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Catalyst–support Interaction in Polyaniline‑supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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Molecular simulation-guided and physics-informed mechanistic modeling of multifunctional polymers

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Acta Mechanica Sinica 2021年第5期37卷 725-745,I0002页

作者： Guang Chen Weikang Xian Qiming Wang Ying Li Department of Mechanical Engineering University of ConnecticutStorrsCT 06269USA Sonny Astani Department of Civil and Environmental Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Mechanical Engineering and Polymer Program Institute of Materials ScienceUniversity of ConnecticutStorrsCT 06269USA

Polymeric materials have a broad range of mechanical and physical *** have been widely used in material science,biomedical engineering,chemical engineering,and mechanical *** introduction of active elements into the soft matrix of polymers has enabled much more diversified functionalities of polymeric materials,such as self-healing,electroactive,magnetosensitive,pH-responsive,and many *** further enable applications of these multifunctional polymers,a mechanistic modeling method is required and of great significance,as it can provide links between materials’micro/nano-structures and their macroscopic mechanical *** this goal,molecular simulation plays an important role in understanding the deformation and evolution of polymer networks under external loads and *** molecular insights provide physical guidance in the formulation of mechanistic-based continuum models for multifunctional *** this perspective,we present a molecular simulation-guided and physics-informed modeling framework for polymeric ***,the physical theory for polymer chains and their networks is briefly *** serves as the foundation for mechanistic-models of polymers,linking their chemistry,physics,and mechanics ***,the deformation of the polymer network is used to derive the strain energy density ***,the corresponding continuum models can capture the intrinsic deformation mechanisms of polymer *** then highlight several representative examples across multiphysics coupling problems to describe in detail for this proposed *** but not least,we discuss potential challenges and opportunities in the modeling of multifunctional polymers for future research directions.

关键词： Molecular simulation Multiphysics modeling Multiscale modeling Multifunctional polymers Soft Matter

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DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties： Application in simultaneous amplification-free analysis of multiple RNA species

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Nano Research 2018年第2期11卷 940-952页

作者： Kevin M. Koo Laura G. Carrascosa Matt Trau Centre for Personalized Nanomedicine Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland Brisbane Australia School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Australia

The intrinsic affinity of DNA molecules toward metallic ions can drive the specific formation of copper nanostructures within the nucleic acid helix structure in a sequence-dependent manner. The resultant nanostructures have interesting fluorescent and electrochemical properties, which are attractive for novel biosensing applications. However, the potential of using DNA-templated nano- structures for precision disease diagnosis remains unexplored. Particularly, DNA- templated nanostructures show high potential for the universal amplification-free detection of different RNA biomarker species. Because of their low cellular levels and differing species-dependent length and sequence features, simultaneous detection of different messenger RNAs, microRNAs, and long non-coding RNAs species with a single technique is challenging. Here, we report a contemporary technique for facile in situ assembly of DNA-templated copper nanoblocks （CuNBs） on various RNA species targets after hybridization-based magnetic isolation. Our approach circumvents the typical limitations associated with amplification and labeling procedures of current RNA assays. The synthesized CuNBs enabled amplification-free fM-level RNA detection with flexible fluorescence or electrochemical readouts. Furthermore, our nanosensing technique displays potential for clinical application, as demonstrated by non-invasive analysis of three diagnostic RNA biomarkers from a cohort of 10 prostate cancer patient urinary samples with 100%-concordance （quantitative reverse transcription- polymerase chain reaction （PCR） validation）. The good analytical performance and versatility of our method may be useful in both diagnostics and research fields.

关键词： prostate cancer RNA detection DNA-templated coppernanostTuctures amplification-free fluorescence detection electrochemical detection

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Modeling the relationship between gene expression and mutational signature

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Quantitative Biology 2023年第1期11卷 31-43页

作者： Limin Jiang Hui Yu Yan Guo Department of Internal Medicine Comprehensive Cancer CenterUniversity of New Mexico AlbuquerqueNM 87109USA

Background:Mutational signatures computed from somatic mutations,allow an in-depth understanding of tumorigenesis and may illuminate early prevention *** studies have shown the regulation effects between somatic mutation and gene expression ***:We hypothesized that there are potential associations between mutational signature and gene *** capitalized upon RNA-seq data to model 49 established mutational signatures in 33 cancer *** accuracy and area under the curve were used as performance measures in five-fold ***:A total of 475 models using unconstrained genes,and 112 models using protein-coding genes were selected for future inference *** independent gene expression dataset on lung cancer smoking status was used for validation which achieved over 80%for both accuracy and area under the ***:These results demonstrate that the associations between gene expression and somatic mutations can translate into the associations between gene expression and mutational signatures.

