Ferroptosis mechanism and Alzheimer's disease

作     者：Lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun Lina Feng;Jingyi Sun;Ling Xia;Qiang Shi;Yajun Hou;Lili Zhang;Mingquan Li;Cundong Fan;Baoliang Sun

作者机构：Shandong Key Laboratory of TCM Multi-Target Intervention and Disease Controlthe Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Internal MedicineTaian Traffic HospitalTaianShandong ProvinceChina Department of Neurologythe Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchunJilin ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第8期

页      面：1741-1750页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81501106(to CF) Fund of Taishan Scholar Project(to CF) the Natural Science Foundation of Shandong Province,No.ZR2020QH106(to YH) the Medical and Health Science and Technology Development Plan of Shandong Province,No.202203010799(to QS) 

主　　题：Alzheimer’s disease apolipoprotein E Fe^(2+) ferroptosis glial cell glutathione peroxidase 4 imbalance in iron homeostasis lipid peroxidation regulated cell death system Xc^(-) 

摘      要：Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living *** process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living *** is a classic regulatory mode of cell *** studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s *** review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s *** findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.