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Reabsorption of intervertebral disc prolapse after conservative treatment with traditional Chinese medicine:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2308-2314页

作者： Cong-An Wang Hong-Fei Zhao Jing Ju Li Kong Cheng-Jiao Sun Yue-Kun Zheng Feng Zhang Guang-Jian Hou Chen-Chen Guo Sheng-Nan Cao Dan-Dan Wang Bin Shi Postdoctoral Mobile Station of shandong University of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Bone Biomechanics Engineering Laboratory of shandong province Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical UniversityShandong First Medical University and Shandong Academy of Medical SciencesJinan 250014Shandong ProvinceChina School of Acupuncture-Tuina Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Weihai Hospital of Traditional Chinese Medicine Weihai 264200Shandong ProvinceChina Department of Intensive Care Medicine The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011Shandong ProvinceChina Huantai County Hospital of Traditional Chinese Medicine Zibo 256400Shandong ProvinceChina shandong University of Traditional Chinese Medicine School of Acupuncture-TuinaJinan 250014Shandong ProvinceChina shandong First Medical University and shandong Academy of Medical sciences Neck-Shoulder and Lumbocrural Pain HospitalShandong Medicinal Biotechnology CenterJinan 250062Shandong ProvinceChina

BACKGROUND Conservative treatments have been reported to diminish or resolve clinical symptoms of lumbar intervertebral disc herniation(LIDH)within a few *** SUMMARY Computed tomography and magnetic resonance imaging(MRI)of the lumbar region of a 25-yearold male diagnosed with LIDH showed prolapse of the L5/S2 *** disc extended 1.0 cm beyond the vertebral edge and hung along the posterior vertebral *** patient elected a conservative treatment regimen that included traditional Chinese medicine(TCM),acupuncture,and *** a follow-up period of more than 12 mo,good improvement in pain was reported without *** of the lumbar region after 12 mo showed obvious reabsorption of the *** A conservative treatment regimen of TCM,acupuncture,and massage promoted reabsorption of a prolapsed disc.

关键词： Intervertebral disc degeneration Traditional Chinese medicine Reabsorption Acupuncture Massage Case report

Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells:Role of cystathionineγ-lyase/hydrogen sulfide pathway

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World Journal of Stem Cells 2023年第11期15卷 1017-1034页

作者： Bin Hu Xiang-Xi Zhang Tao Zhang Wan-Cheng Yu Department of Cardiovascular Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250062Shandong ProvinceChina

BACKGROUND Ferroptosis can induce low retention and engraftment after mesenchymal stem cell(MSC)delivery,which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension(PAH)***,the cystathionineγ-lyase(CSE)/hydrogen sulfide(H_(2)S)pathway may contribute to mediating ***,the influence of the CSE/H_(2)S pathway on ferroptosis in human umbilical cord MSCs(HUCMSCs)remains *** To clarify whether the effect of HUCMSCs on vascular remodelling in PAH mice is affected by CSE/H_(2)S pathway-mediated ferroptosis,and to investigate the functions of the CSE/H_(2)S pathway in ferroptosis in HUCMSCs and the underlying *** Erastin and ferrostatin-1(Fer-1)were used to induce and inhibit ferroptosis,*** were transfected with a vector to overexpress or inhibit expression of CSE.A PAH mouse model was established using 4-wk-old male BALB/c nude mice under hypoxic conditions,and pulmonary pressure and vascular remodelling were *** survival of HUCMSCs after delivery was observed by in vivo bioluminescence *** viability,iron accumulation,reactive oxygen species production,cystine uptake,and lipid peroxidation in HUCMSCs were ***-related proteins and S-sulfhydrated Kelchlike ECH-associating protein 1(Keap1)were detected by western blot *** In vivo,CSE overexpression improved cell survival after erastin-treated HUCMSC delivery in mice with hypoxiainduced *** vitro,CSE overexpression improved H_(2)S production and ferroptosis-related indexes,such as cell viability,iron level,reactive oxygen species production,cystine uptake,lipid peroxidation,mitochondrial membrane density,and ferroptosis-related protein expression,in erastin-treated *** contrast,in vivo,CSE inhibition decreased cell survival after Fer-1-treated HUCMSC delivery and aggravated vascular remodelling in PAH *** vitro,CSE inhibition decreased H_(2)S levels and

