Bioactivity of methanolic extract of Brassica juncea in animal model of diabetes mellitus

作     者：Anuj Kumar Akhilesh Kumar Rana Amit Singh Alok Singh 

作者机构：Department of PharmacologyInstitute of Medical SciencesBanaras Hindu UniversityVaranasiUttar Pradesh 221005India Department of PharmacologyAll India Institute of Medical SciencesRaipurChhattisgarh 492099India 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2019年第11卷第4期

页      面：434-437页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Banaras Hindu University(BHU)for providing grant to carry out study 

主　　题：anti-hyperglycemic anti-oxidant Brassica juncea(L.)Czern.et Coss 

摘      要：Objective:To study the bioactivity of methanolic extract of Brassica juncea on animal model of diabetes mellitus along with its effect on diabetic and metabolic ***:Diabetes mellitus was induced in rats by injecting streptozotocin(60 mg/kg)*** glucose was measured on day 3 by GOD-POD method to confirm the diabetes *** having fasting blood glucose250 mg/d L were further selected for study and they were divided into four groups,control,control+streptozotocin,streptozotocin+metformin(75 mg/kg)and streptozotocin+extract of ***(450 mg/kg).Each group consisted of six rats of either *** and experimental extract were administered for 21 ***,cholesterol level were measured on day 21 by commercially available *** glucose was measured on days 7 and ***-oxidant potential was assessed by estimating extent of lipid peroxidation(LPO)by malondialdehyde(MDA),nitric oxide(NO),superoxide dismutase(SOD)and glutathione(GSH)in liver,kidney,pancreas,muscle tissues on day *** and paired student’s t-test was applied for statistical ***:The extract of *** showed significant decrease in blood glucose level on day *** treatment group showed significant difference in oxidative stress by increasing SOD and GSH and decreasing LPO and NO activity on day *** treatment did not show statistically significant difference of cholesterol,and triglycerides level on day ***:The study showed anti-hyperglycemic and anti-oxidative properties of methanolic extract of ***.