Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

作     者：Xiangsheng Liu Hui Sun Xueqing Wang Huan Meng Xiangsheng Liu;Hui Sun;Xueqing Wang;Huan Meng

作者机构：CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing100190China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery SystemsSchool of Pharmaceutical SciencesPeking UniversityBeijing100191China 

出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)

年 卷 期：2022年第16卷第3期

页      面：333-344页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(Grant Nos.31671017 and 81872809) the startup funding support from The Cancer Hospital of the University of Chinese Academy of Sciences(CAS),Institute of Basic Medicine and Cancer(IBMC),CAS.HM thanks the start-up packages of NCNST,CAS 

主　　题：nano-enabled hyperthermia immunogenic cell death heterogeneous immunological landscape tumor microenvironment 

摘      要：Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer *** major advance is the observation of immunological responses associated with nano-enabled hyperthermia,which introduces a new avenue,allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery,i.e.,long-lasting and/or systemic anti-tumor *** perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors receiving nano-enabled *** includes the discussion about underlying mechanism such as immunogenic cell death,which initiates a profound immunological chain *** order to propagate the immune activation as a viable therapeutic principle,we further discussed the tumor type-specific complexity in the immunological tumor microenvironment,including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.