PTGS2 identified as a biomarker of glucocorticoid-induced osteonecrosis of the femoral head and an enhancer of osteogenesis

作     者：Qingyu Zhang Shun Lu Dongsheng Zhou Jun Dong Fanxiao Liu Qingyu Zhang;Shun Lu;Dongsheng Zhou;Jun Dong;Fanxiao Liu

作者机构：Department of OrthopaedicsShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第1期

页      面：14-17页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work was partially supported by the China Scholarship Council(CSC)(No.201808080126) the Incubation Fund of Shandong Provincial Hospital(China)(No.2020FY019) the Young Scholars Program of Shandong Provincial Hospital,the Young Taishan Scholars Program of Shandong Province(China)(No.tsqn201909183) the Academic Promotion Program of Shandong First Medical University(China)(No.2020RC008) the Natural Science Foundation of Shandong Province(China)(No.ZR2020QH072 and ZR2021QH307) 

主　　题：glucocorticoid diagnosis operative 

摘      要：Due to the use of more adjuvant therapies and the increasing prevalence of associated diseases,nontraumatic osteonecrosis of the femoral head(ONFH)has become a substantial worldwide health issue;while glucocorticoid administration was the highest-ranked risk factor,with a proportion ranging from 26.35 to 55.75%.1 Albeit with similar radiological features,glucocorticoid-induced ONFH(GONFH)manifested a greater probability for advance-tolate-stage(post-collapse)lesions in comparison with its non-glucocorticoid-induced counterparts.i1 Therefore,an accurate and timely diagnosis of osteonecrosis following glucocorticoid therapy is of great significance to initiate nonoperative treatment regimens or joint-preserving procedures,slow disease progression,and defer or avert joint arthroplasty.