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Interaction between N-Phospho-Amino Acids and Nucleoside in Aqueous Medium

chinese Chemical Letters 2000年第5期11卷 407-408页

作者： Yu Fen ZHAO Jian Jun HU Yong JU (State Laboratory of Bioorganic Phosphorus Chemistry. Department of Chemislry. School of Life Science and Engineering. Tsinghua University. Beijing 100084) State Lab. Bioorg. Phosphorus Chem. Department of Chemistry Tsinghua University Beijing 100084 China

Nucleosides were phosphorylated with different N- (O, O-diisopropyl) phosphoryl amino acids to give nucleoside mono phosphates in aqueous solution. 2', 3', and 5'-isomers had been confirmed by comparison with authentic samples on the basis of HPLC analysis. The conversion percentage of nucleoside indicated that N- (O, O-diisopropyl) phosphoryl aspartic acid reacted with adenosine and guanosine at a much higher rate than other kinds of N- phosphoryl amino acids. while phosphorylation of cytidine and uridine was relatively easy by using N- (O, O-diisopropyl) phosphoryl threonine. The result could give some clue to the prebiotic code origin of nucleic acid and protein.

关键词： N-phospho-amino acids nucleoside mono phosphate phosphorylation uridylyl uridine (UpU) origin chemical evolution

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TiO_2-functionalized mesoporous materials for sensitive analysis of multi-phosphopeptides

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Science china Chemistry 2011年第8期54卷 1327-1333页

作者： GUO WeiChao WAN JingJing QIAN Kun YU ChengZhong KONGJiLie YANG PengYuan LIU BaoHong Department of Chemistry and Institute of Biomedical Sciences Fudan University Shanghai 200433 China

Protein phosphorylation as one of the most important post-translational modifications in mammalian cells regulates numerous biological processes. Here we propose a novel strategy for the selective isolation and sensitive analysis of mul- ti-phosphopeptides based on TiO2-gratfed mesoporous materials, in which MCM-41 and SBA-15 were chosen as the hard templates. The commercialized IMAC and TiO2 nanopartices were further investigated in the phosphopeptide analysis for comparison. The enrichment efficiency was evaluated and measured by MALDI-TOF mass spectrometry. The results indicated that both TiO2-SBA-15 and TiO2-MCM-41 exhibited the preferential affinity to multi-phosphopeptides compared with the other two widely used strategies. The mesoporous TiO2 based protocol showed highly selective and sensitive properties, where phosphopepddes could be identified at femtomole.

关键词： TiO2 mesoporous materials multi-phosphopeptides enrichment

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First Palladium-Catalyzed Addition of Organoboronic Acids to Allenes: A Magic Regioselectivity Switch by Using a Base or an Acid

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有机化学 2003年第Z1期23卷 210-210页

作者： MA Sheng-Ming JIAO Ning State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

　　Organoboronic acids enjoy high prestige in the metal-catalyzed C-C bond formations. The most notable progress is the rhodium- and nickel-catalyzed conjugate addition with unsaturated carbon-carbon bond, aldehydes,... 详细信息

关键词： conjugate addition

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