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Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice

Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 244-253页

作者： Venugopal R.Bovilla Preethi G.Anantharaju Sireesh Dornadula Prashanthkumar M.Veeresh Mahadevaswamy G.Kuruburu Vidya G.Bettada Kunka Mohanram Ramkumar SubbaRao V.Madhunapantula Center of Excellence in Molecular Biology and Regenerative Medicine Department of BiochemistryJSS Medical CollegeJSS Academy of Higher Education&ResearchMysore-570015KarnatakaIndia SRM research Institute Department of BiotechnologySchool of BioengineeringSRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia

Objective:To assess the nuclear factor-erythroid 2-related factor-2(Nrf2)modulatory effect of caffeic acid and protocatechuic acid and determine the anti-tumor activity of these phenolic compounds against Ehrlich ascites carcinoma growth in ***:Antioxidant activity of protocatechuic acid and caffeic acid was assessed using ferric reducing antioxidant power(FRAP)and 2,2-diphenyl-1-picrylhydrazyl(DPPH).Nrf2 activation potential of phenolic compounds was tested by quantitative realtime polymerase chain reaction,and luciferase complementation reporter *** vivo efficacy was tested using the Ehrlich ascites carcinoma ***:FRAP and DPPH radical scavenging assays showed that caffeic acid and protocatechuic acid were more potent compared with cinnamic acid and benzoic *** complementation reporter assays identified caffeic acid and protocatechuic acid as the activators of *** caffeic acid and protocatechuic acid upregulated the expression of Nrf2 target genes heme oxygenase-1(HO-1),glutamate-cysteine ligase catalytic subunit(GCLC),and glutamate-cysteine ligase modifier subunit(GCLM)and the activity of NAD(P)H:quinone oxidoreductase 1(NQO1)when tested on HCT-116 cells using a cell-based assay system at 9 *** addition,intraperitoneal administration of caffeic acid and protocatechuic acid to Ehrlich ascites carcinoma bearing mice suppressed tumor growth and ***:Caffeic acid and protocatechuic acid can modulate Nrf2 and inhibit Ehrlich ascites carcinoma cells.

关键词： Ehrlich ascites carcinomas Nrf2 Protocatechuic acid Caffeic acid NQO1 activity

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Ameliorative effect of alkaloid extract of Cyclea peltata(Poir.) Hook.f.& ***(ACP) on APAP/CC1_4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 143-151页

作者： Varghese Jancy Shine Panikamparambil Gopalakrishnan Latha Somasckharan Nair Rajam Suja Gangadharan Indira Anuja Gopan Raj Sreedharan Nair Rajasekharan Division of Ethnomedicine and Ethnopharmacology Jawaharlal Nehru Tropical Botanic Garden and Research Institute(JNTBGRI)TrivandrumKerala 695562India Deparment of Chemistry Sree Narayana CollegePunalurKollam- 691305KeralaIndia

Objective:To evaluate the hepatoprotective and antioxidant properties of alkaloid extract of Cyclea peltata(***) against paracetamol/carbon tetra chloride induced liver damage in Wistar ***:In viro paracetamol/carbon tetrachloride induced liver damage in Wistar rats,in vitro free radical scavenging studies,HPTLC estimation of letrandrine and direct analysis in real timemass spectrometry of alkaloid extract of *** were used for the ***:The results showed that pretreatment with alkaloid extract of *** caused significant reduction of serum glutamate pyruvate transaminase,serum glutamate oxaloacetate transaminase,serum alkaline phosphatase,serum cholesterol,liver malondialdehyde *** reduced glutathione,catalase,superoxide dismutase levels in liver were increased with alkaloid extract of *** *** results were almost comparable to silymarin and normal *** studies also substantiated the biochemical *** in vitro hydroxyl,superoxide and DPPH scavenging study of alkaloid extract of C. peltata showed significant free radical scavenging ***:The hepatoprotective property of alkaloid extract of *** against paracetamol/carbon tetrachloride may be due the synergistic action of alkaloids especially tetrandrine,fangchinoline through free radical scavenging and thus preventing oxidative stress.

