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Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration

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Neural Regeneration Research 2024年第6期19卷 1318-1324页

作者： Theodora Mourtzi Nasia Antoniou Christina Dimitriou Panagiotis Gkaravelas Georgia Athanasopoulou Panagiota Nti Kostantzo Olga Stathi Efthymia Theodorou Maria Anesti Rebecca Matsas Fevronia Angelatou Georgia Kouroupi Ilias Kazanis Laboratory of Developmental Biology Department of BiologyUniversity of PatrasPatrasGreece Laboratory of Cellular and Molecular Neurobiology-Stem Cells Hellenic Pasteur InstituteAthensGreece Department of Physiology School of MedicineUniversity of PatrasPatrasGreece

We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the“weaver”mouse,a model of progressive nigrostriatal ***,we extended our investigation in two clinically-relevant ***,we assessed the effects of BNN-20 on human induced pluripotent stem cell-derived neural progenitor cells and neurons derived from healthy and parkinsonian ***,we assessed if BNN-20 can boost the outcome of mouse neural progenitor cell intranigral transplantations in weaver mice,at late stages of *** found that BNN-20 has limited direct effects on cultured human induced pluripotent stem cell-derived neural progenitor cells,marginally enhancing their differentiation towards neurons and partially reversing the pathological phenotype of dopaminergic neurons generated from parkinsonian *** agreement,we found no effects of BNN-20 on the mouse neural progenitor cells grafted in the substantia nigra of weaver ***,the graft strongly induced an endogenous neurogenic response throughout the midbrain,which was significantly enhanced by the administration of microneurotrophin *** results provide straightforward evidence of the existence of an endogenous midbrain neurogenic system that can be specifically strengthened by ***,the lack of major similar activity on cultured human induced pluripotent stem cell-derived neural progenitors and their progeny reveals the in vivo specificity of the aforementioned pro-neurogenic effect.

关键词： adult neurogenesis BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent stem cells(iPSCs) neurotrophic factors Parkinson's disease substantia

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Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVILLANO Javier PRECIADO-GARBAYO Jorge SEVIL Francisco GUTIERREZ Juan JMARTiNEZ Sonia MARTiN-LOPEZ Miguel GONZALEZ-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics Labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

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Preparation and application of highly porous aerogel-based bioactive materials in dentistry

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Frontiers of Materials Science 2014年第1期8卷 46-52页

作者： Andrea KUTTOR Melinda SZALOKI TLinde RENTE Farkas KERENYI Jozsef BAKO Istvan FABIAN Istvan LAZAR Attila JENEI Csaba HEGEDUES Department of Prosthetic Dentistry and Biomaterials Faculty of Dentistry University of Debrecen 4012 Debrecen Hungary Aerogel Research Group Department of Inorganic and Analytical Chemistry Faculty of Science University of Debrecen 4010 Debrecen Hungary Department of Dental Biochemistry Faculty of Dentistry University of Debrecen 4012 Debrecen Hungary Department of Biophysics and Cell Biology Faculty of Medicine University of Debrecen 4012 Debrecen Hungary

In this study, the possibility of preparation and application of highly porous silica aerogel-based bioactive materials are presented. The aerogel was combined with hydroxyapatite and *** phosphate as bioactive and osteoinductive agents. The porosity of aerogels was in themesoporous region with a maximum pore diameter of 7,4 and 12.7 nm for the composite materials. The newly developed bioactive materials were characterized by scant electron microscopy. The in vitro biological effect of these modified surfaces was also tested on SAOS-2 osteogenic sarcoma cells by confocal laser scanning microscopy.

关键词： aerogel sol-gel technique bioactive matedal SAOS-2 cell

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Influence of wet activation of used inorganic binder on cyclically refreshed water glass moulding sands hardened by microwaves

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China Foundry 2016年第6期13卷 427-432页

作者： Mateusz Stachowicz Kazimierz Granat Department of Foundry Plastics and Automation Wroc?aw University of Technology

The paper presents the research results of using an innovative method to reclaim the waste moulding sands containing water glass. Two of the examined processes are connected with "dry" or "wet" activation of inorganic binder in waste moulding sand mixtures physically hardened by microwave radiation. The sand mixtures consisting of high-silica sand and water-glass with average molar module 2.5, were subjected to the following cyclical process: mixing the components, compacting, microwave heating, cooling-down, thermally loading the mould to 800 °C, cooling-down to ambient temperature, and knocking-out. After being knocked-out, the waste moulding sands were subjected to either dry or wet activation of the binder. To activate thermally treated inorganic binder, each of the examined processes employed the surface phenomenon usually associated to mechanical reclamation. The study also covered possible use of some elements of wet reclamation to rehydrate waste binder. To evaluate the effectiveness of the two proposed methods of waste binder activation, selected strength and technological parameters were measured. After each subsequent processing cycle, the permeability, tensile strength and bending strength were determined. In addition, the surface of activated sand grains was examined with a scanning electron microscope. Analysis of the results indicates that it is possible to re-activate the used binder such as sodium silicate, and to stabilize the strength parameters in both activation processes. Permeability of the refreshed moulding sands strongly depends on the surface condition of high-silica grains. The wet activation process by wetting and buffering knocked-out moulding sands in closed humid environment makes it possible to reduce the content of refreshing additive in water-glass. The moulding sands cyclically prepared in both processes do not require the addition of fresh high-silica sand. The relatively high quality achieved in the refreshed moulding sands allo

关键词： moulding sand reclamation water-glass microwave heating refreshing

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Insight into the antifungal mechanism of Neosartorya fischeri antifungal protein

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Protein & Cell 2015年第7期6卷 518-528页

作者： Mate Viragh Annamaria Marton Csaba Vizier Liliana Toth Csaba Vagvolgyi Florentine Marx Laszlo Galgoczy Department of Microbiology Faculty of Science and Informatics University of Szeged Szeged Hungary Institute of Biochemistry Biological Research Centre Hungarian Academy of Sciences Szeged Hungary Division of Molecular Biology Biocenter Innsbruck Medical University Innsbruck Austria

Small, cysteine-rich, highly stable antifungal proteins secreted by filamentous Ascomycetes have great po- tential for the development of novel antifungal strate- gies. However, their practical application is still limited due to their not fully clarified mode of action. The aim of this work was to provide a deep insight into the anti-fungal mechanism of Neosartorya fischeri antifungal protein （NFAP）, a novel representative of this protein group. Within a short exposure time to NFAP, reduced cellular metabolism, apoptosis induction, changes in the actin distribution and chitin deposition at the hyphal tip were observed in NFAP-sensitive Aspergillus nidulans. NFAP did show neither a direct membrane disrupting- effect nor uptake by endocytosis. Investigation of A. nidulans signalling mutants revealed that NFAP acti- vates the cAMP/protein kinase A pathway via G-protein signalling which leads to apoptosis and inhibition of polar growth. In contrast, NFAP does not have any in- fluence on the cell wall integrity pathway, but an un- known cell wall integrity pathway-independent mitogen activated protein kinase A-activated target is assumed to be involved in the cell death induction. Taken to- gether, it was concluded that NFAP shows similarities, but also differences in its mode of antifungal action compared to two most investigated NFAP-related pro-teins from Aspergillus giganteus and Penicillium chrysogenum.

关键词： Neosartorya fischeri antifungal protein,Aspergillus nidulans cAMP/Pka signalling Pkc/Mpksignalling antifungal mechanism

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Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka Norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza Department of Geophysics University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME Geoengineering Research Group University of MiskolcMiskolc-Egyetemváros3515Hungary Research Institute of Applied Earth Sciences University of MiskolcMiskolc-Egyetemváros3515Hungary

We present new quantitative model describing the pressure dependence of acoustic P-and S-wave *** that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure *** estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity *** is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are *** the number of exponential terms leads to highly nonlinear ill-posed inverse *** to this reason,we develop the spectral inversion method(SIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as *** characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity *** characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical *** gives the possibility to estimate the aspect ratios in terms of the characteristic pressures.

关键词： Multi-exponential rock physical model Spectral inversion method(SIM) Crack aspect ratio Characteristic pressures

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Diurnal variation of aethalometer correction factors and optical absorption assessment of nucleation events using multi-wavelength photoacoustic spectroscopy

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Journal of Environmental Sciences 2019年第9期31卷 96-109页

作者： Tibor Ajtai Gergely Kiss-Albert Noemi Utry Adam Toth Andras Hoffer Gabor Szabo Zoltan Bozoki Department of Optics and Quantum Electronics University of Szeged H-6720 Szeged Hungary Hilase Development Production Service and Trading Limited Szekesfehervar H-8000 Hungary MTA-SZTE Research Group on Photoacoustic Spectroscopy H-6720 Szeged Hungary ELI-HU Non-Profit Ltd H-6720 Szeged Hungary Department of Earth and Environmental Sciences University of Pannonia P.O. Box 158 Veszprem H-8201 Hungary MTA-PE Air Chemistry Research Group P.O. Box 158 Veszprem H-8201 Hungary

A field measurement campaign was carried out during the late winter and early spring of2015 in Budapest, the capital of Hungary. The size distribution(SD) and optical absorption of carbonaceous particulate matter(CPM) was measured online using a Scanning Mobility Particle Sizer(SMPS), a 7λ-aethalometer and an inhouse developed 4λ-Photoacoustic Spectrometer. Based on the SD data, the measurement period could be classified into days with and without new particle formation events(normal days and nucleation days),although particular nucleation-like events were observed on normal days as well. Three characteristic size modes were observed with CMDs of circa 15, 25 and 110 nm that corresponded to the nucleation, traffic and heating modes. Based on the temporal behavior of these modes both types of days were divided into distinctive daily periods(heating hours,traffic hours and nucleation hours). The optical absorption spectra(OAC and AAE) also displayed the same part of day behavior to that of SD. That way this paper is among the first to assess the optical response of urban nucleation events. Due to the simultaneous measurement of OAC by the 7λ-aethalometer and a 4λ-Photoacoustic Spectrometer, OAC was measured overall at 11 wavelengths. That way aethalometer correction factors(f and C)were determined at all aethalometer wavelengths using in situ reference photoacoustic measurements. correction factors were found to have both wavelength and time of the day variation. In the case of f, no clear trend could be observed, however, Cref values increased both as a function of wavelength.

关键词： Photoacoustic spectroscopy Aerosol Angstr?m exponent Aethalometer Nucleation Size distribution

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Efficient object location determination and error analysis based on barycentric coordinates

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Visual computing for Industry,Biomedicine,and Art 2020年第1期3卷 195-201页

作者： Andrea Bodonyi Roland Kunkli Faculty of Informatics University of DebrecenDebrecen H-4028Hungary Doctoral School of Informatics University of DebrecenDebrecen H-4028Hungary

In this paper,we propose an efficient computational method for converting local coordinates to world coordinates using specially structured coordinate *** problem in question is the computation of world coordinates of an object throughout a motion,assuming that we only know the changing coordinates of some fixed surrounding reference points in the local coordinate system of the *** proposed method is based on barycentric coordinates;by taking the aforementioned static positions as the vertices of a polyhedron,we can specify the coordinates of the object in each step with the help of barycentric *** approach can significantly help us to achieve more accurate results than by using other possible *** the paper,we describe the problem and barycentric coordinate-based solution in *** then compare the barycentric method with a technique based on transformation matrices,which we also tested for solving our *** also present various diagrams that demonstrate the efficiency of our proposed approach in terms of precision and performance.

关键词： Barycentric coordinates conversion Transformation coordinate systems Location

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Osmotic Stress Modulates the Balance between Exocytosis and Clathrin-Mediated Endocytosis in Arabidopsis thaliana

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Molecular Plant 2015年第8期8卷 1175-1187页

作者： Marta Zwiewka Tomasz Nodzynski Stephanie Robert Steffen Vanneste Jiri Friml Mendel Centre for Plant Genomics and Proteomics Central European Institute of Technology (CEITEC) Masaryk University Kamenice 5 CZ-625 00 BrnoCzech Republic Department of Plant Systems Biology VlB and Department of Plant Biotechnology and Bioinformatics Ghent University Technologiepark 927 9052 Gent Belgium Institute of Science and Technology (IST) Austria Am Campus 1 3400 Klosterneuburg Austria Present address: Department of Forest Genetics and Plant Physiology Swedish University of Agricultural Sciences/Ume~. Plant Science Center 901 83 UmeaSweden

The sessile life style of plants creates the need to deal with an often adverse environment, in which water availability can change on a daily basis, challenging the cellular physiology and integrity. Changes in os- motic conditions disrupt the equilibrium of the plasma membrane： hypoosmotic conditions increase and hyperosmotic environment decrease the cell volume. Here, we show that short-term extracellular osmotic treatments are closely followed by a shift in the balance between endocytosis and exocytosis in root mer- istem cells. Acute hyperosmotic treatments （ionic and nonionic） enhance clathrin-mediated endocytosis simultaneously attenuating exocytosis, whereas hypoosmotic treatments have the opposite effects. In addition to clathrin recruitment to the plasma membrane, components of early endocytic trafficking are essential during hyperosmotic stress responses. consequently, growth of seedlings defective in elements of clathrin or early endocytic machinery is more sensitive to hyperosmotic treatments. We also found that the endocytotic response to a change of osmotic status in the environment is dominant over the presum- ably evolutionary more recent regulatory effect of plant hormones, such as auxin. These results imply that osmotic perturbation influences the balance between endocytosis and exocytosis acting through clathrin- mediated endocytosis. We propose that tension on the plasma membrane determines the addition or removal of membranes at the cell surface, thus preserving cell integrity.

关键词： osmotic stress protein trafficking clathrin-mediated endocytosis auxin

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Factors Influencing Cities’ Publishing Efficiency

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Journal of Data and Information Science 2018年第3期3卷 43-80页

作者： Csomós György Department of Civil Engineering University of Debrecen

Purpose:Recently,a vast number of scientific publications have been produced in cities in emerging *** has long been observed that the publication output of Beijing has exceeded that of any other city in the world,including such leading centres of science as Boston,New York,London,Paris,and *** have suggested that,instead of focusing on cities'total publication output,the quality of the output in terms of the number of highly cited papers should be ***,in the period from 2014 to 2016,Beijing produced as many highly cited papers as Boston,London,or New *** this paper,another method is proposed to measure cities'publishing performance by focusing on cities'publishing efficiency(i.e.,the ratio of highly cited articles to all articles produced in that city).Design/methodology/approach:First,554 cities are ranked based on their publishing efficiency,then some general factors influencing cities'publishing efficiency are *** general factors examined in this paper are as follows:the linguistic environment of cities,cities'economic development level,the location of excellent organisations,cities'international collaboration patterns,and their scientific field ***,the paper examines the fundamental differences between the general factors influencing the publishing efficiency of the top 100 most efficient cities and the bottom 100 least efficient ***:Based on the research results,the conclusion can be drawn that a city's publishing efficiency will be high if meets the following general conditions:it is in a country in the Anglosphere-core;it is in a high-income country;it is home to top-ranked universities and/or world-renowned research institutions;researchers affiliated with that city most intensely collaborate with researchers affiliated with cities in the United States,Germany,England,France,Canada,Australia,and Italy;and the most productive scientific disciplines of highly cited articles are publi

关键词： Cities Publishing efficiency Spatial scientometrics Highly cited articles Web of Science

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