Effects of microwave ablation on serum Golgi protein 73 in patients with primary liver cancer
作者机构：The Liver Disease CenterThe 910th Hospital of the PLA Joint Logistics Support ForceQuanzhou 362000Fujian ProvinceChina Central LaboratoryDecheng HospitalQuanzhou 362104Fujian ProvinceChina Central Laboratory of Clinical HepatologyThe 910th Hospital of the PLA Joint Logistics Support ForceQuanzhou 362000Fujian ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第29期
页 面：3971-3980页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the Military Medical Science and Technology Committee of China,No.14MS095 the Quanzhou Science and Technology Planning Project,No.2017Z018
主 题：Liver cancer Microwave ablation Ablation therapy Golgi protein 73 Biomarker Liver injury
摘 要：BACKGROUND Microwave ablation(MWA)is an effective treatment option for patients with primary liver ***,it has been reported that the MWA procedure induces a hepatic inflammatory response and injury,which may negatively affect the efficacy of *** such,the discovery of reliable markers to monitor the patient’s response to MWA is *** protein 73(GP73)has been shown to be associated with chronic liver *** date,the potential value of serum GP73 in the dynamic monitoring during MWA of liver cancer remains *** To examine the effects of MWA on the serum levels of GP73 in patients with primary liver *** A total of 150 primary liver cancer patients with a single small lesion(≤3 cm in diameter)were retrospectively enrolled spanning the period between January 2016 and October *** of the patients received MWA for the treatment of primary liver *** GP73,alpha-fetoprotein(AFP),and widely used liver biochemical indicators[serum albumin,total bilirubin(TBIL),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)]were compared before MWA and at different time points,including 1,2,and 4 wk following the ablation *** Complete tumor ablation was achieved in 95.33%of the patients at 1 mo after *** 1-,2-,and 3-year disease-free survival rates were 74.67%,59.33%,and 54.00%,*** serum AFP levels were significantly decreased at 1,2,and 4 wk after MWA;they returned to the normal range at 12 wk after MWA;and they remained stable thereafter during follow-up in those cases without *** contrast,the serum GP73 levels were significantly increased at 1 and 2 wk after *** serum GP73 levels reached the peak at 2 wk after MWA,started to decline after hepatoprotective treatment with glycyrrhizin and reduced glutathione,and returned to the pretreatment levels at 12 and 24 wk after ***,the changes of serum GP73 in response to MWA were similar to those of TBIL,ALT,and ***
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