungal treatment based on intravenous voriconazole and glucocorticoid therapy has made it possible to control candidemia and calm vasculitis.

关键词： Candidemia C. glabrata Pulmonary Candidiasis Vasculitis Immunodepression Granulomatosis with Polyangiitis Cavitary Lesions antifungal therapy Immunosuppressants

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Evidence for a ‘preinvasive’ variant of fungal sinusitis: Tissue invasion without angioinvasion

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第1期3卷 -页

作者： Hassan Paknezhad Nicole A.Borchard Greg W.Charville Noel F.Ayoub Garret W.Choby Andrew Thamboo Jayakar V.Nayak Division of Rhinology Department of Otolaryngology-Head and Neck SurgeryStanford University School of MedicineUSA

Clinical experience has suggested the existence of an intermediate form of fungal sinusitis between the categories of non-invasive fungal sinusitis (non-IFS) and invasive fungal sinusitis (IFS).This fungal sinusitis variant demonstrates unhealthy mucosa by endoscopy with fungal invasion,but lacks angioinvasion microscopically,representing what clinically behaves as a ‘pre-invasive’ subtype of fungal *** non-IFS disease,patients with preinvasive fungal sinusitis were still felt to require anti-fungal medications due to histologic presence of invasive *** sharing some clinical features of IFS,these ‘intermediate’ patients were successfully spared extended and repeated surgical debridements given the microscopic findings,and have been successfully treated with shorter courses of antifungal *** select patients have had favorable outcomes when managed in a judicious and semi-aggressive manner,in an undefined zone between the treatments for routine fungal ball and aggressive IFS.

关键词： Fungal sinusitis Invasive fungal sinusitis IFS Chronic rhinosinusitis Fungal ball Visual loss Immunocompromised Immunosuppressed antifungal therapy

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A Case of Invasive Pulmonary Aspergillosis Resulted from the Treatment of Chronic Eczema

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Journal of Geriatric Medicine 2022年第2期4卷 1-3页

作者： Mimi Zhou Jianbo Hong Yue Chen No.1 Department of Geriatrics Hangzhou Wenzhong HospitalHangzhou310000China

This was an advanced male(87-year-old)with refractory chronic eczema for over 40 years,based on his allergic constitution,accompanied with chronic kidney disease due to primary hypertension(CKD,phase 3).It was so difficult to tolerate the severe itching that the glucocorticoids(GC)had to be applied to it,but some new-onset respiratory symptoms,such as cough,dyspnea after exertion etc.,occurred to this *** classical IPA images were found on his pulmonary CT scanning,which were further comfirmed by the positive findings of GM-test,and then a final diagnosis of IPA was accordingly ***,a persistent fever emerged after starting an antifungal therapy to the patient,and his IL-2 level was detected to be *** a response to allergic fever,GC was carefully given intravenously again to treat it,and it turned out to be totally improved since then;suggesting that systemic thinking(integrated with the other clinical evidences)is essential to diagnose IPA,and GC can also be used to improve its symptoms with the existence of antifungal therapy.

关键词： Chronic eczema Glucocorticoids Invasive pulmonary aspergillosis Allergic fever antifungal therapy

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