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Cancer mortality in serbia, 1991-2015: an age-period-cohort and joinpoint regression analysis

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Cancer Communications 2018年第1期38卷 120-135页

作者： Milena Ilic Irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacS.Markovica 69Kragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of serbia has experienced significant health *** aim of this study was to assess cancer mortality trends in ***:This nationwide study was carried out to analyze cancer mortality in serbia during 1991-2015 using offi-cial *** age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by *** average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression ***-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal ***:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in *** cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both *** almost all major cancers except stomach cancer,cancer mortality in serbia demonstrated upward trends during the study *** largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in *** this,these rates place serbia among the countries with the highest cancer mortality in the world.

关键词： Cancer Mortality Trend Joinpoint regression analysis Age-period-cohort analysis

Charge self-trapping in two strand biomolecules:Adiabatic polaron approach

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Chinese Physics B 2023年第1期32卷 253-263页

作者： D Chevizovich S Zdravković A V Chizhov Z Ivić University of Belgrade Vinča Institute of Nuclear SciencesP.O.Box 522Belgrade 11001Serbia Joint Institute for Nuclear Research Laboratory for Radiation BiologyDubna 141980Russia Dubna State University Dubna 141980Russia Department of Physics University of CreteP.O.Box 2208Heraklion 71003Greece National University of science and Technology MISiS Leninsky prosp.4Moscow 119049Russia

We investigate the properties of the excess charge(electron, hole) introduced into a two-strand biomolecule. We consider the possibility that the stable soliton excitation can be formed due to interaction of excess charge with the phonon subsystem. The influence of overlap of the molecular orbitals between adjacent structure elements of the macromolecular chain on the soliton properties is discussed. Special attention is paid to the influence of the overlapping of the molecular orbitals between structure elements placed on the different chains. Using the literature values of the basic energy parameters of the two-chain biomolecular structures, possible types of soliton solutions are discussed.

关键词： charge self-trapping adiabatic polaron soliton two-stranded biomolecules

Improved degradation of azo dyes by lignin peroxidase following mutagenesis at two sites near the catalytic pocket and the application of peroxidase-coated yeast cell walls

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Frontiers of Environmental science & Engineering 2021年第2期15卷 33-42页

作者： Karla IlićĐurđić Raluca Ostafe Olivera Prodanović AleksandraĐurđevićĐelmaš Nikolina Popović Rainer Fischer Stefan Schillberg Radivoje Prodanović University of Belgrade-Faculty of Chemistry Studentski trg 12-1611000 BelgradeSerbia Molecular Evolution Protein Engineering and Production facility(MEPEP) Purdue UniversityWest LafayetteIN 47907USA Institute of Molecular Biotechnology RWTH Aachen University52074 AachenGermany Institute for Multidisciplinary Research Kneza Višeslava 111030 BelgradeSerbia Departments of Biological sciences and Chemistry Purdue UniversityWest LafayetteIN 47907USA Fraunhofer Institute for Molecular Biology and Applied Ecology IME 52074 AachenGermany

The enzymatic degradation of azo dyes is a promising alternative to ineffective chemical and physical remediation *** peroxidase(LiP)from Phanerochaete chrysosporium is a hemecontaining lignin-degrading oxidoreductase that catalyzes the peroxide-dependent oxidation of diverse molecules,including industrial *** enzyme is therefore ideal as a starting point for protein ***,we subjected two positions(165 and 264)in the environment of the catalytic Trp171 residue to saturation mutagenesis,and the resulting library of 104 independent clones was expressed on the surface of yeast *** yeast display library was used for the selection of variants with the ability to break down structurally-distinct azo dyes more *** identified mutants with up to 10-fold greater affinity than wild-type LiP for three diverse azo dyes(Evans blue,amido black 10B and Guinea green)and up to 13-fold higher catalytic ***,cell wall fragments displaying mutant LiP enzymes were prepared by toluene-induced cell lysis,achieving significant increases in both enzyme activity and stability compared to a whole-cell *** cell wall fragments retained their initial dye degradation activity after 10 reaction cycles each lasting 8 *** best-performing mutants removed up to 2.5-fold more of each dye than the wild-type LiP in multiple reaction cycles.

