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Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction

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Bioactive Materials 2022年第10期7卷 334-345页

作者： Jingyi Wang Yiyu Peng Menglu Chen Xizhe Dai Lixia Lou Changjun Wang Zhaonan Bao Xianyan Yang Zhongru Gou Juan Ye Eye Center The Second Affiliated HospitalZhejiang University School of MedicineZhejiang Provincial Key Lab of OphthalmologyHangzhou310009PR China Department of Ophthalmology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou310051PR China Zhejiang-California International NanoSystems Institute Zhejiang UniversityHangzhou310029PR China

Eyeball loss due to severe ocular trauma,intraocular malignancy or infection often requires surgical treatment called orbital implant reconstruction to rehabilitate the orbital volume and restore the aesthetic ***,it remains a challenge to minimize the postoperative exposure and infection complications due to the inert nature of conventional orbital ***,we developed a novel Ca-Zn-silicate bioceramic implant with multi-functions to achieve the expected *** porous hardystonite(Ca2ZnSi2O7)scaffolds with triply periodic minimal surfaces(TPMS)-based pore architecture and graded pore size distribution from center to periphery(from 500 to 800μm or vice versa)were fabricated through the digital light processing(DLP)technique,and the scaffolds with homogeneous pores(500 or 800μm)were fabricated as *** graded porous scaffolds exhibited a controlled bio-dissolving behavior and intermediate mechanical strength in comparison with the homogeneous counterparts,although all of porous implants presented significant antibacterial potential against *** and ***,the pore size-increasing scaffolds indicated more substantial cell adhesion,cell viability and angiogenesis-related gene expression in ***,the gradually increasing pore feature exhibited a stronger blood vessel infiltrating potential in the dorsal muscle embedding model,and the spherical implants with such pore structure could achieve complete vascularization within 4 weeks in the eyeball enucleation rabbit ***,our results suggested that the novel antibacterial hardystonite bioceramic with graded pore design has excellent potential as a next-generation orbital implant,and the pore topological features offer an opportunity for the improvement of biological performances in orbital reconstruction.

关键词： Graded porous scaffolds Fibro-vascularization antibacterial Hardystonite Orbital implants

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LncRNA MIR144HG-derived miR-144 suppresses antibacterial signaling and facilitates bacteria escape in fish

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Water Biology and Security 2023年第1期2卷 72-85页

作者： Weiwei Zheng Junxia Cui Xing Lv Shiying Xin Tianjun Xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266200China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of EducationShanghai201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China

Growing number studies show that lncRNA is an important regulatory factor and plays an irreplaceable role in innate ***,most studies on lncRNA have focused on mammals and it is unknown in lower *** this study,we identify a new lncRNA,named MIR144HG,which can have a negative role in antibacterial immunity of Miichthys miiuy caused by Vibrio anguillarum and ***88,TAK1 and p65 are very important pathway genes in antibacterial innate immune responses,whether in mammals or lower ***,we found that miR-144–3p could target MyD88,TAK1 and p65,inhibit host antibacterial response and promote bacterial *** studies found that miR-144–3p can be derived by MIR144HG,and finally enhance the inhibitory effect of miR-144–3p on host antibacterial ***,*** and *** are the two most susceptible Gram-negative pathogens in aquaculture,and the economic losses caused by these two bacteria are immeasurable every *** results not only elucidate the mechanism of the lncRNAmiRNA-mRNA axis in antibacterial immune responses,but also provide new insights for understanding the impact of lncRNA on host immunity and bacteria escape.

关键词： antibacterial Fish Innate immunity lncRNA microRNA Precursor

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antibacterial POLY(D,L-LACTIDE)(PDLLA)FIBROUS MEMBRANES MODIFIED WITH QUATERNARY AMMONIUM MOIETIES

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Chinese Journal of Polymer Science 2010年第4期28卷 581-588页

作者：李新松 K.G.Neoh School of Chemistry and Chemical Engineering Southeast University Department of Chemical and Biomolecular Engineering National University of Singapore

antibacterial poly（D,L-lactide）（PDLLA） fibrous membranes were developed via electrospinning, followed by surface modification which involved plasma pretreatment, UV-induced graft copolymerization of 4-vinylpyridine （4VP） and quaternization of the grafted pyridine groups with hexylbromide. The success of modification with quaternized pyridinium groups on the PDLLA fibrous membranes was ascertained by X-ray photoelectron spectroscopy （XPS）. The antibacterial activities of these membranes were assessed against Gram-positive Staphylococcus aureus （S. aureus） and Gram-negative Escherichia coli （E. coli）. The PDLLA fibrous membranes modified with quatemized pyridinium groups showed antibacterial efficiency against both bacteria as high as 99.999%. The results demonstrated that the antibacterial activity was based on the interaction of the positive charge of pyridinium group and negatively charged cell membrane of bacteria, resulting in loss of membrane permeability and cell leakage.

