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Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1213-1226页

作者： Guo-Le Nie Jun Yan Ying Li Hong-Long Zhang Dan-Na Xie Xing-Wang Zhu Xun Li The first School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT),a complication of liver cirrhosis,is a major public health *** prediction is the most effective method for PVT diagnosis and *** To develop and validate a nomogram and network calculator based on clinical indicators to predict PVT in patients with *** Patients with cirrhosis hospitalized between January 2016 and December 2021 at the first hospital of lanzhou university were screened and 643 patients with cirrhosis who met the eligibility criteria were *** a 1:1 propensity score matching 572 patients with cirrhosis were screened,and relevant clinical data were *** risk factors were identified using the least absolute shrinkage and selection operator(LASSO)and multivariate logistic regression *** inflation factors and correlation matrix plots were used to analyze multicollinearity among the variables.A nomogram was constructed to predict the probability of PVT based on independent risk factors for PVT,and its predictive performance was verified using a receiver operating characteristic curve(ROC),calibration curves,and decision curve analysis(DCA).Finally,a network calculator was constructed based on the *** This study enrolled 286 cirrhosis patients with PVT and 286 without *** analysis revealed 13 variables as strongly associated with PVT *** logistic regression analysis revealed nine indicators as independent PVT risk factors,including etiology,ascites,gastroesophageal varices,platelet count,D-dimer,portal vein diameter,portal vein velocity,aspartate transaminase to neutrophil ratio index,and platelet-to-lymphocyte *** and correlation matrix plot results revealed no significant multicollinearity or correlation among the variables.A nomogram was constructed based on the screened independent risk *** nomogram had excellent predictive performance,with an area under the ROC curve of 0.821 and 0.829 in the

关键词： Portal vein thrombosis Liver cirrhosis Nomogram Inflammatory markers Aspartate aminotransferase to neutrophil ratio index Platelet-to-lymphocyte ratio

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Cancer cachexia:Focus on cachexia factors and inter-organ communication

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Chinese Medical Journal 2024年第1期137卷 44-62页

作者： Yongfei Wang Zikai Dong Ziyi An Weilin Jin The first Clinical Medical College of lanzhou university LanzhouGansu 730000China Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhouGansu 730000China

Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia *** cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer *** cachexia factors are also a potential target for the diagnosis and *** pathogenesis of cachexia is unclear and no clear effective treatment is ***,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently *** the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and *** review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia *** summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.

关键词： Cancer cachexia Cancer cachexia factors Inter-organ communication Tumor ecosystem Tumor microenvironment

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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The first Clinical Medical College of lanzhou university Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

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Research and Discussion on Flipped Classroom Combined with Case-Based Learning in Pharmacoeconomics Teaching

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Journal of Contemporary Educational Research 2024年第4期8卷 120-125页

作者： Xingwen Zhou Zilong Dang Xingdong Wang Chen Chen Zhi Rao Ting Wei Yanping Wang Department of Pharmacy the First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

Objective:To explore the application effect of flipped classroom combined with case-based learning teaching methods in pharmacoeconomics ***:The students majoring in clinical pharmacy in 2019 were selected as the study subjects,and the cost-effectiveness analysis of different dosage forms of Yinzhihuang in the treatment of neonatal jaundice was selected as the teaching *** flipped classroom combined with case-based learning teaching method was used to carry out theoretical teaching to the *** the course,questionnaires were distributed through the Sojump platform to evaluate the teaching ***:The results of the questionnaire showed that 85.71%of the students believed that the flipped classroom combined with case-based learning teaching method was helpful in mobilizing the learning enthusiasm and initiative,and improving the comprehensive application ability of the knowledge of pharmacoeconomics.92.86%of the students think that it is conducive to the understanding and memorization of learning content,as well as the cultivation of teamwork,communication,***:Flipped classroom combined with case-based learning teaching method can improve students’knowledge mastery,thinking skills,and practical application skills,as well as optimize and improve teachers’teaching levels.

关键词： Flipped classroom Case-based learning teaching method Pharmacoeconomics Teaching methods

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Ferroptosis in early brain injury after subarachnoid hemorrhage: review of literature

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中华神经外科杂志(英文) 2024年第2期10卷 134-149页

作者： Kang Junlin Tian Shilai Zhang Lei Yang Gang The first hospital of lanzhou university Lanzhou City Gansu Province China Gansu Provincial hospital Lanzhou City Gansu Province China

Spontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.