关键词： Human umbilical cord mesenchymal stem cells Cystathionineγ-lyase/hydrogen sulfide pathway Ferroptosis Pulmonary arterial hypertension S-sulfhydration

Underlying mechanisms and clinical potential of circRNAs in glioblastoma

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Oncology Research 2023年第4期31卷 449-462页

作者： LEI ZHANG YUAN ZHANG HUIJUAN GAO XIN LI PEIFENG LI Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266021China

Glioblastoma(GBM)is the most malignant form of glioma and is difficult to diagnose,leading to high mortality *** RNAs(circRNAs)are noncoding RNAs with a covalently closed loop *** are involved in various pathological processes and have been revealed to be important regulators of GBM *** exert their biological effects by 4 different mechanisms:serving as sponges of microRNAs(miRNAs),serving as sponges of RNA binding proteins(RBPs),modulating parental gene transcription,and encoding functional *** the 4 mechanisms,sponging miRNAs is *** good stability,broad distribution and high specificity make circRNAs promising biomarkers for GBM *** this paper,we summarized the current understanding of the characteristics and action mechanisms of circRNAs,illustrated the underlying regulatory mechanisms of circRNAs in GBM progression and explored the possible diagnostic role of circRNAs in GBM.

关键词： CircRNAs GBM Underlying mechanisms Clinical value

Derivation of Benzothiadiazine-1,1-dioxide Scaffolds via Transition Metal-Catalyzed C-H Activation/Annulation

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Chinese Journal of Chemistry 2023年第16期41卷 1973-1978页

作者： Ruizhi Lai Shuran Xu Qingyao Zhang Hui Zhou Cankun Luo Yuerong Wang Li Hai Yong Wu Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmagySichuan UniversityChengduSichuan 610041China

Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and *** of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C—H activation/annulation was reported.3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate,and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents,*** strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner.

关键词： C-H activation Annulation Ruthenium Rhodium Heterocycles Fused-ring systems Spiro compounds Diazo compounds

Strategies to overcome drug resistance using SHP2 inhibitors

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3908-3924页

作者： Meng Liu Shan Gao Reham M.Elhassan Xuben Hou Hao Fang School of Pharmaceutical sciences Cheeloo College of MedicineShandong UniversityJinan 250012China

Encoded by PTPN11,the SHP2(Src homology-2 domain-containing protein tyrosine phosphatase-2)is widely recognized as a carcinogenic *** a promising anti-cancer drug target,SHP2 regulates many signaling pathways such as RAS-RAF-ERK,PI3 K-AKT and ***,SHP2 plays a significant role in regulating immune cell function in the tumor ***,five SHP2 allosteric inhibitors have been recruited in clinical studies for the treatment of *** recently,studies have proved the therapeutic potential of SHP2 inhibitor in overcoming drug resistance of kinase inhibitors and programmed cell death-1(PD-1)***,we review the structure,function and small molecular inhibitors of SHP2,and highlight recent progress in overcoming drug resistance using SHP2 *** hope this review would facilitate the future clinical development of SHP2 inhibitors.

关键词： SHP2 inhibitor Allosteric inhibitor Anti-cancer Drug resistance

Percutaneous transhepatic intraportal biopsy using gastroscope biopsy forceps for diagnosis of a pancreatic neuroendocrine neoplasm:A case report

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World Journal of Gastroenterology 2023年第7期29卷 1235-1242页

作者： Guang-Chuan Wang Guang-Jun Huang Chun-Qing Zhang Qian Ding Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Pancreatic neuroendocrine neoplasms(PNENs)are a rare group of neoplasms originating from the islets of the *** vein tumor thrombosis has been reported in 33%of patients with *** the histopathological diagnosis of PNENs is usually based on percutaneous biopsy or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA),these approaches may be impeded by gastric varices,poor access windows,or anatomically contiguous critical *** a pathological diagnosis using a gastroscope biopsy forceps via percutaneous transhepatic intravascular pathway is an innovative method that has rarely been *** SUMMARY A 72-year-old man was referred to our hospital for abdominal pain and *** contrast-enhanced magnetic resonance imaging revealed a wellenhanced tumor(size:2.4 cm×1.2 cm×1.2 cm)in the pancreatic tail with portal vein *** pathological diagnosis via EUS-FNA was not possible because of diffuse gastric *** performed a percutaneous transportal biopsy of the portal vein tumor thrombus using a gastroscope biopsy *** examination revealed a pancreatic neuroendocrine neoplasm(G2)with somatostatin receptors 2(+),allowing systemic *** Intravascular biopsy using gastroscope biopsy forceps appears to be a safe and effective method for obtaining a histopathological *** welldesigned clinic trials are required to obtain more definitive evidence,this procedure may help improve the diagnosis of portal vein thrombosis and related diseases.