关键词： mutational signature gene expression support vector machine random forest extreme gradient boost

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Reproducibility and Validity of a Chinese Food Frequency Questionnaire

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Biomedical and Environmental Sciences 2010年第S1期23卷 1-38页

作者： Water WILLETT Kyoko HASEGAWA Department of Nutrition Harvard School of Public Health Kagawa Nutrition University

Objectives This study was design to develop a semi-quantitative Chinese Food Frequency Questionnaire （FFQ） and to conduct a validation study for the questionnaire. Methods Based on the survey experience in recent years, a new Chinese food frequency questionnaire （FFQ） with 149 items in 17 food categories was developed. A validation study on this new FFQ was conducted in Jiangsu and Beijing of China between 1999 and 2001. The period of study covered 1 year and the FFQ was validated by comparing with data obtained by a six repeated 24-hour recalls for 3 consecutive days, or a totally 18-day 24- hour recall throughout the year. A total of 271 healthy adult subjects were enrolled in the study. Food and nutrient intakes measured by the 18-day dietary recalls and food frequency questionnaires （FFQs） were computed in the national institute for Nutrition and Food Safety, China CDC using the existing nutrition database. The average daily intake of foods and nutrients over the 18-day recall was used to compare with FFQ1 and FFQ2, which was conducted at the beginning and the end of the year, respectively. All statistical analyses were carried out using SAS software version 6.12.

关键词： FFQ Reproducibility and Validity of a Chinese Food Frequency Questionnaire

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

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Frontiers of Chemical Science and Engineering 2022年第3期16卷 333-344页

作者： Xiangsheng Liu Hui Sun Xueqing Wang Huan Meng CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing100190China The cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking UniversityBeijing100191China

Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer *** major advance is the observation of immunological responses associated with nano-enabled hyperthermia,which introduces a new avenue,allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery,i.e.,long-lasting and/or systemic anti-tumor *** perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors receiving nano-enabled *** includes the discussion about underlying mechanism such as immunogenic cell death,which initiates a profound immunological chain *** order to propagate the immune activation as a viable therapeutic principle,we further discussed the tumor type-specific complexity in the immunological tumor microenvironment,including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.

关键词： nano-enabled hyperthermia immunogenic cell death heterogeneous immunological landscape tumor microenvironment

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Unlocking fast Li-ion transport in micrometer-sized Mn-based cation-disordered rocksalt cathodes

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Journal of Energy Chemistry 2024年第12期99卷 645-653页

作者： Yuchen Zhang Hao Chen Runze Yu Wei Yang Jia He Haoyang Li Xianhu Sun Zhengyan Lun School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Binzhou institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou 256606ShandongChina Department of Materials Science and Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055GuangdongChina

The development of cation-disordered rocksalt(DRX)cathodes has garnered worldwide attention due to their high capacity,broad chemical space and excellent structural ***,their low intrinsic Li-ion conductivity necessitates extensive particle pulverization,typically achieved through ball-milling process,which impedes large-scale *** this work,we present a proton-exchange assisted strategy to activate the Li-ion transport in Mn-based DRX ***-range spinel-like ordering is observed to form within the DRX matrix after the post treatment,which significantly enhances the intrinsic Li ion ***,more than 280 mAh g^(-1)discharge capacity can be delivered at a slow rate from micrometer-sized particles with an overall disordered cation arrangement,which retains more than150 m Ah g^(-1)when cycled at a very high rate of 2000 mA g^(-1).Furthermore,we also demonstrate that the electrochemical performance of the post-treated cathodes can be further optimized by fine-tuning the reaction parameters.

