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Characterization of E-cadherin expression in normal mucosa,dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 265-277页

作者： Hai-Ling Wang Xue-Ke Zhao Fu-You Zhou Xin Song Liu-Yu Li Gai-Rong Huang Qi-De Bao Ling-Ling Lei Hai-Jun Yang Li Li Rui-Hua Xu Ai-Li Li Xian-Zeng Wang Wen-Li Han Jing-Li Ren Li-Dong Wang State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Thoracic Surgery and Tumor Prevention Treatment Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of Geriatrics Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Oncology Anyang District HospitalAnyang 455000Henan ProvinceChina Department of Pathology Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of Pathology Linzhou Tumor HospitalLinzhou 456500Henan ProvinceChina Department of Thoracic Surgery Linzhou People's HospitalLinzhou 456500Henan ProvinceChina Department of Pathology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROuND Gastric cardia adenocarcinoma(GCA),which has been classified as type II adenocarcinoma of the esophagogastric junction in western countries,is of similar geographic distribution with esophageal squamous cell carcinoma in china,and even referred as"sister cancer"by Chinese *** molecular mechanism for GCA is largely *** studies have shown that decreased expression of E-cadherin is associated with the invasion and metastasis of multiple ***,the E-cadherin expression has not been well characterized in gastric cardia carcinogenesis and its effect on GCA *** To characterize E-cadherin expression in normal gastric cardia mucosa,dysplasia and GCA tissues,and its influence on prognosis for *** A total of 4561 patients with GCA were enrolled from our previously established GCA and esophageal cancer *** enrollment criteria included radical surgery for GCA,but without any radio-or chemo-therapy before *** GCA tissue from 4561 patients and matched adjacent normal epithelial tissue(n=208)and dysplasia lesions(n=156)were collected,and processed as tissue microarray for *** clinicopathological characteristics were retrieved from the medical records in hospital and follow-up was carried out through letter,telephone or home interview.E-cadherin protein expression was determined by two step ***–Meier and Cox regression analyses were used to correlate E-cadherin protein expression with survival of GCA *** Of the 4561 GCA patients,there were 3607 males with a mean age of 61.6±8.8 and 954 females with a mean age of 61.9±8.6 years,*** the lesions progressed from normal gastric cardia mucosa to dysplasia and GCA,the positive immunostaining rates for E-cadherin decreased significantly from 100%to 93.0%and 84.1%,respectively(R2=0.9948).Furthermore,E-cadherin positive immunostaining rate was significantly higher in patients at early stage(

关键词： E-cadherin expression Immunohistochemistry Gastric cardia adenocarcinoma Dysplasia Clinicopathological feature Prognosis

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Increased prognostic value of clinical–reproductive model in Chinese female patients with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第13期28卷 1347-1361页

作者： Dong-Yun Zhang Jian-Wei Ku Xue-Ke Zhao Hai-Yan Zhang Xin Song Hong-Fang Wu Zong-Min Fan Rui-Hua Xu Duo You Ran Wang Ruo-Xi Zhou Li-Dong Wang State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pathology Nanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Endoscopy The Third Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Pathology The First Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Medical Oncology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450052Henan ProvinceChina Department of Biology University of RichmondRichmondVA 23173United States

BACKGROuND In china,it has been well recognized that some female patients with esophageal squamous cell carcinoma(ESCC)have different overall survival(OS)time,even with the same tumor-node-metastasis(TNM)stage,challenging the prognostic value of the TNM system *** effective predictive model is needed to accurately evaluate the prognosis of female ESCC *** To construct a novel prognostic model with clinical and reproductive data for Chinese female patients with ESCC,and to assess the incremental prognostic value of the full model compared with the clinical model and TNM *** A new prognostic nomogram incorporating clinical and reproductive features was constructed based on univariatie and Cox proportional hazards survival analysis from a training cohort(n=175).The results were recognized using the internal(n=111)and independent external(n=85)validation *** capability of the clinical–reproductive model was evaluated by Harrell’s concordance index(C-index),Kaplan–Meier curve,time-dependent receiver operating characteristic(ROC),calibration curve and decision curve *** correlations between estrogen response and immune-related pathways and some gene markers of immune cells were analyzed using the TIMER 2.0 *** A clinical–reproductive model including incidence area,age,tumor differentiation,lymph node metastasis(N)stage,estrogen receptor alpha(ESR1)and beta(ESR2)expression,menopausal age,and pregnancy number was constructed to predict OS in female ESCC *** to the clinical model and TNM stage,the time-dependent ROC and C-index of the clinical–reproductive model showed a good discriminative ability for predicting 1-,3-,and 5-years OS in the primary training,internal and external validation *** on the optimal cut-off value of total prognostic scores,patients were classified into high-and low-risk groups with significantly different *** estrogen response was significantly associated with p53 and apop

关键词： Esophageal squamous cell carcinoma Female Nomogram Prognosis Estrogen receptor

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Preoperative maximal voluntary ventilation,hemoglobin,albumin,lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2021年第4期27卷 321-335页

作者： Shou-Jia Hu Xue-Ke Zhao Xin Song Ling-Ling Lei Wen-Li Han Rui-Hua Xu Ran Wang Fu-You Zhou Liang Wang Li-Dong Wang State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Thoracic Surgery Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of Tumor Biology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States