关键词： Percutaneous transhepatic intravascular biopsy Portal vein tumor thrombosis Gastroscope biopsy forceps Pancreatic neuroendocrine neoplasms Case report

Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells

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World Journal of Stem Cells 2023年第3期15卷 90-104页

作者： Tao Zhang Qian Zhang Wan-Cheng Yu Department of Cardiovascular Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250062Shandong ProvinceChina

BACKGROUND The low survival rate of mesenchymal stem cells(MSCs)caused by anoikis,a form of apoptosis,limits the therapeutic efficacy of *** a proapoptotic molecule,mammalian Ste20-like kinase 1(Mst1)can increase the production of reactive oxygen species(ROS),thereby promoting ***,we found that Mst1 inhibition could protect mouse bone marrow MSCs(mBMSCs)from H 2 O 2-induced cell apoptosis by inducing autophagy and reducing ROS ***,the influence of Mst1 inhibition on anoikis in mBMSCs remains *** To investigate the mechanisms by which Mst1 inhibition acts on anoikis in isolated *** Poly-2-hydroxyethyl methacrylate-induced anoikis was used following the silencing of Mst1 expression by short hairpin RNA(shRNA)adenovirus ***(ITGs)were tested by flow *** and ITGα5β1 were inhibited using 3-methyladenine and small interfering RNA,*** alterations in anoikis were measured by Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling and anoikis *** levels of the anoikis-related proteins ITGα5,ITGβ1,and phospho-focal adhesion kinase and the activation of caspase 3 and the autophagy-related proteins microtubules associated protein 1 light chain 3 II/I,Beclin1 and p62 were detected by Western *** In isolated mBMSCs,Mst1 expression was upregulated,and Mst1 inhibition significantly reduced cell apoptosis,induced autophagy and decreased ROS ***,we found that Mst1 inhibition could upregulate ITGα5 and ITGβ1 expression but not ITGα4,ITGαv,or ITGβ3 ***,autophagy induced by upregulated ITGα5β1 expression following Mst1 inhibition played an essential role in the protective efficacy of Mst1 inhibition in averting *** Mst1 inhibition ameliorated autophagy formation,increased ITGα5β1 expression,and decreased the excessive production of ROS,thereby reducing cell apoptosis in isolated *** on these results,Mst

关键词： Mouse bone marrow mesenchymal stem cell Mammalian sterile 20-like kinase 1 Anoikis Integrin Autophagy Reactive oxygen species

PTGS2 identified as a biomarker of glucocorticoid-induced osteonecrosis of the femoral head and an enhancer of osteogenesis

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Genes & Diseases 2023年第1期10卷 14-17页

作者： Qingyu Zhang Shun Lu Dongsheng Zhou Jun Dong Fanxiao Liu Department of Orthopaedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China

Due to the use of more adjuvant therapies and the increasing prevalence of associated diseases,nontraumatic osteonecrosis of the femoral head(ONFH)has become a substantial worldwide health issue;while glucocorticoid administration was the highest-ranked risk factor,with a proportion ranging from 26.35 to 55.75%.1 Albeit with similar radiological features,glucocorticoid-induced ONFH(GONFH)manifested a greater probability for advance-tolate-stage(post-collapse)lesions in comparison with its non-glucocorticoid-induced counterparts.i1 Therefore,an accurate and timely diagnosis of osteonecrosis following glucocorticoid therapy is of great significance to initiate nonoperative treatment regimens or joint-preserving procedures,slow disease progression,and defer or avert joint arthroplasty.

关键词： glucocorticoid diagnosis operative

Ferroptosis mechanism and Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1741-1750页

作者： Lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun shandong Key Laboratory of TCM Multi-Target Intervention and Disease Control the Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Internal Medicine Taian Traffic HospitalTaianShandong ProvinceChina Department of Neurology the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchunJilin ProvinceChina

Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living *** process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living *** is a classic regulatory mode of cell *** studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s *** review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s *** findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E Fe^(2+) ferroptosis glial cell glutathione peroxidase 4 imbalance in iron homeostasis lipid peroxidation regulated cell death system Xc^(-)