关键词： Poly(D,L-lactide) antibacterial Electrospinning Surface modification

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antibacterial ability and cytocompatibility of Cu-incorporated Ni–Ti–O nanopores on NiTi alloy

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Rare Metals 2019年第6期38卷 552-560页

作者： Jia-Ming Zhang Yong-Hua Sun Ya Zhao Yan-Lian Liu Xiao-Hong Yao Bin Tang Rui-Qiang Hang Research Institute of Surface Engineering College of Materials Science and Technology Taiyuan University of Technology

Nearly equiatomic nickel–titanium(NiTi) alloy is an ideal implant biomaterial because of its shape memory effect, superelasticity, low elastic modulus as well as other desirable ***, it is prone to infection because of its poor antibacterial *** present work incorporated Cu into Ni–Ti–O nanopores(NP–Cu) anodically grown on the NiTi alloy to enhance its antibacterial ability, which was realized through *** results show that incorporation of Cu(0.78 at%–2.37 at%)has little influence on the NP diameter, length and *** release level of Cu ions is in line with loadage which may be responsible for the improved antibacterial ability of the NiTi alloy to combat possible bacterial infection in ***, the NP–Cu shows better cytocompatibility and even can promote proliferation of bone marrow mesenchymal stem cells(BMSCs),up-regulate collagen secretion and extracellular matrix mineralization when compared with Cu-free *** antibacterial ability and cytocompatibility of the NP–Cu render them to be promising when serving as NiTi implant coatings.

关键词： Nickel–titanium alloy Nickel–titanium–oxygen nanopores Copper antibacterial ability Cytocompatibility

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antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO_(4) co-precipitates

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 340-350页

作者： Wei Zhang Boren Xu Caihong Gong Chunwang Yi Shen Zhang Key Laboratory of Sustainable Resources Processing and Advanced Materials of Hunan Province College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China National&Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources Hunan Normal UniversityChangsha 410081China

In this study,a facile and environmentally friendly method with low energy consumption for preparing nanoscale AgCl and BaSO4 co-precipitates(AgCl@BaSO_(4) co-precipitates)was developed based on the metathetical ***,the dried co-precipitates were melt-compounded with polyamide 6(PA6)resins at a specified mass ratio in a twin-screw *** results demonstrated that in the absence of any coating agent or carrier,the nanoparticles of AgCl@BaSO_(4) co-precipitates were homogeneously dispersed in the PA6 *** analysis showed that after the addition of AgCl@BaSO_(4) co-precipitates,the antibacterial performance,along with the flame-retardance and anti-dripping characteristics of PA6,was enhanced *** addition,the PA6 composites possessed high spinnability in producing pre-oriented yarn.

关键词： nano AgCl@BaSO_(4)co-precipitates antibacterial flame resistance PA6 composite PA6 yarn

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antibacterial, cytotoxicity and wound healing assessments of amine-functionalised zeolite Y

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Particuology 2019年第4期17卷 116-123页

作者： Muhammad Hariz Asraf Nik Ahmad Nizam Nik Malek Khairunadwa Jemon Nor Suriani Sani Mustapha Salisu Muhammad Department of Biosciences Faculty of Science Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia Centre for Sustainable Nanomaterials (CSNano) Ibnu Sina Institute for Scientific and Industrial Research (IS1-ISIR) Universiti Teknologi Malaysia 81310 UTMJohor Malaysia Office of Deputy Vice Chancellor (Research and Innovation) Universiti Teknologi Malaysia 81310 UTM Skudai Johor Malaysia

The antibacterial activities,cytotoxicity,and wound healing of amine(3-aminopropyltriethoxysilane (APTES))-functionalised zeolite Y against normal human fibroblast cells were *** characterisation of unmodified and amine-functionalised zeolites Y (Z,ZA 0.04,ZA 0.4,and ZA 0.6) by Fourier transform infrared spectroscopy,X-ray powder diffraction,and energy dispersive X-ray analysis proved that the APTES molecules were grafted onto the zeolite Y surface without distorting its framework *** amine-functionalised zeolite Y samples possessed antibacterial activities against several ATCC bacteria that were correlated with the increased amount of APTES on the zeolite Y ***,when a higher concentration of APTES was grafted on the zeolite Y,higher cytotoxicity was observed against the fibroblast *** the ZA 0.6 sample (zeolite Y functionalised with 0.6 M of APTES) had higher antibacterial activity,it was cytotoxic to the ***,the selection of an antibacterial agent for human treatment purposes must also consider its cytotoxicity effect against human cells to ensure it is biocompatible.

