Characterization of E-cadherin expression in normal mucosa,dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis
作者机构：State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer ResearchThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Thoracic Surgery and Tumor Prevention TreatmentAnyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of GeriatricsHenan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of OncologyAnyang District HospitalAnyang 455000Henan ProvinceChina Department of PathologyAnyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of PathologyLinzhou Tumor HospitalLinzhou 456500Henan ProvinceChina Department of Thoracic SurgeryLinzhou People's HospitalLinzhou 456500Henan ProvinceChina Department of PathologyThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2022年第14卷第1期
页 面：265-277页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China,No.81872032 No.U1804262 National Key R&D Program of China,No.2016YFC0901403
主 题：E-cadherin expression Immunohistochemistry Gastric cardia adenocarcinoma Dysplasia Clinicopathological feature Prognosis
摘 要：BACKGROUND Gastric cardia adenocarcinoma(GCA),which has been classified as type II adenocarcinoma of the esophagogastric junction in western countries,is of similar geographic distribution with esophageal squamous cell carcinoma in China,and even referred assister cancerby Chinese *** molecular mechanism for GCA is largely *** studies have shown that decreased expression of E-cadherin is associated with the invasion and metastasis of multiple ***,the E-cadherin expression has not been well characterized in gastric cardia carcinogenesis and its effect on GCA *** To characterize E-cadherin expression in normal gastric cardia mucosa,dysplasia and GCA tissues,and its influence on prognosis for *** A total of 4561 patients with GCA were enrolled from our previously established GCA and esophageal cancer *** enrollment criteria included radical surgery for GCA,but without any radio-or chemo-therapy before *** GCA tissue from 4561 patients and matched adjacent normal epithelial tissue(n=208)and dysplasia lesions(n=156)were collected,and processed as tissue microarray for *** clinicopathological characteristics were retrieved from the medical records in hospital and follow-up was carried out through letter,telephone or home interview.E-cadherin protein expression was determined by two step ***–Meier and Cox regression analyses were used to correlate E-cadherin protein expression with survival of GCA *** Of the 4561 GCA patients,there were 3607 males with a mean age of 61.6±8.8 and 954 females with a mean age of 61.9±8.6 years,*** the lesions progressed from normal gastric cardia mucosa to dysplasia and GCA,the positive immunostaining rates for E-cadherin decreased significantly from 100%to 93.0%and 84.1%,respectively(R2=0.9948).Furthermore,E-cadherin positive immunostaining rate was significantly higher in patients at early stage(
维普期刊数据库