Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats

作     者：Baskaran Krishnan Abirami Ramu Ganesan Ravindran Balasubramani Dinh Duc Nguyen Soon Woong Chang Shaoyun Wang Jianbo Xiao Balamuralikrishnan Balasubramanian Baskaran Krishnan;Abirami Ramu Ganesan;Ravindran Balasubramani;Dinh Duc Nguyen;Soon Woong Chang;Shaoyun Wang;Jianbo Xiao;Balamuralikrishnan Balasubramanian

作者机构：Department of BiochemistrySree Narayana Guru CollegeCoimbatore641105Tamil NaduIndia Department of Food Science and Home EconomicsSchool of Applied SciencesCollege of EngineeringScience and TechnologyFiji National UniversityFiji Islands Department of Environmental Energy and EngineeringKyonggi UniversityYoungtong-GuSuwonGyeonggi-Do16227South Korea College of Biological Science and TechnologyFuzhou UniversityFuzhou 350108China International Research Center for Food Nutrition and SafetyJiangsu UniversityZhenjiang 212013China Department of Food Science and BiotechnologyCollege of Life SciencesSejong UniversitySeoul05006South Korea 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2020年第9卷第4期

页      面：346-354页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：Indian Council of Medical Research, ICMR, (59/4/2008/BMS/TRM) Sejong University 

主　　题：Cardiospermum halicacabum Chrysoeriol Anti-hyperglycemic Carbohydrate metabolizing enzymes 

摘      要：The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar *** rats were categorized as control,diabetic control supplemented with 0,20 mg/kg chrysoeriol and 600μg/kg BW of glibenclamide for 45-day trial *** results indicated that the inclusion of chrysoeriol(20 mg/kg)showed a significant reduction in plasma glucose,hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin ***,downregulated enzymes including glucose 6-phosphatase,fructose 1,6-bisphosphatase,and glycogen phosphorylase as well upregulated enzymes such as hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,and hepatic glycogen *** was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase,towards normal levels upon treatment with *** histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated *** addition,the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide,as a standard ***,chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes.