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Liver disease and COVID-19:The link with oxidative stress,antioxidants and nutrition

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World Journal of Gastroenterology 2021年第34期27卷 5682-5699页

作者： Danijela Ristic-Medic Snjezana Petrovic Aleksandra Arsic Vesna Vucic Group for Nutritional Biochemistry and Dietology Centre of Research Excellence in Nutrition and MetabolismNational Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2).In general,oxidative stress is actively involved in initiation and progression of liver *** liver metabolizes various compounds that produce free *** the oxidative/antioxidative balance is important in coronavirus disease 2019(COVID-19)*** vitamins,essential trace elements and food compounds,such as polyphenols,appear to be promising agents,with effects in oxidative *** of these nutrients suppresses immune function and increases susceptibility to *** micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary *** supplements(β-carotene,vitamin A,vitamin C,vitamin E,and selenium)could have a potential role in patients with liver *** evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of *** trials based on the associations of diet and SARS-CoV-2 infection are ***,it is not possible to definitively determine the dose,route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still *** then,hopefully,this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Liver injury Antioxidants Nutrients Treatment

Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

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World Journal of Stem Cells 2021年第11期13卷 1696-1713页

作者： Jelena Krstić Slavko Mojsilović Sonja S Mojsilović Juan F Santibanez Gottfried Schatz Research Center Medical University of GrazGraz 8010Austria Group for Hematology and Stem Cells Institute for Medical ResearchNational Institute of Republic of SerbiaUniversity of BelgradeBelgrade 11129Serbia Group for Immunology Institute for Medical ResearchNational Institute of Republic of SerbiaBelgrade 11129Serbia Group for Molecular Oncology Institute for Medical ResearchNational Institute of Republic of SerbiaUniversity of BelgradeBelgrade 11000Serbia Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsChile 8370993Chile

Bone regeneration is a tightly regulated process that ensures proper repair and functionality after *** delicate balance between bone formation and resorption is governed by cytokines and signaling molecules released during the inflammatory ***(IL)-17A,produced in the early phase of inflammation,influences the fate of *** to their inherent capacity to differentiate into osteoblasts,mesenchymal stem/stromal cells(MSCs)contribute to bone healing and *** review presents an overview of IL-17A signaling and the leading cellular and molecular mechanisms by which it regulates the osteogenic differentiation of *** main findings demonstrating IL-17A’s influence on osteoblastogenesis are *** this end,divergent information exists about the capacity of IL-17A to regulate MSCs’osteogenic fate,depending on the tissue context and target cell type,along with contradictory findings in the same cell ***,we summarize the data showing both the pro-osteogenic and anti-osteogenic roles of IL-17,which may help in the understanding of IL-17A function in bone repair and regeneration.

关键词： Interleukin-17 Mesenchymal stem cells Osteoblast Bone Osteogenesis Inflammation

Association between innate immunity gene polymorphisms and neonatal sepsis development:a systematic review and meta-analysis

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World Journal of Pediatrics 2022年第10期18卷 654-670页

作者： Tamara Sljivancanin Jakovljevic Jelena Martic Jelena Jacimovic Nadja Nikolic Jelena Milasin Tanja Lazić Mitrović Department of Neonatology The Obstetrics and Gynecology Clinic“Narodni Front”BelgradeSerbia School of Medicine University of BelgradeBelgradeSerbia Department of Neonatology Mother and Child Health Care Institute of Serbia“Dr Vukan Cupic”BelgradeSerbia Central Library School of Dental MedicineUniversity of BelgradeBelgradeSerbia Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgradeSerbia

Background The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis *** A comprehensive literature search,reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-S guidelines,was performed with no language *** derived using the PICO(population,intervention,comparison and outcomes)strategy,with data on the genotype distribution for innate immunity gene polymorphisms in newborns with and without *** were analyzed using Review *** Cochran–Mantel–Haenszel test was used to calculate odds ratios with 95%confidence *** was tested using the I2 *** From a total of 9428 possibly relevant articles,33 qualified for inclusion in this systematic *** to the STrengthening the REporting of Genetic Association Studies,23 studies were found to be of moderate quality,while 10 were of low *** results showed an association of the mannose-binding lectin(MBL)exon 1 genetic polymorphism with the risk of culture-proven ***-like receptor(TLR)4 rs4986791 genotype distribution suggests its association with the increased risk of culture-proven *** certainty of evidence per GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)varied from very low to *** bias was not *** Out of the 11 investigated single-nucleotide polymorphisms,this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 *** is an evident need for larger well-designed,multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.

