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anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice(Mus musculus)

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 155-158页

作者： Faizal Rajeeb Mangudadatu Hussin Rodel Jonathan Santos Vitor Ⅱ Julie Ann Oraa Joaquin Melody Mendoza Clerigo Anamy Ma.Caterial Paano Biology Department College of Science De La Salle University Chemistry Department College of Science De La Salle University

Objective: To examine the anti-hyperglycemic effects of aqueous Lenzites betulina(L. betulina) extracts on normoglycemic glucose-loaded ***: Different doses of aqueous extract from L. betulina were administered to 45 ICR mice(Mus musculus) to determine whether there was an effect of L. betulina extracts on the blood glucose level of the ICR mice. Aqueous extracts of L. betulina were orally gavaged to mice using oral glucose tolerance test. A total of five groups were used to determine the effect of the fungi on blood glucose of the mice. Group A(positive control)was given 16.7 mg/kg glimepiride; Group B(negative control) was given distilled water;Group C(low dosage) was given 200 mg/kg aqueous extract; Group D(mid dosage) was given 400 mg/kg aqueous extract and Group E(high dosage) was given 800 mg/kg aqueous extract. Baseline blood glucose value was firstly acquired before induction of hyperglycemia through D-glucose, after which another check on blood glucose was made after 0.5 h. Immediately, after the acquisition of hyperglycemic blood glucose level, the individual administration of treatments were done. After that, three blood collections were done spanning 3 h with 1 h ***: The low dose(200 mg/kg) and the mid dose(400 mg/kg) of L. betulina extracts were significantly different(P 0.05) from its corresponding baseline value, acting faster than the positive control(glimepiride), which only became significantly different(P < 0.05) at the 2nd ***: Aqueous L. betulina extract is able to produce hypoglycemic effects on the mice with all doses, which are able to normalize blood glucose levels at varying times.

关键词： anti-hyperglycemic Glucose Lenzites betulina ICR mice Oral Glucose tolerance test

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anti-hyperglycemic property of Hericium erinaceus --A mini review

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1036-1040页

作者： Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Innovation Center for Holistic Health Nutraceuticalsand CosmeceuticalsFaculty of PharmacyChiang Mai UniversityThailand

Hericium erinaceus(H. erinaceus) is one of the widely used edible mushrooms around the world, primarily in Asian countries. H. erinaceus is used in traditional medicines, and mushroom based foods. The fruiting body and mycelia of H. erinaceus are extracted using the solvents, and several bioactive compounds were identified. Several studies have reported that those bioactive compounds exhibit many health benefits such as hemagglutinating, antimicrobial, immunomodulatory, antitumor, antioxidant, and anti-aging activities, etc. This manuscript consciously updated the information about the composition of H. erinaceus, H. erinaceus based foods, and anti-hyperglycemic property of H. erinaceus.

关键词： anti-hyperglycemic Diabetes Fermented Hericium erinaceus juice Hericium erinaceus Polysaccharides

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Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy

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Acta Pharmaceutica Sinica B 2018年第6期8卷 919-932页

作者： Yanbo Tang Xiaolin Zhang Zheng Chen Wenwen Yin Guanglei Nan Jinying Tian Fei Ye Zhiyan Xiao Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Based on a non-competitive and selective PTP1 B inhibitor reported by us previously, thirtynine benzamido derivatives were designed and synthesized as novel PTP1 B inhibitors. Among them,twelve compounds exhibited IC_(50) values at micromolar level against human recombinant PTP1 B, and most of them exhibited significant selectivity to PTP1 B over TC-PTP and CD45. Further evaluation of the most potent compound 27 on high-fat diet(HFD)-induced insulin-resistant(IR) obese mice indicated that27 could modulate glucose metabolism and ameliorate dyslipidemia simultaneously.& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： PTP1B inhibitors Benzamido derivatives Structureactivity relationship anti-hyperglycemic Lipid-lowering

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Evaluation of anti-hyperglycemic and anti-Hyperlipidemic Activities of Water Kefir as Probiotic on Streptozotocin-Induced Diabetic Wistar Rats

