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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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垂直排列的六方氮化硼基忆阻器中的突触可塑性

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science China Materials 2024年第6期67卷 1907-1914页

作者：张海忠巨鑫江海涛杨丹魏榕山胡炜卢孝强朱敏敏 College of Physics and Information Engineering Fuzhou UniversityFuzhou 350116China Fuzhou University-Jinjiang Joint Institute of Microelectronics School of Advanced ManufacturingJinjiang Science and Education ParkFuzhou UniversityJinjiang 362200China Institute of Materials Research and Engineering Agency for ScienceTechnology and ResearchSingapore 138634Singapore

下一代计算系统需要实现每秒1018次浮点运算以解决感知终端数据呈指数增长的问题,这是由人工智能和物联网的进步驱动的.即使超级计算机具备执行这些操作的能力,但当电子突触阵列达到与人类神经网络相当规模时,管理热耗散就成为一个重要... 详细信息

下一代计算系统需要实现每秒1018次浮点运算以解决感知终端数据呈指数增长的问题,这是由人工智能和物联网的进步驱动的.即使超级计算机具备执行这些操作的能力,但当电子突触阵列达到与人类神经网络相当规模时,管理热耗散就成为一个重要挑战.解决电子设备中热点问题的潜在方案之一是使用垂直排列的六方氮化硼(h-BN),这种材料以其高导热性而闻名.在本研究中,我们使用高功率脉冲磁控溅射技术开发了纹理化的h-BN薄膜.定向的h-BN薄膜的热导率约为随机定向对应物的354%.通过制备基于纹理化h-BN薄膜的电子突触,我们展示了该器件中的各种生物突触可塑性.我们的研究结果表明,通过方向工程,可以有效使h-BN成为一种适用的自散热层,从而为未来可穿戴记忆设备、太阳能电池和神经形态器件铺平道路.

关键词： boron nitride vertically-aligned high thermal con-ductivity low-power memory neuromorphic computing

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Serum ceruloplasmin can predict liver fibrosis in hepatitis B virusinfected patients

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World Journal of Gastroenterology 2020年第27期26卷 3952-3962页

作者： Na-Ling Kang Jie-Min Zhang Meng-Xin Lin Xu-Dong Chen Zu-Xiong Huang Yue-Yong Zhu Yu-Rui Liu Da-Wu Zeng Liver Center The First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Pharmacy The First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Hospital of Quanzhou Affiliated with Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology the 910th Hospital of the People's Liberation ArmyQuanzhou 362000Fujian ProvinceChina Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina

BACKGROUND The presence of significant liver fibrosis in hepatitis B virus(HBV)-infected individuals with persistently normal serum alanine aminotransferase(PNALT)levels is a strong indicator for initiating antiviral *** ceruloplasmin(CP)is negatively correlated with liver fibrosis in HBV-infected *** To examine the potential value of serum CP and develop a noninvasive index including CP to assess significant fibrosis among HBV-infected individuals with *** Two hundred and seventy-five HBV-infected individuals with PNALT were retrospectively *** association between CP and fibrotic stages was statistically analyzed.A predictive index including CP[Ceruloplasmin hepatitis B virus(CPHBV)]was constructed to predict significant fibrosis and compared to previously reported *** Serum CP had an inverse correlation with liver fibrosis(r=-0.600).Using CP,the areas under the curves(AUCs)to predict significant fibrosis,advanced fibrosis,and cirrhosis were 0.774,0.812,and 0.853,*** CPHBV model was developed using CP,platelets(PLT),and HBsAg levels to predict significant *** AUCs of this model to predict significant fibrosis,advanced fibrosis,and cirrhosis were 0.842,0.920,and 0.904,*** was superior to previous models like the aspartate aminotransferase(AST)-to-PLT ratio index,Fibrosis-4 score,gamma-glutamyl transpeptidase-to-PLT ratio,Forn’s score,and S-index in predicting significant fibrosis in HBV-infected individuals with *** CPHBV could accurately predict liver fibrosis in HBV-infected individuals with ***,CPHBV can be a valuable tool for antiviral treatment decisions.

关键词： Ceruloplasmin Liver fibrosis Chronic hepatitis B infection Serum alanine aminotransferase Noninvasive model Receiver-operating characteristic

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Effects of microwave ablation on serum Golgi protein 73 in patients with primary liver cancer

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World Journal of Gastroenterology 2022年第29期28卷 3971-3980页

作者： Zheng-Ju Xu Mei-Juan Wei Xiao-Man Zhang Hui-Guo Liu Jin-Piao Wu Jin-Fa Huang Yong-Fei Li Zhi-Jie Huang Yan-Yan Yan The Liver Disease Center The 910th Hospital of the PLA Joint Logistics Support ForceQuanzhou 362000Fujian ProvinceChina Central Laboratory Decheng HospitalQuanzhou 362104Fujian ProvinceChina Central Laboratory of Clinical Hepatology The 910th Hospital of the PLA Joint Logistics Support ForceQuanzhou 362000Fujian ProvinceChina