关键词： Cation-disordered rocksalt cathodes Partially-disordered spinel Proton-exchange Short-range order

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Challenges associated with numerical back analysis in rock mechanics

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 2058-2071页

作者： Gabriel Walton Sankhaneel Sinha Department of Geology and Geological Engineering Colorado School of MinesGoldenCO80401USA

Numerical back analysis is a valuable tool available to rock mechanics researchers and *** studies related to back analysis methods focused primarily on applications of increasingly sophisticated optimization algorithms(primarily machine learning algorithms)to rock mechanics *** methods have typically been applied to relatively simple problems;however,more complex back analyses continue to be conducted primarily through ad hoc manual trial-and-error *** paper provides a review of the basic concepts and recent developments in the field of numerical back analysis for rock mechanics,as well as some discussion of the relationship between back analysis and more broadly established frameworks for numerical *** challenges of flexible constraints,non-uniqueness,material model limitations,and disparate data sources are considered,and representative case studies are presented to illustrate their impacts on back *** role of back analysis(or“model calibration”)in bonded particle modelling(BPM),bonded block modelling(BBM),and synthetic rock mass(SRM)modelling is also considered,and suggestions are made for further studies on this topic.

关键词： Back analysis Numerical modelling Inversion Case studies

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A boronate-based modular assembly nanosystem to block the undesirable crosstalk between hepatic stellate cells and Kupffer cells

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Bioactive Materials 2023年第7期25卷 569-579页

作者： Huizhen Jia Ling Ding Ao Yu Weimin Tang Siyuan Tang Chuhan Zhang David Oupický Center for Drug Delivery and Nanomedicine Department of Pharmaceutical SciencesCollege of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198USA

Crosstalk between Kupffer cells(KCs)and hepatic stellate cells(HSCs)plays an important role in multiple liver disease conditions,including the formation of liver fibrosis in alcohol-associated liver disease(AALD).Therapeutic targeting of the KC-HSC crosstalk is a prime target for therapeutic ***,a novel modular nanosystem was designed and prepared through the self-assembly utilizing boric acid and catechol interactions to prepare polymers modified with a CXCR4-inhibiting *** polymers were used to encapsulate anti-miR-155 and to block the undesirable crosstalk between HSCs and KCs by downregulating miR-155 expression in KCs with the parallel inhibition of CXCR4 signaling in activated *** combined inhibition of miR-155 and CXCR4 at two different liver cell types achieved improved antifibrosis effects in a mouse model of AALD *** finding highlights the key role that blocking the undesirable crosstalk between HSCs and KCs plays in reversing AALD fibrosis as well as demonstrates a proof-of-concept approach for designing and constructing multifunctional delivery nanosystems using orthogonal functional modules based on the understanding of disease mechanisms.

关键词： Nanoparticles miRNA CXCR4 Liver fibrosis Undesirable crosstalk Modular assembly

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Topoisomerase I in Human Disease Pathogenesis and Treatments

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 166-171页

作者： Min Li Yilun Liu Department of cancer Genetics and Epigenetics Beckman Research Institute

Mammalian topoisomerase 1（TOP1） is an essential enzyme for normal ***1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA replication and transcription and thus block cell ***,this exact activity can covalently trap TOP1 on the DNA that could lead to cell death or mutagenesis,a precursor for *** is therefore important for cells to find a proper balance between the utilization of the TOP1 catalytic activity to maintain DNA topology and the risk of accumulating the toxic DNA damages due to TOP1 trapping that prevents normal cell *** an apparent contradiction to the negative attribute of the TOP1 activity to genome stability,the detrimental effect of the TOP1-induced DNA lesions on cell survival has made this enzyme a prime target for cancer therapies to kill fast-growing cancer *** addition,cumulative evidence supports a direct role of TOP1 in promoting transcriptional progression independent of its topoisomerase *** involvement of TOP1 in transcriptional regulation has recently become a focus in developing potential new treatments for a subtype of autism spectrum ***,the impact of TOP1 on human health is *** this review,we will summarize our current understandings on how TOP1 contributes to human diseases and how its activity is targeted for disease treatments.

关键词： Topoisomerase 1 cancer Autism Scleroderma DNA replication Transcription

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