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Novel antibacterial cellulose diacetate-based composite 3d scaffold as potential wound dressing

Journal of Materials Science & Technology 2021年第30期89卷 225-232页

作者： Wencheng Liang Mingli Jiang Junyong Zhang Xiaoming dou Yan Zhou Yun Jiang Li Zhao Meidong Lang Center of Photonics&Bio-Medical diagnosis School of ScienceEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering School of BiotechnologyEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering New World Institute of BiotechnologyEast China University of Science and TechnologyShanghai 200237China The Library of Zhejiang University of Technology Zhejiang University of TechnologyHangzhou 310023China

In this work,novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid(CdA/PEI/HA)composite three-dimension(3d)scaffolds were prepared through electrospinning and ***,CdA/PEI 2d composite nanofiber membranes were prepared by electrospinning,and then the CdA/PEI/HA 3d composite scaffolds were fabricated by post-processing and freeze-drying of CdA/PEI *** particular,HA was added to improve the biocompatibility of composite *** with CdA/PEI scaffolds,CdA/PEI/HA composite scaffolds showed higher water absorbing rate,higher water retention rate and higher mechanical ***,CdA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial ***/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CdA/PEI *** summary,antibacterial CdA/PEI/HA scaffolds could protect wound from bacterial infection,improve cellular behavior and accelerate wound ***,CdA/PEI/HA scaffolds could be potential application for wound dressing.

关键词： Cellulose diacetate Electrospinning 3d scaffold Wound dressing

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Stepwise 3d-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite Magnesium ion Microenvironment 3d scaffold Bone tissue regeneration

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3d printing of bio-instructive materials:Toward directing the cell

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Bioactive Materials 2023年第1期19卷 292-327页

作者： Piotr Stanisław Zielinski Pavan Kumar Reddy Gudeti Timo Rikmanspoel Małgorzata Katarzyna Włodarczyk-Biegun Polymer Science Zernike Institute for Advanced MaterialsUniversity of GroningenNijenborgh 49747 AGGroningenthe Netherlands Biotechnology Centre The Silesian University of TechnologyB.Krzywoustego 844-100GliwicePoland

Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance.3d printing is a powerful technique to create highly complex and multicomponent structures with well-defined architecture and *** this review paper,we explore extrusion-based 3d printing methods(EBP,i.e.,Near Field Electrospinning(NFES),Melt Electrowriting(MEW),Fused deposition Modeling(FdM),and extrusion bioprinting)in terms of their ability to produce scaffolds with bio-instructive *** material systems provide spatio-temporal guidance for cells,allowing controlled tissue regeneration and *** physical and biochemical cues introduced to the EBP scaffolds are evaluated in their ability to direct cell alignment,proliferation,differentiation,specific ECM production,and tissue *** indicate that the cues have different impacts depending on the material system,cell type used,or coexistence of multiple ***,they must be carefully chosen based on the targeted *** propose future directions in bio-instructive materials development,including such concepts as metamaterials,hybrid living materials,and 4d *** review gathers the knowledge essential for designing new materials with a controlled cellular response,fabrication of advanced engineered tissue,and developing a better understanding of cell biology,especially in response to the biomaterial.

关键词： Tissue engineering Additive manufacturing Melt electrowriting 3d scaffold Cell differentiation Biomaterials

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development of a 3d matrix for modeling mammalian spinal cord injury in vitro

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Neural Regeneration Research 2016年第11期11卷 1810-1815页

作者： Juan Felipe diaz Quiroz Yuping Li Conrado Aparicio Karen Echeverri department of Genetics Cell Biology and Development University of Minnesota Minneapolis MN USA Center for Biotechnology and Interdisciplinary Studies Rensselaer Polytechnic Institute Troy NY USA Minnesota dental Research Center for Biomaterials and Biomechanics Department of Restorative Sciences School of Dentistry University of Minnesota Minneapolis MN USA

Spinal cord injury affects millions of people around the world, however, limited therapies are available to improve the quality of life of these patients. Spinal cord injury is usually modeled in rats and mice using contusion or complete transection models and this has led to a deeper understanding of the molecular and cellular complexities of the injury. However, it has not to date led to development of successful novel therapies, this is in part due to the complexity of the injury and the difficulty of deciphering the exact roles and interactions of different cells within this complex environment. Here we developed a collagen matrix that can be molded into the 3d tubular shape with a lumen and can hence support cell interactions in a similar architecture to a spinal cord. We show that astrocytes can be successfully grown on this matrix in vitro and when injured, the cells respond as they do in vivo and undergo reactive gliosis, one of the steps that lead to formation of a glial scar, the main barrier to spinal cord regeneration. In the future, this system can be used to quickly assess the effect of drugs on glial scar protein activity or to perform live imaging of labeled cells after exposure to drugs.

