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Cellular and Transcriptional Dynamics during Brown Adipose Tissue Regeneration under Acute Injury

Research 2024年第3期2023卷 345-357页

作者： Wenjing You Ziye Xu Wentao Chen Xin Yang Shiqi Liu Liyi Wang Yuang Tu Yanbing Zhou Teresa G.Valencak Yizhen Wang Shihuan Kuang tizhong shan College of Animal Sciences Zhejiang UniversityHangzhouChina The Key Laboratory of Molecular Animal Nutrition Ministry of EducationHangzhouChina zhejiang Provincial Laboratory of Feed and Animal Nutrition HangzhouChina Department of Laboratory Medicine the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina Department of Animal Sciences Purdue UniversityWest LafayetteINUSA.

Brown adipose tissue(BAT)is the major site of non-shivering thermogenesis and crucial for systemic *** chronic cold exposures and high-fat diet challenges,BAT undergoes robust remodeling to adapt to physiological ***,whether and how BAT regenerates after acute injuries are poorly ***,we established a novel BAT injury and regeneration model(BAT-IR)in mice and performed single-cell RNA sequencing(scRNA-seq)and bulk RNA-seq to determine cellular and transcriptomic dynamics during *** further defined distinct fibro-adipogenic and myeloid progenitor populations contributing to BAT *** trajectory and gene expression analyses uncovered the involvement of MAPK,Wnt,and Hedgehog(Hh)signaling pathways in BAT *** confirmed the role of Hh signaling in BAT development through Myf5Cre-mediated conditional knockout(cKO)of the Sufu gene to activate Hh signaling in BAT and muscle *** BAT-IR model therefore provides a paradigm to identify conserved cellular and molecular mechanisms underlying BAT development and remodeling.

关键词： injuries involvement acute

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Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses

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Journal of Animal Science and Biotechnology 2021年第3期12卷 891-903页

作者： Jiaqi Liu Jie Li Wentao Chen Xintao Xie Xingang Chu Teresa G.Valencak Yizhen Wang tizhong shan College of Animal Sciences Zhejiang UniversityHangzhouChina Key Laboratory of Molecular Animal Nutrition(zhejiang university) Ministry of EducationHangzhouChina Key Laboratory of Animal Feed and Nutrition of zhejiang Province 866 Yuhangtang RoadHangzhouChina

Background:Meat quality is largely driven by fat deposition,which is regulated by several genes and signaling *** cyclic adenosine monophosphate(cAMP)-regulated transcriptional coactivator 3(CRTC3)is a coactivator of cAMP response element binding protein(CREB)that mediates the function of protein kinase A(PKA)signaling pathway and is involved in various biological processes including lipid and energy ***,the effects of CRTC3 on the metabolome and transcriptome of porcine subcutaneous adipocytes have not been studied ***,we tested whether porcine CRTC3 expression would be related to fat deposition in Heigai pigs(a local fatty breed in China)and Duroc×Landrace×Yorkshire(DLY,a lean breed)pigs in *** effects of adenovirus-induced CRTC3 overexpression on the metabolomic and transcriptomic profiles of subcutaneous adipocytes were also determined in vitro by performing mass spectrometry-based metabolomics combined with RNA sequencing(RNA-seq).Results:Porcine CRTC3 expression is associated with fat deposition in *** addition,CRTC3 overexpression increased lipid accumulation and the expression of mature adipocyte-related genes in cultured porcine subcutaneous *** to the metabolomic analysis,CRTC3 overexpression induced significant changes in adipocyte lipid,amino acid and nucleotide metabolites in *** RNA-seq analysis suggested that CRTC3 overexpression alters the expression of genes and pathways involved in adipogenesis,fatty acid metabolism and glycerophospholipid metabolism in ***:We identified significant alterations in the metabolite composition and the expression of genes and pathways involved in lipid metabolism in CRTC3-overexpressing *** results suggest that CRTC3 might play an important regulatory role in lipid metabolism and thus affects lipid accumulation in porcine subcutaneous adipocytes.

关键词： CRTC3 Energy metabolism Metabolomics Overexpression Subcutaneous adipocytes Transcriptomics

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Lipo-nutritional quality of pork:The lipid composition,regulation,and molecular mechanisms of fatty acid deposition

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Animal Nutrition 2023年第2期13卷 373-385页

作者： Wuzhou Yi Qixin Huang Yizhen Wang tizhong shan College of Animal Sciences Zhejiang UniversityHangzhouChina The Key Laboratory of Molecular Animal Nutrition Ministry of EducationHangzhouChina zhejiang Provincial Laboratory of Feed and Animal Nutrition HangzhouChina

Pork is one of the main meats consumed by people,and its nutritional value is closely related to human *** lipid deposition and composition of pork not only affect the sensory quality but also determine the nutritional quality of *** lipids in pork include triglycerides(TAG)and a small amount of cholesterol and *** are the main lipids in skeletal muscle fat,which is divided into intermuscular fat and intramuscular fat(IMF).In addition to TAG,IMF also contains phospholipids,which are important factors affecting pork *** are three types of fatty acids in TAG:saturated fatty acids(SFA),monounsaturated fatty acids(MUFA),and polyunsaturated fatty acids(PUFA).PUFA,such as n-3 PUFA,have a beneficial effect on health,including the regulation of whole-body energy metabolism and protection against cardiovascular ***,regulating lipid deposition,especially the fatty acid composition,in pork is important for improving the nutritional quality for hu-man ***,several strategies,such as breeding,environmental control,and the nutritional regulation of lipid composition and deposition in pork,have been *** recently,faecal trans-plantation,molecular design breeding and non-coding RNA have been studied and proven useful for regulating lipid deposition in *** this review,we mainly summarized and discussed the research findings to date on the lipid composition and regulation mechanisms of fatty acid deposition and provide new insights into efficient means of improving the lipid composition and lipo-nutritional quality of pork.

关键词： Fatty acid composition Intramuscular fat Dietary factor Gut microbiota Non-coding RNA

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