关键词： Bioremediation Enzyme immobilization Protein engineering Yeast surface display

Preparatory training attenuates drastic response of the insulin-like growth factor binding protein 1 at the point of maximal oxygen consumption in handball players

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Journal of Sport and Health science 2017年第3期6卷 372-377页

作者： Olgica Nedic Milos Sunderic Goran Miljus Zoran Valdevit Vladimir Jakovljevic Marija Glibetic Vesna Vucic Institute for the Application of Nuclear Energy University of BelgradeBelgrade 11080Serbia Faculty of Sport and Physical Education University of BelgradeBelgrade 11000Serbia Department of Physiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Centre of Research Excellence in Nutrition and Metabolism Institute for Medical ResearchUniversity of BelgradeBelgrade 11000Serbia

Background:Intensive exercise changes physiological need for glucose and several biochemical pathways responsible for its metabolism *** them are those which involve insulin,insulin-like growth factor(IGF-1),and IGF-binding proteins(IGFBPs).Different types and degrees of exercise,as well as an athlete's fitness,may induce a range of responses regarding concentrations and time needed for the *** idea of the work was to find out whether and how insulin/IGF axis responds to additional physical activity in the already trained subjects and if so,is the adaptation potentially beneficial from the aspect of metabolic ***:The effect of 4-week intensive training on campus(preparatory training) on the levels of insulin,IGF-1,and IGFBPs during maximal progressive exercise test(MPET) on a treadmill was compared to the results obtained during MPET conducted after a regular training season of a female elite handball team(n = 17,age:17 ± 1 years,height:171 ± 8 cm,weight:65 ± 8 kg,body mass index:22 ± 1 kg/m^2 at the beginning of the study;there were no significant changes at the end).Serum samples were obtained from players immediately before the test(basal),at the end of the test after reaching the point of maximal oxygen consumption(VO_(2max)),and after ***:The concentration of insulin decreased at VO_(2max),but remained higher in players after preparatory training(12.2 ± 2.5 m U/L vs.8.9 ± 4.4 m U/L,p = 0.049).The level of IGFBP-1 decreased in players at VO_(2max) in either case of training,but it remained much higher in tests performed after the preparatory regime than before(p = 0.029).Concentrations of IGF-1,IGFBP-2,-3,and-4 did not change ***:The inverse relation between insulin and IGFBP-1 was lost during MPET,as these 2 molecules changed in the same *** results obtained suggest less severe stress-induced depression of insulin and IGFBP-1 after preparatory *** another metabolic mechanism

关键词：女性 IGF 有约束力的蛋白质(IGFBP ) 胰岛素像胰岛素的生长因素我(IGF-1 ) 进步锻练测试 VO 2max

Channeling of fast ions through the bent carbon nanotubes： The extended two-fluid hydrodynamic model

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Chinese Physics B 2016年第4期25卷 274-283页

作者： Lazar Karbunar Dusko Borka Ivan Radovic Zoran L Miskovic School of Electrical Engineering University of Belgrade Bulevar Kralja Aleksandra 73 11120 Belgrade Serbia Vinca Institute of Nuclear sciences University of Belgrade P. O. Box 522 11001 Belgrade Serbia Department of Applied Mathematics and Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario Canada N2L 3G1

We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes （SWNTs） under channeling conditions in the presence of dynamic polarization of the valence electrons in carbon, This polarization is described by a cylindrical, two-fluid hydrodynamic model with the parameters taken from the recent modelling of several independent experiments on electron energy loss spectroscopy of carbon nano-structures. We use the hydrodynamic model to calculate the image potential for protons moving through four types of SWNTs at a speed of 3 atomic units. The image potential is then combined with the Doyle-Turner atomic potential to obtain the total potential in the bent carbon nanotubes. Using that potential, we also compute the spatial and angular distributions of protons channeled through the bent carbon nanotubes, and compare the results with the distributions obtained without taking into account the image potential.

关键词： nanotubes channeling dynamic polarization

Dental mesenchymal stromal/stem cells in different microenvironments— implications in regenerative therapy

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World Journal of Stem Cells 2021年第12期13卷 1863-1880页

作者： Ivana Okić-Đorđević Hristina Obradović Tamara Kukolj Anđelija Petrović Slavko Mojsilović Diana Bugarski Aleksandra Jauković Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Current research data reveal microenvironment as a significant modifier of physical functions,pathologic changes,as well as the therapeutic effects of stem *** comparing regeneration potential of various stem cell types used for cytotherapy and tissue engineering,mesenchymal stem cells(MSCs)are currently the most attractive cell source for bone and tooth regeneration due to their differentiation and immunomodulatory potential and lack of ethical issues associated with their *** microenvironment of donors and recipients selected in cytotherapy plays a crucial role in regenerative potential of transplanted MSCs,indicating interactions of cells with their microenvironment indispensable in MSC-mediated bone and dental *** a variety of MSC populations have been procured from different parts of the tooth and tooth-supporting tissues,MSCs of dental origin and their achievements in capacity to reconstitute various dental tissues have gained attention of many research groups over the *** review discusses recent advances in comparative analyses of dental MSC regeneration potential with regards to their tissue origin and specific microenvironmental conditions,giving additional insight into the current clinical application of these cells.