关键词： nerve regeneration spinal cord injury 3d scaffold in vitro models astrocytes reactive gliosis neural regeneration

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Liquid flow in scaffold derived from natural source:experimental observations and biological outcome

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Regenerative Biomaterials 2022年第1期9卷 480-489页

作者： Elisabetta Salerno Giulia Orlandi Claudio Ongaro Alessandro d’Adamo Andrea Ruffini Gianluca Carnevale Barbara Zardin Jessika Bertacchini diego Angeli CNR-NANO S3 Research Center on Nanostructures and Biosystems at Surfaces Modena I-41125Italy department of Sciences and Methods for Engineering University of Modena and Reggio EmiliaReggio Emilia 42122Italy department of Surgery MedicineDentistry and Morphological Sciences with Interest in TransplantOncology and Regenerative MedicineUniversity of Modena and Reggio EmiliaModena 41125Italy dIEF-Engineering department“Enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy Institute of Science and Technology for Ceramics(ISTEC) National Research Council(CNR)Faenza 48018Italy

This study investigates the biological effects on a 3d scaffold based on hydroxyapatite cultured with MC3T3 osteoblasts in response to flow-induced shear stress(FSS).The scaffold adopted here(B-HA)derives from the biomorphic transformation of natural wood and its peculiar channel geometry mimics the porous structure of the *** the point of view of fluid dynamics,B-HA can be considered a network of micro-channels,intrinsically offering the advantages of a microfluidic *** work,for the first time,offers a description of the fluid dynamic properties of the B-HA scaffold,which are strongly connected to its *** features are necessary to determine the FSS ranges to be applied during in vitro studies to get physiologically relevant *** selected ranges of FSS promoted the elongation of the attached cells along the flow direction and early osteogenic cell *** data confirmed the ability of B-HA to promote the differentiation process along osteogenic ***,such a bioactive and naturally derived scaffold can be considered as a promising tool for bone regeneration applications.

关键词： fluid shear stress flow resistance hydroxyapatite 3d scaffold

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3d bioactive composite scaffolds for bone tissue engineering

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Bioactive Materials 2018年第3期3卷 278-314页

作者： Gareth Turnbull Jon Clarke Frederic Picard Philip Riches Luanluan Jia Fengxuan Han Bin Li Wenmiao Shu department of Biomedical Engineering Wolfson BuildingUniversity of Strathclyde106 RottenrowGlasgowG40NWUnited Kingdom department of Orthopaedic Surgery Golden Jubilee National HospitalAgamemnon StClydebankG814DYUnited Kingdom Orthopaedic Institute Department of Orthopaedic SurgeryThe First Affiliated HospitalSoochow UniversitySuzhouJiangsuPR China

Bone is the second most commonly transplanted tissue worldwide,with over four million operations using bone grafts or bone substitute materials annually to treat bone ***,significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma,cancer,infection and *** bioactive three-dimensional(3d)scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering(BTE).A variety of materials and manufacturing methods including 3d printing have been used to create novel alternatives to traditional bone ***,individual groups of materials including polymers,ceramics and hydrogels have been unable to fully replicate the properties of bone when used *** material properties can be combined and bioactivity improved when groups of materials are used together in composite 3d *** review will therefore consider the ideal properties of bioactive composite 3d scaffolds and examine recent use of polymers,hydrogels,metals,ceramics and bio-glasses in *** fabrication methodology,mechanical performance,biocompatibility,bioactivity,and potential clinical translations will be discussed.

关键词： Bioactive composites 3d scaffold 3d printing Bioprinting Bone Tissue engineering

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