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Early identification of acute hypoxia based on brain NADH fluores cence and cerebral blood flow

Journal of Innovative Optical Health Sciences 2014年第2期7卷 153-161页

作者： Hua Shi Nannan Sun Avraham Mayevsky Zhihong Zhang Qingning Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Scienceand Technology Wuhan 430074 P.R.China MoE Key Laboratory for Biomedical Photonics Department of Biomedical Engineering Huazhong University of Science and Technology(HUST)Wuhan 430074P.R.China

hypoxia is closely related to many diseases and often leads to *** detection andidentification of the hypoxia causes may help to promptly determine the right rescue plan andreduce the *** proposed a new multiparametric monitoring method employingmitochondrial reduced nicotinamide adenine dinucleotide(NA DH)fluorescence,regional reflectance,regional cerebral blood flow(CBF),electrocardiography(ECG),and respiration under sixkinds of acute hypoxia in four categories to investigate a correlation bet ween the parametervariances and the hypoxia *** variation patterns of the paramet ers were discussed,andthe combination of NADH and CBF may contribute to the identification of the causes of hypoxia.

关键词： Nicotinamide adenine dinucleotide fuorescence acute hypoxia carly detection cer-ebral blood flow.

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Metabolomic Study on Vitamins B_1, B_2, and PP Supplementation to Improve Serum Metabolic Profiles in Mice under acute hypoxia Based on ~1H NMR Analysis

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Biomedical and Environmental Sciences 2010年第4期23卷 312-318页

作者： JIN LIU JIAN-QUAN WU JI-JUN YANG JING-YU WEI WEI-NA GAO CHANG-JIANG GUO Institute of Hygiene and Environmental Medicine Tianjin 300050 China

Objective To explore metabolic changes after acute hypoxia and modulating effect of vitamins B1, B2, and PP supplementation in mice exposed to acute hypoxia. Methods Fifty male Kunming mice were randomly divided into 5 groups： normal, acute hypoxia, acute hypoxia with 2, 4 and 8 time- vitamins B1, B2, and PP supplementation . All mice were fed with corresponding diets for two weeks and then were exposed to a simulated altitude of 6 000 meters for 8 h, except for the normal group. Nuclear magnetic resonance analysis was used to identify the changes of serum metabolic profiles. Results There were significant changes in some serum metabolites under induced acute hypoxia, essentially relative increase in the concentrations of lactate, sugar and lipids and decrease in ethanol. The serum levels of choline, succinate, taurine, alanine, and glutamine also increased and phosphocholine decreased in the acute hypoxia group. After vitamins B1, B2, and PP supplementation, all these metabolic changes gradually recovered. Conclusion Significant changes in serum metabolic profile were observed by metabolomics in mice exposed to acute hypoxia, and vitamins B1, B2, and PP supplementation proved to be beneficial to improving some metabolic pathways. It is suggested that the dietary intakes of vitamins B1, B2, and PP should be increased under hypoxia condition.

关键词： Vitamins B1 B2 and PP acute hypoxia 1H NMR Mice

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Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress

Loss of cell adhesion molecule CHL1 improves homeostatic ada...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：黄欣 Weifang Rong Tong Zhao Liying Wu lingling Zhu Ming Fan 军事医学科学院基础医学研究所军事认知研究室

Objective CHL1 is a transmembrane cell adhesion molecule that is critical for brain development and in the maintenance of neural circuits in the *** studies revealed that CHL1 has diverse roles and is involved in the regulation of recovery after spinal cord ***1 expression was down-regulated in the cerebral cortex,hypothalamus and brain stem after induction of acute *** the current study we sought to address the role of CHL1 in regulating homeostasis responses to hypoxia using CHL1 knockout（CHL1-/-）*** We found that,compared with the wild type littermates,CHL1-/-mice showed a dramatically lower mortality rate and an augmented ventilatory response after they were subjected to acute *** staining revealed that CHL1 was expressed in the carotid body（CB）,the key oxygen sensor in rodents and CHL1 expression level in CB as assayed by western blot was decreased after hypoxic *** number of glomus cells and the expression of tyrosine hydroxylase（TH,a marker for glomus cells）in CB of CHL1-/-mice appeared to be increased compared with CHL1+/+*** addition,in the ex vivo carotid body preparation,hypoxia induced a significantly greater afferent nerve discharge in CHL1-/-mice compared with the CHL1+/+***,the arterial blood pressure and plasma catecholamine level of CHL1-/-mice were also significantly higher than those of CHL1+/+*** Our findings first demonstrate that CHL1 is a novel intrinsic factor that is involved in carotid body function and in the ventilatory response to acute hypoxia.

关键词： CHL1 acute hypoxia homeostatic adaptation survival

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Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress

Loss of cell adhesion molecule CHL1 improves homeostatic ada...

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中国神经科学学会第十届全国学术会议

作者： Xin HUANG Jia SUN Weifang RONG Tong ZHAO Li-ying WU Kuiwu WU Melitta SCHACHNER Zhi-Cheng XIAO Ling-ling ZHU Ming FAN Institute of Molecular and Clinical Medicine Kunming Medical College

Objective CHLl is a transmembrane cell adhesion molecule that is critical for brain development and in the maintenance of neural circuits in the *** studies revealed that CHLl has diverse roles and is involved in the regulation of recovery after spinal cord *** expression was down-regulated in the cerebral cortex,hypothalamus and brain stem after induction of acute *** the current study we sought to address the role of CHLl in regulating homeostasis responses to hypoxia using CHLl knockout(CHLl) *** We found that,compared with the wild type littermates,CHLl mice showed a dramatically lower mortality rate and an augmented ventilatory response after they were subjected to acute *** staining revealed that CHLl was expressed in the carotid body(CB),the key oxygen sensor in rodents and CHLl expression level in CB as assayed by western blot was decreased after hypoxic *** number of glomus cells and the expression of tyrosine hydroxylase(TH,a marker for glomus cells) in CB of CHLl mice appeared to be increased compared with *** addition,in the ex vivo carotid body preparation,hypoxia induced a significantly greater afferent nerve discharge in CHLl mice compared with the CHL1 ***,the arterial blood pressure and plasma catecholamine level of CHLl mice were also significantly higher than those of CHL1 *** Our findings first demonstrate that CHLl is a novel intrinsic factor that is involved in carotid body function and in the ventilatory response to acute hypoxia.

关键词： CHL1 acute hypoxia homeostatic adaptation survival

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