Interaction between N-Phospho-Amino Acids and Nucleoside in Aqueous Medium

作     者：Yu Fen ZHAO Jian Jun HU Yong JU (State Laboratory of Bioorganic Phosphorus Chemistry. Department of Chemislry. School of Life Science and Engineering. Tsinghua University. Beijing 100084) 

作者机构：Tsing Hua Univ Sch Life Sci & Engn Dept Chem State Lab Bioorgan Phosphorus Chem Beijing 100084 Peoples R China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2000年第11卷第5期

页      面：407-408页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This prqiect was supported by the National Natural Science Foundation of China, National Science Technology Committee of Chi 

主　　题：N-phospho-amino acids nucleoside mono phosphate phosphorylation uridylyl uridine (UpU) origin chemical evolution 

摘      要：Nucleosides were phosphorylated with different N- (O, O-diisopropyl) phosphoryl amino acids to give nucleoside mono phosphates in aqueous solution. 2 , 3 , and 5 -isomers had been confirmed by comparison with authentic samples on the basis of HPLC analysis. The conversion percentage of nucleoside indicated that N- (O, O-diisopropyl) phosphoryl aspartic acid reacted with adenosine and guanosine at a much higher rate than other kinds of N- phosphoryl amino acids. while phosphorylation of cytidine and uridine was relatively easy by using N- (O, O-diisopropyl) phosphoryl threonine. The result could give some clue to the prebiotic code origin of nucleic acid and protein.