Early identification of acute hypoxia based on brain NADH fluores cence and cerebral blood flow

作     者：Hua Shi Nannan Sun Avraham Mayevsky Zhihong Zhang Qingning Luo 

作者机构：Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Scienceand Technology Wuhan 430074P.R.China MoE Key Laboratory for Biomedical Photonics Department of Biomedical Engineering Huazhong University of Science and Technology(HUST)Wuhan430074P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2014年第7卷第2期

页      面：153-161页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：supported bythe 111 Project of China(B07038) alsosupported by the Ph.D.Programs Foundation of the Mimnistry of Education of China(Grant_No.20110142130006) the Director Fund of Wuhan National Laboratory for Optoelectronics(WNLO,2009,Z.H.ZHANG). 

主　　题：Nicotinamide adenine dinucleotide fuorescence acute hypoxia carly detection cer-ebral blood flow. 

摘      要：Hypoxia is closely related to many diseases and often leads to death.Early detection andidentification of the hypoxia causes may help to promptly determine the right rescue plan andreduce the mortality.We proposed a new multiparametric monitoring method employingmitochondrial reduced nicotinamide adenine dinucleotide(NA DH)fluorescence,regional reflectance,regional cerebral blood flow(CBF),electrocardiography(ECG),and respiration under sixkinds of acute hypoxia in four categories to investigate a correlation bet ween the parametervariances and the hypoxia causes.The variation patterns of the paramet ers were discussed,andthe combination of NADH and CBF may contribute to the identification of the causes of hypoxia.