BACKGROUND Microwave ablation(MWA)is an effective treatment option for patients with primary liver ***,it has been reported that the MWA procedure induces a hepatic inflammatory response and injury,which may negatively affect the efficacy of *** such,the discovery of reliable markers to monitor the patient’s response to MWA is *** protein 73(GP73)has been shown to be associated with chronic liver *** date,the potential value of serum GP73 in the dynamic monitoring during MWA of liver cancer remains *** To examine the effects of MWA on the serum levels of GP73 in patients with primary liver *** A total of 150 primary liver cancer patients with a single small lesion(≤3 cm in diameter)were retrospectively enrolled spanning the period between January 2016 and October *** of the patients received MWA for the treatment of primary liver *** GP73,alpha-fetoprotein(AFP),and widely used liver biochemical indicators[serum albumin,total bilirubin(TBIL),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)]were compared before MWA and at different time points,including 1,2,and 4 wk following the ablation *** Complete tumor ablation was achieved in 95.33%of the patients at 1 mo after *** 1-,2-,and 3-year disease-free survival rates were 74.67%,59.33%,and 54.00%,*** serum AFP levels were significantly decreased at 1,2,and 4 wk after MWA;they returned to the normal range at 12 wk after MWA;and they remained stable thereafter during follow-up in those cases without *** contrast,the serum GP73 levels were significantly increased at 1 and 2 wk after *** serum GP73 levels reached the peak at 2 wk after MWA,started to decline after hepatoprotective treatment with glycyrrhizin and reduced glutathione,and returned to the pretreatment levels at 12 and 24 wk after ***,the changes of serum GP73 in response to MWA were similar to those of TBIL,ALT,and ***

关键词： Liver cancer Microwave ablation Ablation therapy Golgi protein 73 Biomarker Liver injury

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An Effective Machine-Learning Based Feature Extraction/Recognition Model for Fetal Heart Defect Detection from 2D Ultrasonic Imageries

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Computer Modeling in Engineering & sciences 2023年第2期134卷 1069-1089页

作者： Bingzheng Wu Peizhong Liu Huiling Wu Shunlan Liu Shaozheng He Guorong Lv College of Engineering Huaqiao UniversityQuanzhou362021China Department of Ultrasound The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou362021China Collaborative Innovation Center forMaternal and Infant Health ServiceApplication technology QuanzhouMedical CollegeQuanzhou362021China

Congenital heart defect,accounting for about 30%of congenital defects,is the most common *** shows that congenital heart defects have seriously affected the birth rate of healthy *** Fetal andNeonatal Cardiology,medical imaging technology(2D ultrasonic,MRI)has been proved to be helpful to detect congenital defects of the fetal heart and assists sonographers in prenatal *** is a highly complex task to recognize 2D fetal heart ultrasonic standard plane(FHUSP)*** withmanual identification,automatic identification through artificial intelligence can save a lot of time,ensure the efficiency of diagnosis,and improve the accuracy of *** this study,a feature extraction method based on texture features(Local Binary Pattern LBP and Histogram of Oriented Gradient HOG)and combined with Bag of Words(BOW)model is carried out,and then feature fusion is ***,it adopts Support VectorMachine(SVM)to realize automatic recognition and classification of *** data includes 788 standard plane data sets and 448 normal and abnormal plane data *** with some other methods and the single method model,the classification accuracy of our model has been obviously improved,with the highest accuracy reaching 87.35%.Similarly,we also verify the performance of the model in normal and abnormal planes,and the average accuracy in classifying abnormal and normal planes is 84.92%.The experimental results show that thismethod can effectively classify and predict different FHUSP and can provide certain assistance for sonographers to diagnose fetal congenital heart disease.

关键词： Congenital heart defect fetal heart ultrasonic standard plane image recognition and classification machine learning bag of words model feature fusion

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Antibiotic resistance mechanisms of Myroides sp.

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2016年第3期17卷 188-199页

作者： Shao-huaHU Shu-xing YUAN Hai QU Tao JIANG Ya-jun ZHOU Ming-xi WANG De.song MING Yun Leung Laboratory for Molecular Diagnostics School of Biomedical Sciences and Institute of Molecular MedicineHuaqiao University/Engineering Research Center of Molecular MedicineMinistry of EducationXiamen 361021China Department of Neurosurgery Linyi People's Hospital Linyi 276000China Linyi Health School of Shandong Province Linyi 276000China Institute of Nanomedicine Department of Medical LaboratoryWeifang Medical CollegeWeifang 261053China Department of Clinical Laboratory Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362000China

Bacteria of the genus Myroides （Myroides spp.） are rare opportunistic pathogens. Myroides sp. infections have been reported mainly in China. Myroides sp. is highly resistant to most available antibiotics, but the resistance mechanisms are not fully elucidated. Current strain identification methods based on biochemical traits are unable to identify strains accurately at the species level. While 16S ribosomal RNA （rRNA） gene sequencing can accurately achieve this, it fails to give information on the status and mechanisms of antibiotic resistance, because the 16S rRNA sequence contains no information on resistance genes, resistance islands or enzymes. We hypothesized that ob- taining the whole genome sequence of Myroides sp., using next generation sequencing methods, would help to clarify the mechanisms of pathogenesis and antibiotic resistance, and guide antibiotic selection to treat Myroides sp. infec- tions. As Myroides sp. can survive in hospitals and the environment, there is a risk of nosocomial infections and pandemics. For better management of Myroides sp. infections, it is imperative to apply next generation sequencing technologies to clarify the antibiotic resistance mechanisms in these bacteria.

关键词： Myroides sp. Antibiotic resistance Identification methods 16S ribosomal RNA gene sequencing Nextgeneration sequencing

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