Increased prognostic value of clinical–reproductive model in Chinese female patients with esophageal squamous cell carcinoma
作者机构：State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated HospitalZhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of PathologyNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of EndoscopyThe Third Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of PathologyThe First Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Medical OncologyAffiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450052Henan ProvinceChina Department of BiologyUniversity of RichmondRichmondVA 23173United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第13期
页 面：1347-1361页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.81872032 and No.U1804262 National Key R&D Program of China,No.2016YFC0901403 High-Tech Key Projects of High School of Henan Province,No.20B320011 High-Tech Key Projects of Science and Technology of Henan Province Government,No.202102310366
主 题：Esophageal squamous cell carcinoma Female Nomogram Prognosis Estrogen receptor
摘 要：BACKGROUND In China,it has been well recognized that some female patients with esophageal squamous cell carcinoma(ESCC)have different overall survival(OS)time,even with the same tumor-node-metastasis(TNM)stage,challenging the prognostic value of the TNM system *** effective predictive model is needed to accurately evaluate the prognosis of female ESCC *** To construct a novel prognostic model with clinical and reproductive data for Chinese female patients with ESCC,and to assess the incremental prognostic value of the full model compared with the clinical model and TNM *** A new prognostic nomogram incorporating clinical and reproductive features was constructed based on univariatie and Cox proportional hazards survival analysis from a training cohort(n=175).The results were recognized using the internal(n=111)and independent external(n=85)validation *** capability of the clinical–reproductive model was evaluated by Harrell’s concordance index(C-index),Kaplan–Meier curve,time-dependent receiver operating characteristic(ROC),calibration curve and decision curve *** correlations between estrogen response and immune-related pathways and some gene markers of immune cells were analyzed using the TIMER 2.0 *** A clinical–reproductive model including incidence area,age,tumor differentiation,lymph node metastasis(N)stage,estrogen receptor alpha(ESR1)and beta(ESR2)expression,menopausal age,and pregnancy number was constructed to predict OS in female ESCC *** to the clinical model and TNM stage,the time-dependent ROC and C-index of the clinical–reproductive model showed a good discriminative ability for predicting 1-,3-,and 5-years OS in the primary training,internal and external validation *** on the optimal cut-off value of total prognostic scores,patients were classified into high-and low-risk groups with significantly different *** estrogen response was significantly associated with p53 and apop
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