关键词： Tetrandrine Glutathione Catalase Superoxide dismutase Hydroxyl Malondialdehyde

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Effect of Silver Nanoparticles on Growth of Eukaryotic Green Algae

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Nano-Micro Letters 2012年第3期4卷 158-165页

作者： Anjali Dash Anand P.Singh Bansh R.Chaudhary Sunil K.Singh Debabrata Dash Department of Biochemistry Institute of Medical SciencesBanaras Hindu University Centre of Advanced Study in Botany Banaras Hindu University

Silver nanoparticles,endowed with powerful antimicrobial property,are the most widely used nanomaterial in consumer products,with associated risk of their easy access to environment and freshwater ecosystems by surface *** toxic effects of nanosilver on bacterial,fungal and mammalian cells have been documented,its impact on algal growth remains *** oedogonia and Chara vulgaris are predominant members of photosynthetic eukaryotic algae,which form major component of global aquatic *** we report for the first time that nanosilver has significant adverse effects on growth and morphology of these filamentous green algae in a dose-dependent *** of algal thalli to increasing concentrations of silver nanoparticles resulted in progressive depletion in algal chlorophyll content,chromosome instability and mitotic disturbance,associated with morphological malformations in algal *** micrographs revealed dramatic alterations in cell wall in nanoparticle-treated algae,characterized with cell wall rupture and degradation in *** these observations underscore severe deleterious effects of nanosilver on aquatic environment,the information can also be exploited as a bioengineering strategy to control unwanted and persistent growth of noxious algal weeds that clog the municipal water supply and water channels and produce fouling of water bodies.

关键词： Silver nanoparticles Green algae Algal growth Photosynthetic pigment Nanotoxicity

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Tinospora cordifolia attenuates antipsychotic drug induced hyperprolactinemia in Wistar rats

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Asian pacific Journal of Reproduction 2019年第3期8卷 132-140页

作者： Prashant Tiwari Sunil Kumar Dubey Pratap Kumar Sahu Department of Pharmacology School of Pharmaceutical SciencesSiksha O Anusandhan(Deemed to be University)BhubaneswarOdisha751029India Department of Pharmacy Birla Institute of Technology and SciencePilaniIndia

Objective: To evaluate the anti-hyperprolactinemic effect of methanolic extract of Tinospora cordifolia against antipsychotic/neuroleptic drug induced hyperprolactinemia. Methods: A total of 48 Wistar albino rats were chosen in the study. To induce hyperprolactinemia, haloperidol at 5 mg/kg/day was intraperitoneally administered for 16 continuous days and sulpiride at 20 mg/kg/day was administered intraperitoneally for 28 continuous days. Methanolic extract of Tinospora cordifolia at 200 mg/kg/day and 400 mg/kg/day were administered orally 30 min before administration of haloperidol and sulpiride for 16 and 28 days, respectively. Then, we had evaluated prolactin, dopamine and antioxidant status in the treatment group as compared to haloperidol and sulpiride. Results: There was a significant (P<0.05) increase in serum prolactin level and decrease in dopamine level in the haloperidol and sulpiride treated animals. However, methanolic extract of Tinospora cordifolia significantly (P<0.05) decreased serum prolactin level and increased brain dopamine level. Further, superoxide dismutase and catalase level were also decreased significantly in the haloperidol and sulpiride treated groups as compared to those of the control group and the antioxidant status was restored significantly on treatment with methanolic extract of Tinospora cordifolia. Furthermore, methanolic extract of Tinospora cordifolia also reduced total leukocyte count, and increased red blood cell count and hemoglobin concentration. In addition, the spleen did not show signs of infection or inflammation in the experiments. Conclusions: Methanolic extract of Tinospora cordifolia has a significant anti-hyperprolactinemic effect which may be attributed to neuroprotective and antioxidant effects of its signature constituents like stepharanine.

关键词： Antipsychotic Neuroleptic Dopamine Prolactin Superoxide dismutase Catalase

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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5159-5183页

作者： Vivek Panwar Aishwarya Singh Manini Bhatt Rajiv K.Tonk Shavkatjon Azizov Agha Saquib Raza Shinjinee Sengupta Deepak Kumar Manoj Garg Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesShoolini UniversitySolanHimachal Pradesh173229India Amity Institute of Molecular Medicine and Stem Cell research(AIMMSCR) Amity University Uttar PradeshSector-125NoidaUttar Pradesh201313India Department of Biomedical Engineering Indian Institute of TechnologyRoparPunjab140001India Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)New Delhi110017India Laboratory of Biological Active Macromolecular Systems Institute of Bioorganic ChemistryAcademy of Sciences UzbekistanTashkent100125Uzbekistan Faculty of Life Sciences Pharmaceutical Technical University100084TashkentUzbekistan Rajive Gandhi Super Speciality Hospital TahirpurNew Delhi110093India

The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular *** mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating *** signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor *** emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human ***,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and ***,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR ***,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug ***,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.

