Structural changes of proteins in liver cirrhosis and consequential changes in their function
作者机构：Department of MetabolismUniversity of Belgrade-Institute for the Application of Nuclear EnergyBelgrade 11080S Centre of Excellence for Molecular Food Sciences and Department of BiochemistryUniversity of Belgrade-Faculty of ChemistryBelgrade 11000Serbia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第29期
页 面：3780-3792页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Ministry of Education Science and Technological Development of the Republic of Serbia No.451-03-9/2021-14/200019
主 题：Liver cirrhosis Post-translational modifications Circulation Protein function Protein structure Chronic liver disease
摘 要：The liver is the site of synthesis of the majority of circulating *** initial polypeptide synthesis,sophisticated machinery is involved in the further processing of proteins by removing parts of them and/or adding functional groups and small molecules tailoring the final molecule to suit its physiological *** modifications(PTMs)design a network of molecules with the common protein ancestor but with slightly or considerably varying activity/localization/*** can change under pathological conditions,giving rise to aberrant or overmodified *** changes in the structure of proteins most often accompany undesired changes in their function,such as reduced activity or the appearance of new *** protein processing is essential for the reactions in living beings and crucial for the overall quality *** that occur on proteins synthesized in the liver whose PTMs are cirrhosis-related are oxidation,nitration,glycosylation,acetylation,and *** of them predominantly affect proteins that remain in liver cells,whereas others predominantly occur on proteins that leave the liver or originate from other tissues and perform their function in the *** PTMs of certain proteins are potential candidates as biomarkers of liver-related diseases,including *** review will focus on PTMs on proteins whose structural changes in cirrhosis exert or are suspected to exert the most serious functional consequences.
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