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Journal of Diabetes Mellitus 2014年第2期4卷 85-95页

作者： Muneer Alsayadi Yaser Al Jawfi Meriem Belarbi Zoubida Soualem-Mami Hafida Merzouk Daoudi Chaban Sari Fatima Sabri Meriem Ghalim Department of Food Science and Technology Faculty of agricultureIbb UniversityIbbYemen Laboratory of Natural Products Department of BiologyFaculty of Natural and Life SciencesEarth andUniverseUniversity of Abou-Bekr BelkaidTlemcenAlgeria Department of Food Safety Station of Agriculture ResearchesSana’aYemen Laboratory of Physiology Physiopathology and Biochemistry of NutritionDepartment of BiologyFaculty of Natural and Life SciencesEarth and UniverseUniversity of Abou-Bekr BelkaidTlemcenAlgeria

Diabetes mellitus is a predominant chronic disease which causes mortality of millions of people yearly. Its prevalence is on the rise worldwide. Water kefir is fermented food produced by a matrix of polysaccharides containing bacteria and yeasts, with therapeutic properties. Our study aimed to evaluate anti-hyperglycemic and anti-hyperlipidemic activities of water kefir on streptozotocin-induced diabetic Wistar rats. Adult Wistar rats were made diabetic by intraperitoneal injection of streptozotocin, and were given or not kefir in drinking water for 5 weeks. Body weight, glucose and lipid levels were measured. The results demonstrated evident improvement in body weight, glucose, and lipid profiles of treated rats comparing with diabetic or control rats. Water kefir is found to be less cost hypoglycemic and hypolipidimic treatment and less time consuming. Water kefir can potentially be useful food for diabetes to control glucose and lipid levels.

关键词： Component Formatting Style Styling anti-hyperglycemic anti-Hyperlipidaemic Water Kefir Diabetes Wistar Rat

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Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats

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Food Science and Human Wellness 2020年第4期9卷 346-354页

作者： Baskaran Krishnan Abirami Ramu Ganesan Ravindran Balasubramani Dinh Duc Nguyen Soon Woong Chang Shaoyun Wang Jianbo Xiao Balamuralikrishnan Balasubramanian Department of Biochemistry Sree Narayana Guru CollegeCoimbatore641105Tamil NaduIndia Department of Food Science and Home Economics School of Applied SciencesCollege of EngineeringScience and TechnologyFiji National UniversityFiji Islands Department of Environmental Energy and Engineering Kyonggi UniversityYoungtong-GuSuwonGyeonggi-Do16227South Korea College of Biological Science and Technology Fuzhou UniversityFuzhou 350108China International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013China Department of Food Science and Biotechnology College of Life SciencesSejong UniversitySeoul05006South Korea

The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar *** rats were categorized as control,diabetic control supplemented with 0,20 mg/kg chrysoeriol and 600μg/kg BW of glibenclamide for 45-day trial *** results indicated that the inclusion of chrysoeriol(20 mg/kg)showed a significant reduction in plasma glucose,hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin ***,downregulated enzymes including glucose 6-phosphatase,fructose 1,6-bisphosphatase,and glycogen phosphorylase as well upregulated enzymes such as hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,and hepatic glycogen *** was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase,towards normal levels upon treatment with *** histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated *** addition,the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide,as a standard ***,chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes.

关键词： Cardiospermum halicacabum Chrysoeriol anti-hyperglycemic Carbohydrate metabolizing enzymes

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Bioactivity of methanolic extract of Brassica juncea in animal model of diabetes mellitus

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Chinese Herbal Medicines 2019年第4期11卷 434-437页

作者： Anuj Kumar Akhilesh Kumar Rana Amit Singh Alok Singh Department of Pharmacology Institute of Medical SciencesBanaras Hindu UniversityVaranasiUttar Pradesh 221005India Department of Pharmacology All India Institute of Medical SciencesRaipurChhattisgarh 492099India