BACKGROuND Preoperative pulmonary function plays an important role in selecting surgical candidates and assessing postoperative *** pulmonary function is associated with poor survival in several cancers,but the prognostic value of preoperative pulmonary function in esophageal squamous cell carcinoma(ESCC)is *** and systemic inflammation parameters are vital to cancer survival,and the combination of these parameters improves the prognostic *** hemoglobin,albumin,lymphocytes and platelets(HALP)score is a novel prognostic indicator to reflect the nutritional and inflammation status,but the clinical effects of the HALP score combined with maximal voluntary ventilation(MVV),an important parameter of pulmonary function,have not been well studied in *** To investigate the prognostic value of MVV and HALP score for assessing postoperative survival of ESCC *** Data form 834 ESCC patients who underwent radical esophagectomy with R0 resection were collected and retrospectively *** MVV and HALP data were retrieved from medical *** HALP score was calculated by the formula:Hemoglobin(g/L)×albumin(g/L)×lymphocytes(/L)/platelets(/L).The optimal cut-off values of MVV and HALP score were calculated by the receiver operating characteristic curve *** Kaplan-Meier method with log-rank test was used to draw the survival curves for the variables *** Cox proportional hazard regression models were used to analyze the independent prognostic factors for overall *** MVV was significantly associated with gender(Pumor length(P=0.013),tumor location(P=0.037)and treatment type(P=0.001).The HALP score was notably associated with gender(Pumor length(Punivariate Cox regression analysis showed that low MVV and low HALP score we

关键词： Maximal voluntary ventilation Hemoglobin,albumin,lymphocytes and platelets score Nutritional status Inflammation status Postoperative survival Esophageal squamous cell carcinoma

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Development and validation of a prognostic nomogram model for Chinese patients with primary small cell carcinoma of the esophagus

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World Journal of Clinical Cases 2021年第30期9卷 9011-9022页

作者： Dong-Yun Zhang Gai-Rong Huang Jian-Wei Ku Xue-Ke Zhao Xin Song Rui-Hua Xu Wen-Li Han Fu-You Zhou Ran Wang Meng-Xia Wei Li-Dong Wang Department of Pathology Nanyang Medical CollegeNanyang 473061Henan ProvinceChina State Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Geriatrics Henan People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Endoscopy of The Third Affiliated Hospital Nanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Thoracic Surgery Anyang Tumor HospitalAnyang 455000Henan ProvinceChina

BACKGROuND Primary small cell carcinoma of the esophagus(PSCE)is a highly invasive malignant tumor with a poor prognosis compared with esophageal squamous cell *** to the limited samples size and the short follow-up time,there are few reports on elucidating the prognosis of PSCE,especially on the establishment and validation of a survival prediction nomogram model covering general information,pathological factors and specific biological proteins of PSCE *** To establish an effective nomogram to predict the overall survival(OS)probability for PSCE patients in *** The nomogram was based on a retrospective study of 256 PSCE *** analysis and multivariate Cox proportional hazards regression analysis were used to examine the prognostic factors associated with PSCE,and establish the model for predicting 1-,3-,and 5-year OS based on the Akaike information *** and validation were assessed by the concordance index(C-index)and calibration curve and decision curve analysis(DCA).Histology type,age,tumor invasion depth,lymph node invasion,detectable metastasis,chromogranin A,and neuronal cell adhesion molecule 56 were integrated into the *** The C-index was prognostically superior to the 7th tumor node metastasis(TNM)staging in the primary cohort[0.659(95%CI:0.607-0.712)vs 0.591(95%CI:0.517-0.666),P=0.033]and in the validation cohort[0.700(95%CI:0.622-0.778)vs 0.605(95%CI:0.490-0.721),P=0.041].Good calibration curves were observed for the prediction probabilities of 1-,3-,and 5-year OS in both *** analysis showed that our nomogram model had a higher overall net benefit compared to the 7th TNM *** Our nomogram can be used to predict the survival probability of PSCE patients,which can help clinicians to make individualized survival predictions.

关键词： Primary small cell carcinoma Decision curve analysis Esophagus Nomogram Prognosis

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Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes

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Cancer Biology & Medicine 2020年第1期17卷 218-226页

作者： Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052China Department of Thoracic Surgery Anyang Tumor HospitalAnyang 455000China Department of Histology and Embryology School of Basic Medical SciencesXinxiang Medical UniversityXinxiang 453000China Department of Thoracic Surgery Linzhou People's HospitalLinzhou 456550China Department of Pathology and Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450000China Department of Pathology Linzhou Esophageal Cancer HospitalLinzhou 456550China Department of Oncology Nanyang Central HospitalNanyang 473000China Department of Thoracic Surgery Xinxiang Central HospitalXinxiang 453000China Department of Oncology Anyang District HospitalAnyang 455000China Department of Thoracic Surgery Linzhou Center HospitalLinzhou 456550China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Gastroenterology The Second Affiliated Hospital of Nanyang Medical CollegeNanyang 473000China Department of Pathology Anyang Tumor HospitalAnyang 455000China Department of Radiotherapy The Affiliated Cancer Hospital of Zhengzhou University(Henan Cancer Hospital)Zhengzhou 450000China Department of Pathology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Pathology Hebei Provincial Cixian People's HospitalCixian 056500China

Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC ***: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and ***: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients.

关键词： Cervical esophageal cancer survival esophagectomy radiochemotherapy

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