关键词： Genetic Immunity Innate Neonatal sepsis Polymorphism

Photometric Analysis of Three Potential Red Nova Progenitors

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Research in Astronomy and Astrophysics 2022年第10期22卷 103-110页

作者： Surjit S.Wadhwa Ain De Horta Miroslav D.Filipovic N.F.H.Tothill Bojan Arbutina Jelena Petrovic Gojko Djurasevic School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Astronomy Faculty of MathematicsUniversity of BelgradeStudentski trg 1611000 BelgradeSerbia Astronomical Observatory Volgina 711060 BelgradeSerbia

We present photometric analysis of three bright red nova progenitor contact binary systems:ASAS J082151-0612.6,TYC 7281-269-1 and TYC *** primary components in all three systems are solar-type low mass stars with radii somewhat larger than their zero age main sequence *** secondaries,as in most contact binary systems,have radii and luminosities well above their main sequence *** three have extremely low mass ratios ranging from 0.075 to 0.097 and two have high degrees of contact,in excess of 75%.All three have mass ratios and separations below the theoretical values for orbital *** activity,a hallmark of magnetic activity and magnetic braking,considered important in mediating angular momentum loss,is also *** three systems demonstrate the O’Connell effect,and all systems require the introduction of star spots for a better light curve *** addition,we show that ASAS J082151-0612.6 and TYC 7281-269-1 have a UV color excess in the range indicating high chromospheric *** measure of potential significant magnetic activity is X-ray luminosity;TYC 7275-1968-1 and probably also TYC 7281-269-1 have X-ray luminosity well above other contact binary *** conclude that it is likely that all three are unstable and hence are potential merger candidates.

关键词： (stars:)binaries eclipsing-techniques photometric-stars low-mass

SOX transcription factors and glioma stem cells:Choosing between stemness and differentiation

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World Journal of Stem Cells 2021年第10期13卷 1417-1445页

作者： Milena Stevanovic Natasa Kovacevic-Grujicic Marija Mojsin Milena Milivojevic Danijela Drakulic Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeBelgrade 11042Serbia Chair Biochemistry and Molecular Biology Faculty of BiologyUniversity of BelgradeBelgrade 11158Serbia Department of Chemical and Biological Sciences Serbian Academy of Sciences and ArtsBelgrade 11000Serbia

Glioblastoma(GBM)is the most common,most aggressive and deadliest brain ***,remarkable progress has been made towards understanding the cellular and molecular biology of *** tumor initiation,progression and relapse as well as resistance to treatments are associated with glioma stem cells(GSCs).GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types,generating a range of distinct cell types within the tumor,leading to cellular *** tumors may contain different subsets of GSCs,and some of them may adopt a quiescent state that protects them against chemotherapy and *** enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties,making them more malignant,able to rapidly *** impact of SOX transcription factors(TFs)on brain tumors has been extensively studied in the last *** all SOX genes are expressed in GBM,and their expression levels are associated with patient prognosis and *** SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC *** fine-tuning of SOX gene expression levels controls the balance between cell stemness and ***,innovative therapies targeting SOX TFs are emerging as promising tools for combatting *** GBM has been a demanding and challenging goal for *** current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient *** approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM.

关键词： Glioblastoma SOX transcription factors Glioma stem cells Stemness Differentiation

Structural changes of proteins in liver cirrhosis and consequential changes in their function

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World Journal of Gastroenterology 2022年第29期28卷 3780-3792页

作者： Nikola Gligorijevic Simeon Minic Olgica Nedic Department of Metabolism University of Belgrade-Institute for the Application of Nuclear EnergyBelgrade 11080S Centre of Excellence for Molecular Food Sciences and Department of Biochemistry University of Belgrade-Faculty of ChemistryBelgrade 11000Serbia

The liver is the site of synthesis of the majority of circulating *** initial polypeptide synthesis,sophisticated machinery is involved in the further processing of proteins by removing parts of them and/or adding functional groups and small molecules tailoring the final molecule to suit its physiological *** modifications(PTMs)design a network of molecules with the common protein ancestor but with slightly or considerably varying activity/localization/*** can change under pathological conditions,giving rise to aberrant or overmodified *** changes in the structure of proteins most often accompany undesired changes in their function,such as reduced activity or the appearance of new *** protein processing is essential for the reactions in living beings and crucial for the overall quality *** that occur on proteins synthesized in the liver whose PTMs are cirrhosis-related are oxidation,nitration,glycosylation,acetylation,and *** of them predominantly affect proteins that remain in liver cells,whereas others predominantly occur on proteins that leave the liver or originate from other tissues and perform their function in the *** PTMs of certain proteins are potential candidates as biomarkers of liver-related diseases,including *** review will focus on PTMs on proteins whose structural changes in cirrhosis exert or are suspected to exert the most serious functional consequences.