Objective:To study the bioactivity of methanolic extract of Brassica juncea on animal model of diabetes mellitus along with its effect on diabetic and metabolic ***:Diabetes mellitus was induced in rats by injecting streptozotocin(60 mg/kg)*** glucose was measured on day 3 by GOD-POD method to confirm the diabetes *** having fasting blood glucose>250 mg/d L were further selected for study and they were divided into four groups,control,control+streptozotocin,streptozotocin+metformin(75 mg/kg)and streptozotocin+extract of ***(450 mg/kg).Each group consisted of six rats of either *** and experimental extract were administered for 21 ***,cholesterol level were measured on day 21 by commercially available *** glucose was measured on days 7 and ***-oxidant potential was assessed by estimating extent of lipid peroxidation(LPO)by malondialdehyde(MDA),nitric oxide(NO),superoxide dismutase(SOD)and glutathione(GSH)in liver,kidney,pancreas,muscle tissues on day *** and paired student’s t-test was applied for statistical ***:The extract of *** showed significant decrease in blood glucose level on day *** treatment group showed significant difference in oxidative stress by increasing SOD and GSH and decreasing LPO and NO activity on day *** treatment did not show statistically significant difference of cholesterol,and triglycerides level on day ***:The study showed anti-hyperglycemic and anti-oxidative properties of methanolic extract of ***.

关键词： anti-hyperglycemic anti-oxidant Brassica juncea(L.)Czern.et Coss

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Effects of Bofutsushosan and Gardeniae Fructus on Diabetic Serum Parameters in Streptozotocin-Induced Diabetic Mice

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Chinese Medicine 2011年第4期2卷 130-137页

作者： Qing Yu Mai Yasuda Tatsuo Takahashi Masaaki Nomura Nobuyoshi Hagino Shinjiro Kobayashi 不详

Streptozotocin (STZ)-induced diabetic mice increased levels of serum glucose, triglyceride and cholesterol, and decreased level of serum insulin. Effects of Bofutsushosan (BOF: Pulvis ledebouriellae compositae: 防風通聖散) and its composed crude drug, gardeniae fructus (GF: 山梔子) were investigated on levels of these diabetic parameters (serum glucose, insulin, triglyceride and cholesterol) in STZ-diabetic mice. BOF and GF were extracted in 10 volumes of distilled water with an automatic extractor “Torobi”. STZ-induced diabetic mice with serum glucose level of over 600 mg/dl at 3 - 4 weeks after intravenous injection of 150 mg/kg STZ were used for experiments. BOF extract, GF extract, geniposide (a main constituent of GF), and glibenclamide were administered intraperitoneally into 3-hour-fasted STZ-diabetic mice. At 6 hours after administration, BOF extract (100 - 300 mg/kg) decreased high levels of serum glucose, triglyceride and cholesterol, and also increased low level of serum insulin in STZ-diabetic mice in a dose-dependent manner, respectively. anti-diabetic drug glibenclamide (0.3 - 1 mg/kg) as positive control significantly decreased serum glucose and cholesterol levels, and increased serum insulin level in the diabetic mice. GF extract (30 - 300 mg/kg) decreased serum glucose, triglyceride and cholesterol levels but did not affect serum insulin level in the diabetic mice. Geniposide (10 - 100 mg/kg), decreased serum glucose level but did not affect serum insulin and triglyceride levels in the diabetic mice. These results demonstrated that intraperitoneally administrated BOF extract improved abnormal levels of serum glucose, insulin, triglyceride and cholesterol in the STZ-diabetic mice as being similar to glibenclamide. GF extract has an important role in a part of improving actions of BOF in the diabetic mice. The action of GF extract on serum glucose was parallel with the action of geniposide in the diabetic mice, supporting roles of geniposide in anti-hyperglyc

关键词： Bofutsushosan (Pulvis Ledebouriellae Compositae: 防風通聖散) Gardeniae Fructus (山梔子) Geniposide Streptozotocin-Induced Diabetic Mice anti-hyperglycemic Action An-ti-Hyperlipidemic Action

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