关键词： metabolism homeostasis mTOR

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Renal gluconeogenesis in insulin resistance:A culprit for hyperglycemia in diabetes

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World Journal of Diabetes 2021年第5期12卷 556-568页

作者： Rajni Sharma Swasti Tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India

Renal gluconeogenesis is one of the major pathways for endogenous glucose *** in this process may contribute to hyperglycemia in cases with insulin resistance and *** reviewed pertinent studies to elucidate the role of renal gluconeogenesis regulation in insulin resistance and diabetes.A consensus on the suppressive effect of insulin on kidney gluconeogenesis has started to build ***-resistant models exhibit reduced insulin receptor(IR)expression and/or post-receptor signaling in their kidney *** IR expression or post-receptor signaling can cause impairment in insulin’s action on kidneys,which may increase renal gluconeogenesis in the state of insulin *** is now established that the kidney contributes up to 20%of all glucose production via gluconeogenesis in the post-absorptive ***,the rate of renal glucose release excessively increases in *** rise in renal glucose release in diabetes may contribute to fasting hyperglycemia and increased postprandial glucose *** glucose release by the kidneys and renal expression of the gluconeogenic-enzyme in diabetic rodents and humans further point towards the significance of renal ***,the available literature suggests that impairment in renal gluconeogenesis in an insulinresistant state may contribute to hyperglycemia in type 2 diabetes.

关键词： Renal gluconeogenesis Insulin-resistance Insulin Insulin receptor signaling Diabetes Gluconeogenic enzymes

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In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 364-367页

作者： Samuel Jacob Inbaneson Sundaram Ravikumar Palavesam Suganthi Department of Oceanography and Coastal Area Studies School of Marine SciencesAlagappa University

Objective:To identify the possible anliplasmodial compounds from Achyranlhes aspera(A. aspera).Acalypha indica(***),Jatropha glandulifera(***)and Phyllanlhus amarus(***).Methods:The ***,***,*** and *** were collected along Palk Strait and the extraction was carried out in *** filter sterilized extracts(100,50,25,12.5,6.25 and 3.125μg/mL) of leaf,stem,root and flower extracts of A aspera,A. indica,*** and *** were tested for anliplasmodial activity against Plasnuxlium *** potential extracts were also tested for their phytochemical ***: Of the selected plants species parts,the stem extract of *** showed excellent antiplasmodial activity(IC_(50)=43.81μg/mL) followed by stem extract of ***(IC_(50)= 49.14μg/mL).The stem extract of ***,leaf and root extracts of ***,leaf,root and seed extracts of J. glanduUfera and leaf and stem extracts of *** showed IC_(50),values between 50 and 100 μg/ *** analysis revealed that,significant antiplasmodial activity(P<0.0l) was observed between the concentrations and time of *** chemical injury to erythrocytes was also carried out and it showed that there were no morphological changes in erythrocytes by the elhanolic extract of all the tested plant *** in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,***,saponins,triterpenoids,proteins, and lannins in the elhanolic extracts of tested ***:The elhanolic stem extracts of *** and *** possess lead compounds for the development of antiplasmodial drugs.

关键词： Antiplasmodial activity IC50 Medicinal plants Phytochemicals Plasmodium falciparum Achyranthes aspera Acalypha indica Jatropha glandulifera Phyllanthus amarus

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Mycoendophytic diversity and their antimicrobial potential from two epiphytic orchids of the Western Ghats forests of India

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Studies in Fungi 2020年第1期5卷 113-124页

作者： Nuthan BR Rakshith D Marulasiddaswamy KM Ramesha KP Chandra Mohana N Sampath Kumara KK Satish S Department of Studies in Microbiology University of MysoreManasagangotriMysuru 570006KarnatakaIndia Department of Microbiology Yuvaraja’s CollegeUniversity of MysoreMysuru 570005KarnatakaIndia Department of Studies in Biotechnology University of MysoreManasagangotriMysuru 570006KarnatakaIndia Government Pre-University College Davangere 577002KarnatakaIndia

The epiphytic plants belong to a group that harmlessly grows on other plants by utilizing the nutrition from the host plants with their unique adaptation features along with symbiotic associations with fungi or *** various biological activities exhibited by the mycoendophytes inhabiting medicinally-important epiphytic orchids serve as the primary source of novel drug leads,industrially-essential enzymes,and plant growth-promoting *** the present study,a total of 956 culturable mycoendophytes out of 1600 segments belonging to 17 genera were isolated from different tissue parts of Trias stocksii and Dendrobium *** Xylariaceae taxa were the predominant mycoendophytes present in both plants,followed by Pestalotiopsis sp.,Colletotrichum sp.,and Fusarium *** estimation of the Shannon-Wiener and Simpson diversity indices showed that the bulbs of *** have the highest species diversity index and the stems of *** the *** highest species richness was observed in the leaves of *** and the lowest in the leaves of ***,*** harbored more mycoendophytes along with the highest diversity indices compared to *** antimicrobial evaluation revealed that Xylaria *** a higher potential of producing anti-infectives and opens a new arena for industrial exploration.