关键词： Microenvironment Dental mesenchymal stem cells Modulation of regenerative potential Tissue origin Hypoxia microenvironment Inflammatory microenvironment Clinical application

Spatial assessment of the areas sensitive to degradation in the rural area of the municipality (C)ukarica

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International Soil and Water Conservation Research 2019年第1期7卷 71-80页

作者： Natalija Momirovi(c) Ratko Kadovi(c) Veljko Perovi(c) Milo(s)Marjanovi(c) Aleksandar Baumgertel Institute of Forestry Kneza Vi(s)eslava 311030 BelgradeSerbia Faculty of Forestry University of BelgradeKneza Vi(s)eslava 111030 BelgradeSerbia Institute for Biological Research'Sini(s)a Stankovi(c)' University of BelgradeBulevar despota Stefana 14211060 BelgradeSerbia Faculty of Mining and Geology University of BelgradeDu(s)ina 711000 BelgradeSerbia

In this paper,the assessment of the sensitivity of the soil in the rural area of (C)ukarica municipality to the processes of degradation is *** areas,especially in the vicinity of large cities,are exposed to numerous processes of degradation:soil erosion,urban and industrial zone expansion at the expense of fertile agricultural soils,activation of landslides and a number of other significant ecological *** on the characteristics of the research area,the MEDALUS (Mediterranean Desertification and Land Use) model was applied,and for the assessment of sensitivity to the processes of degradation the main quality indicators were considered:soil,climate,vegetation and *** each of the analyzed quality indicators,parameter groups were *** parameter is quantified according to the defined method by giving them a sensitivity coefficient between 1.0 and *** 10.0 has been applied to analyze and prepare layers of quality ***,the geometric mean for all four quality indicators was used to generate the map of environmental sensitivity to *** results obtained show that 41.54% of the study area is classified as critical;22.34% of the surface as fragile;8.47% of the areas are potentially endangered and 9.58% not threatened to degradation *** results have also shown that MEDALUS model is a functional tool for simulations which support sustainable land management in the areas prone to degradation.

关键词： MEDALUS Land degradation Landslides Human pressures GIS mapping

Liver disease and COVID-19:The link with oxidative stress,antioxidants and nutrition

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World Journal of Gastroenterology 2021年第34期27卷 5682-5699页

作者： Danijela Ristic-Medic Snjezana Petrovic Aleksandra Arsic Vesna Vucic Group for Nutritional Biochemistry and Dietology Centre of Research Excellence in Nutrition and MetabolismNational Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2).In general,oxidative stress is actively involved in initiation and progression of liver *** liver metabolizes various compounds that produce free *** the oxidative/antioxidative balance is important in coronavirus disease 2019(COVID-19)*** vitamins,essential trace elements and food compounds,such as polyphenols,appear to be promising agents,with effects in oxidative *** of these nutrients suppresses immune function and increases susceptibility to *** micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary *** supplements(β-carotene,vitamin A,vitamin C,vitamin E,and selenium)could have a potential role in patients with liver *** evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of *** trials based on the associations of diet and SARS-CoV-2 infection are ***,it is not possible to definitively determine the dose,route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still *** then,hopefully,this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Liver injury Antioxidants Nutrients Treatment

Inflammatory niche:Mesenchymal stromal cell priming by soluble mediators

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World Journal of Stem Cells 2020年第9期12卷 922-937页

作者： Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić-Đorđević Slavko Mojsilović Diana Bugarski Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Mesenchymal stromal/stem cells(MSCs)are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell *** play a critical role in tissue homeostasis and wound healing,as well as in regulating the inammatory microenvironment through interactions with immune ***,MSCs have garnered great attention as promising candidates for tissue regeneration and cell *** the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs,priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these *** this paper,we review how soluble mediators of the inflammatory niche(cytokines and alarmins)influence the regenerative and immunomodulatory capacity of MSCs,highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed *** data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.

关键词： Mesenchymal stem cells Pro-inflammatory cytokines Alarmins Priming Boosting the therapeutic potential