Cellular and Transcriptional Dynamics during Brown Adipose Tissue Regeneration under Acute Injury
作者机构：College of Animal SciencesZhejiang UniversityHangzhouChina The Key Laboratory of Molecular Animal NutritionMinistry of EducationHangzhouChina Zhejiang Provincial Laboratory of Feed and Animal NutritionHangzhouChina Department of Laboratory Medicinethe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina Department of Animal SciencesPurdue UniversityWest LafayetteINUSA.
出 版 物：《Research》 (研究（英文）)
年 卷 期：2024年第2023卷第3期
页 面：345-357页
核心收录：
学科分类：08[工学] 080101[工学-一般力学与力学基础] 0801[工学-力学（可授工学、理学学位）]
基 金：the National Key R&D Program of China(2018YFA0800403) the National Natural Science Foundation of China(31722053) the“Hundred Talents Program”funding from Zhejiang University to Tizhong Shan
主 题：injuries involvement acute
摘 要：Brown adipose tissue(BAT)is the major site of non-shivering thermogenesis and crucial for systemic *** chronic cold exposures and high-fat diet challenges,BAT undergoes robust remodeling to adapt to physiological ***,whether and how BAT regenerates after acute injuries are poorly ***,we established a novel BAT injury and regeneration model(BAT-IR)in mice and performed single-cell RNA sequencing(scRNA-seq)and bulk RNA-seq to determine cellular and transcriptomic dynamics during *** further defined distinct fibro-adipogenic and myeloid progenitor populations contributing to BAT *** trajectory and gene expression analyses uncovered the involvement of MAPK,Wnt,and Hedgehog(Hh)signaling pathways in BAT *** confirmed the role of Hh signaling in BAT development through Myf5Cre-mediated conditional knockout(cKO)of the Sufu gene to activate Hh signaling in BAT and muscle *** BAT-IR model therefore provides a paradigm to identify conserved cellular and molecular mechanisms underlying BAT development and remodeling.
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