Phospholipid/protein co-mediated assembly of Cu_(2)O nanoparticles for specific inhibition of growth and biofilm formation of pathogenic fungi

作     者：Liping Peng Henan Wei Lei Tian Jiachun Xu Mingchun Li Qilin Yu 彭丽萍;卫贺南;田雷;许佳春;李明春;喻其林

作者机构：Key Laboratory of Molecular Microbiology and TechnologyMinistry of EducationDepartment of MicrobiologyCollege of Life SciencesNankai UniversityTianjin300071China 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2021年第64卷第3期

页      面：759-768页

核心收录：

学科分类：081702[工学-化学工艺] 07[理学] 070205[理学-凝聚态物理] 08[工学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 100103[医学-病原生物学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(31870139 and 81873961) the Natural Science Foundation of Tianjin(19JCZDJC33800) the National Training Program of Innovation and Entrepreneurship for Undergraduates(201810055105) the Fundamental Research for the Central Universities 

主　　题：Cu_(2)O nanoparticle assembly fungal pathogen biofilm antifungal therapy 

摘      要：As the increasing number of the individuals suffering from AIDs,chemotherapy,and radiotherapy,pathogenic fungi,which may rapidly grow and invade the host tissues in these immune-compromised patients,is becoming great threat to human *** this study,we constructed a novel fungal pathogen-responsive assembly of cuprous oxide(Cu_(2)O)nanoparticles(NPs)for specific targeting and inhibiting growth and biofilm formation of the representative fungal pathogen,Candida albicans(***).This assembly was formed by coating the initial Cu_(2)O NPs with both phosphatidylethanolamine(PE)and bovine serum albumin(BSA),followed by hydrophobic/electrostatic interaction-driven formation of the Cu_(2)O-PE-BSA *** formed microaggregates could be induced for disassembly by the fungal pathogen ***,leading to close binding of the NPs to the cell wall of the *** confocal microscopy and viability assays showed that the assembly strongly inhibited growth and biofilm formation of the pathogen,but had extreme low toxicity to mammalian *** vivo mouse wound model further revealed that the assembly had high capacity of healing the fungus-infected wounds and reduced the fungal burden of the wound *** study sheds a novel light on facile development of pathogen-responsive nano-assemblies for efficient and safe antifungal therapy.