关键词： Antimicrobial activity Dendrobium herbaceum Diversity indices Mycoendophytes Trias stocksii Xylaria sp

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Anticancer property of sediment actinomycetes against MCF-7 and MDA-MB-231 cell lines

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 92-96页

作者： Ravikumar S Fredimoses M Gnanadesigan M School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623 409Ramanathapuram District Department of Biotechnology K.S.Rangasamy College of Arts & ScienceThiruchengodu- 637209Namakkal District

Objective:To investigate the anticancer property of marine sediment actinomvceles against two different breast cancer cell ***:In vitro anticancer activity was carried out against breast(MCF-7 and MDA-MB-231)cancer cell *** sequences of the 16s rRNA gene,phylogenetic tree construction,multiple sequence analysis and secondary structure analysis were also carried out with the actinomycetes ***:Of the selected five actinomycete isolates,ACT01 and ACT02 showed the IC_(50)value with(10.13±0.92)and(22.34±5.82)μg/mL concentrations,respectively for MCF-7 cell line at 48 h,but ACT01 showed the minimum(18.54±2.49μg/mL)level of IC_(50)value with MDA-MB-231 cell ***,the 16s rRNA partial sequences of ACT01,ACT02,ACT03,ACT04 and ACT05 isolates were also deposited in NCBI data bank with the accession numbers of GQ478246,GQ478247,GQ478248,GQ478249 and *** phylogenetic tree analysis showed that,the isolates of ACT02 and ACT03 were represented in groupⅠandⅢ,respectively,but ACT01 and ACT02 were represented in groupⅡ.The multiple sequence alignment of the actinomycete isolates showed that,the maximum identical conserved regions were identified with the nucleotide regions of 125 to 221st base pairs,65 to 119th base pairs and 55,48 and 31st base *** structure prediction of the 16s rRNA showed that,the maximum free energy was consumed with ACT03 isolate(-45.4 kkal/mol)and the minimum free energy was consumed with ACT04 isolate(-57.6 kkal/mol).Conclusions:The actinomycete isolates of ACT01 and ACT02(GQ478246 and GQ478247)which are isolated from sediment sample can be further used as anticancer agents against breast cancer cell lines.

关键词： Actinomyetes Breast cancer MCF-7 MDA-MB-231 Phylogenetic tree Anticancer property Multiple sequence analysis Secondary structure analysis Sediment Anticaner agent Cell line

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Inflammatory mediator release by Brugia malayi from macrophages of susceptible host Mastomys coucha and THP-1 and RAW 264.7 cell lines

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 92-96页

作者： Shiv Kumar Verma Vikas Kushwaha Vijaya Dubey Kirti Saxena Aakanksha Sharma Puvvada Kalpana Murthy Division of Parasitology Central Drug Research InstituteCSIRLucknow 226001India

Objective:To investigate which life stage of the parasite has the ability to stimulate release of pro- or anti-inflammatory mediators from ***:The human macrophage/ monocyte cell line THP-1,the mouse macrophage cell line RAW 264.7 and naive peritoneal macrophages（PM） from the rodent host Mastomys coucha（***） were incubated at 37℃in 5%CO2 atmosphere with extracts of microfilariae（Mf）,third stage infective larvae（L3） and adult worms（Ad） of Brugia *** 48 hr post exposure,IL-1β,IL-6,TNF-α,IL-10 and nitric oxide（NO） in cell-free supernatants were ***:Extracts of all the life stages of the parasite were capable of stimulating pro-（IL-1β,IL-6 and TNF-α） and anti-inflammatory （IL-10） cytokines in both the cell lines and peritoneal macrophages of *** was the strongest stimulator of pro-inflammatory cytokines followed by L3 and Ad;however,Ad was a strong stimulator of IL-10 *** was found to have potential to modulate LPS-induced NO release in RAW ***-induced NO release was concentration dependent with maximum at 20μg/mL in both RAW and ***:The results show that parasites at all life stages were capable of stimulating pro-（IL-1β,IL-6 and TNF-α） and anti-inflammatory（IL-10） cytokines and NO release from macrophages of susceptible host ***,human and mouse macrophage cell *** can suppress the LPS-induced NO release in RAW *** findings also show that the two cell lines may provide a convenient in vitro system for assaying parasite-induced inflammatory mediator release.

关键词： Cytokines Macrophage ThP-1 RAW 264.7 Brugia malayi Infective larva Microfilaria Adult worm Mastomys coucha

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