关键词： Liver cirrhosis Post-translational modifications Circulation Protein function Protein structure Chronic liver disease

Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential

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BIOCELL 2021年第6期45卷 1543-1550页

作者： MAJA MILOSEVIC MILOS LAZAREVIC BOSKO TOLJIC MILAN PETROVIC MIROSLAV VUKADINOVIC ZORAN JEZDIC BOBAN ANICIC DRAGO JELOVAC SVETLANA JOVANOVIC JELENA MILASIN Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia Clinic for Maxillofacial Surgery School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia Department of Public Health School of Dental MedicineUniversity of BelgradeBelgrade11000Serbia

Specific cell subpopulations identified as cancer stem cells(CSCs)can be found in basal cell carcinoma(BCC).Generally,CSCs have a marked trans-differentiation potential that could potentially be used in differentiation ***,there are no studies regarding BCC CSCs *** aim of the study was to analyze the characteristic of CSCs of BCC with emphasis on their differentiation potential upon specific *** staining and cell morphology were used for differentiation confirmation,along with the expression analysis of osteogenic(ALP,BSP,Runx2,OCN,BMP2),chondrogenic(COL1 and COL2A1),adipogenic(PPAR-γ)and neurogenic(Nestin and MAP2)*** CSCs differentiated into osteogenic and chondrogenic lineages,as judged by staining and high expression of specific markers(from 2-to 92-fold higher upon induction).Concomitantly with differentiation,the levels of cancer stem cell markers decreased in the ***-differentiation and neuro-differentiation were *** conclusion,BCC CSCs exhibit the capacity to trans-differentiate,a characteristic that may potentially be useful in the development of new strategies for the treatment of aggressive BCCs.

关键词： Basal cell carcinoma Cancer stem cells Differentiation potential Osteo-differentiation Chondro-differentiation

Effect of temperature on mudstone disintegration process revealed with image analysis

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Journal of Mountain Science 2022年第7期19卷 2126-2135页

作者： YAN Luo-bin Srdjan PETROVIC HUANG Cheng XIE Chun-xia ZONG Hui-ming Milica KASANIN-GRUBIN School of Geographical Sciences Southwest UniversityChongqing400715China Danxia Landscape Research Institute Shaoguan512330China Institute of Chemistry Technology and MetallurgyDepartment of Catalysis and Chemical Engineering and Center for Environmental Chemistry and EngineeringUniversity of BelgradeBelgrade11000Serbia School of Geographical and Planning Sun Yat-sen UniversityGuangzhou410275China

Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment *** proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering *** artificial models were designed to select suitable metrics among over 20 *** validate the efficiency of image analysis,we analyzed rocks from badlands in Nanxiong Basin,Southeast China,under three different ranges of temperature differences(TD)during cyclic wetting and drying(WD).Our results show that TDs can accelerate the disintegration rate,and even if there is only a 20℃ difference in the range of TDs,an apparent difference in fragment size was ***,the shape of fragments became more round as the increasing number of cyclic treatments,and for samples that went through the same number of treatments,the larger the temperature difference,the more round the shape *** that serves as another evidence for landscape evolution response to climatic warming.

关键词： Mechanical weathering Temperature effect Quantifying weathering rates Fragment size Fragment shape

Retinoic acid affects basic cellular processes and SOX2 and SOX18 expression in breast carcinoma cells

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BIOCELL 2021年第5期45卷 1355-1367页

作者： ISIDORA PETROVIC MILENA MILIVOJEVIC ANA ARSENIJEVIC ANDRIJANA LAZIC NATASA KOVACEVIC GRUJICIC MARIJA SCHWIRTLICH JELENA POPOVIC MILENA STEVANOVIC Institute of Molecular Genetics and Genetic Engineering University of BelgradeBelgradeSerbia Institute of Cell Biology School of Biological SciencesThe University of EdinburghEdinburghUK Department of Radiation Oncology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Faculty of Biology University of BelgradeBelgradeSerbia Serbian Academy of Sciences and Arts BelgradeSerbia

Genetic and molecular heterogeneity,together with intrinsic and acquired resistance to therapy,represent the major obstacles to the successful treatment of different types of breast *** evidence demonstrates that SOX transcription factors in breast carcinomas could act both as oncogenes and tumor suppressors and have been associated with tumor stage and grade,poor prognosis,and therapy *** SOX2 and SOX18 overexpression has been correlated with poor prognosis in breast carcinomas,and these genes are recognized as potential antitumor *** aim was to evaluate the effect of retinoic acid(RA),a well-known cyto-differentiating agent,on breast carcinoma cells in vitro and to investigate the potential of RA treatment to modify the expression of SOX2 and SOX18 *** applying various experimental approaches,we evaluated the effect of RA on basic cellular processes in SK-BR-3 and MCF7 breast carcinoma cell *** have shown that RA inhibits cell growth,reduces the number of Ki-67 positive cells,and causes cell-cycle *** effect was more prominent in SK-BR-3 cell line that lacks SOX2 expression,including a higher decrease in cell viability,reduction in colony formation,and significant remodeling of cellular *** have shown that RA treatment led to the downregulation of SOX2 expression in MCF7 cells and to the reduction of SOX18 expression in both cell *** functional analysis,we showed that the anti-proliferative effect of RA in both cell lines was not based on the activity of stemness marker SOX2,pointing to a SOX2-independent mechanism of *** ability of RA to reduce SOX2/SOX18 expression raises the possibility that these genes can be used as biomarkers to distinguish RA-responders from ***,our study shows that the response of breast carcinoma cell lines to RA treatment may vary,highlighting that the development of RA-based therapy should consider differences in breast carcinoma subtypes.

关键词： Breast carcinoma Anti-proliferative activity Transcription factors MCF7 cell line SK-BR-3 cell line