关键词： Zeolite Y Amine functionalised zeolite Functionalisation antibacterial agent Cytotoxicity

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antibacterial Properties of an Austenitic antibacterial Stainless Steel and Its Security for Human Body

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Journal of Materials Science & Technology 2007年第3期23卷 333-336页

作者： Ke YANG Manqi LV Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

An austenitic antibacterial stainless steel is reported in this paper. The very fine and dispersive ε-Cu precipitations in the matrix of the antibacterial steel after the antibacterial treatment endow the steel with antibacterial function. The antibacterial function is strong, long-term and broad-spectrum, and can be maintained even after repeated wear and long time dipping in water. The steel is safe for human body and could be used widely in daily application.

关键词： antibacterial Austenitic steel Body security

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antibacterial Characterization of Silver Nanoparticles against *** ATCC-15224

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Journal of Materials Science & Technology 2008年第2期24卷 192-196页

作者： M.Raffi F.Hussain T.M.Bhatti J.I.Akhter A.Hameed M.M.Hasan Department of Chemical and Materials Engineering Pakistan Institute of Engineering and Applied Sciences(PIEAS)Islamabad-45650Pakistan Department of Microbiology Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabadPakistan Central Analytical Facility Division Pakistan Institute of Nuclear Science and Technology(PINSTECH)Islamabad-45650Pakistan Physics Division Pakistan Institute of Nuclear Science and Technology(PINSTECH)Islamabad-45650Pakistan

Silver nanoparticles of mean size 16 nm were synthesized by inert gas condensation （IGC） method. Crystalline structure, morphology and nanoparticles size estimation were conducted by X-ray diffraction （XRD） and transmission electron microscopy （TEM）. antibacterial activity of these silver nanoparticles as a function of particles concentration against gram-negative bacterium Escherichia coli （E. coli） was carried out in liquid as well as solid growth media. Scanning electron microscopy （SEM） and TEM studies showed that silver nanoparticles after interaction with *** have adhered to and penetrated into the bacterial cells. antibacterial properties of silver nanoparticles are attributed to their total surface area, as a larger surface to volume ratio of nanoparticles provides more efficient means for enhanced antibacterial activity.

关键词： Silver Nanoparticles antibacterial Electron microscopy

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antibacterial Behavior of a Cu-bearing Type 200 Stainless Steel

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Journal of Materials Science & Technology 2012年第11期28卷 1067-1070页

作者： Li Nan Jinglong Cheng Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Shenyang University of Chemical TechnologyShenyang 110142China

A preliminary study was made on the antibacterial behavior of a newly designed Cu-bearing type 200 stainless steel by different methods including Vickers hardness measurement, electrochemical test and antibacterial test. The results showed that Cu-rich precipitations caused crucial factor for its excellent antibacterial capability, as the commercial type 200 stainless steel. by the saturated Cu in the steel matrix was not only a but also for its equivalent corrosion resistance as good

关键词： Stainless steel antibacterial Cu precipitation

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antibacterial hydroxyapatite coatings on titanium dental implants

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Frontiers of Materials Science 2023年第1期17卷 69-85页

作者： Ziming Liao Jingxuan Li Yimeng Su Fenyan Miao Xiumei Zhang Yu Gu Jingjing Du Ruiqiang Hang Yan Wei Weiyi Chen Di Huang Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Analytical&TestingCenter Hainan UniversityHaikou570028China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good ***,their ability to bind to neighboring bone is limited due to the lack of biological *** the same time,they show poor antibacterial ability which can easily cause bacterial infection and chronic inflammation,eventually resulting in implant *** preparation of composite hydroxyapatite coatings with antibacterial ability can effectively figure out these *** this review,the research status and development trends of antibacterial hydroxyapatite coatings constructed on titanium and its alloys are analyzed and *** review may provide valuable reference for the preparation and application of high-performance and multi-functional dental implant coatings in the future.

关键词： composite dental implant hydroxyapatite titanium antibacterial

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