关键词： Subarachnoid hemorrhage Early brain injury Ferroptosis Intracranial aneurysm

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Relationship between serum neutrophil gelatinase-associated lipocalin levels and cognitive impairment, anxiety, and depressive symptoms in acute ischemic stroke

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World Journal of Psychiatry 2024年第10期14卷 1467-1473页

作者： You-Quan Gu Xuan Zhou Li-He Yao Qiang Wang Chao-Ning Zhou Zhao-Dong Liu Department of Neurology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Neurology The First Clinical Medical College of Lanzhou UniversityLanzhou 730099Gansu ProvinceChina

BACKGROUND Acute ischemic stroke(AIS)is a significant global health issue with increasing incidence owing to aging populations and rising cardiovascular risk *** addition to physical impairments,AIS frequently leads to neuropsychiatric co-mplications,such as cognitive impairment,anxiety,and depressive symptoms,which adversely affect patients’quality of life and *** ge-latinase-associated lipocalin(NGAL)has emerged as a potential biomarker for various conditions,including *** study investigated the association bet-ween serum NGAL levels at admission and neuropsychiatric complications in patients with *** complications in patients with *** Between January 2022 and December 2023,150 patients with AIS were *** NGAL levels were measured at admission using an enzyme-linked immu-nosorbent *** function was assessed using the Mini-Mental State Examination,while anxiety and depressive symptoms were evaluated using the hospital Anxiety and Depression Scale at *** relationship between serum NGAL levels and cognitive impairment,anxiety,and depressive symptoms was analyzed using multivariate logistic regression,adjusted for potential con-founders of age,sex,body mass index,smoking status,hypertension,diabetes mellitus,dyslipidemia,previous stroke,and stroke *** The mean age of the participants was 65.4±10.2 years,and 58%were *** rates of cognitive impairment,anxiety,and depressive symptoms at discharge were 34.7%,28.0%,and 32.0%,*** NGAL levels were significantly higher in patients with cognitive impairment(median:5.6 ng/mL vs 3.2 ng/mL,P<0.001),anxiety(median:5.1 ng/mL vs 3.5 ng/mL,P=0.002),and depressive symptoms(median:5.4 ng/mL vs 3.3 ng/mL,P<0.001),compared to those without these *** logistic regression analysis showed that higher serum NGAL levels at admission were independently associated with cognitive impairment[odds rat

关键词： Neutrophil gelatinase-associated lipocalin Neuropsychiatric complications Biomarker Acute ischemic stroke Cognitive impairment Anxiety Depressive symptoms

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Treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 389-405页

作者： Hongbin Wei Chunlu Dong Xun Li The first School of Clinical Medicine Lanzhou UniversityLanzhouGansuChina The first hospital of lanzhou university LanzhouGansuChina Key Laboratory Biotherapy and Regenerative Medicine of Gansu Province LanzhouGansuChina Cancer Prevention and Treatment Center of lanzhou university School of Medicine LanzhouGansuChina Hepatopancreatobiliary Surgery Institute of Gansu Province LanzhouGansuChina Clinical Research Center for General Surgery of Gansu Province LanzhouGansuChina

Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of *** suppression and the maintenance of self-tolerance in the tumor microenvironment are essential responses,and these form part of the theoretical foundations of *** this review,we first discuss the tumor microenvironment of HCC,describe immunosuppression in HCC,and review the major biomarkers used to track HCC progression and response to *** then examine antibody-based therapies,with a focus on immune checkpoint inhibitors(ICIs),monoclonal antibodies that target key proteins in the immune response(programmed cell death protein 1,anti-cytotoxic T-lymphocyte associated protein 4,and programmed deathligand 1)which have transformed the treatment of HCC and other *** may be used alone or in conjunction with various targeted therapies for patients with advanced HCC who are receiving first-line treatments or subsequent *** also discuss the use of different cellular immunotherapies,including T cell receptor(TCR)T cell therapy and chimeric antigen receptor(CAR)T cell *** then review the use of HCC vaccines,adjuvant immunotherapy,and oncolytic virotherapy,and describe the goals of future research in the development of treatments for HCC.

关键词： Hepatocellular carcinoma Liver cancer Immunotherapy Vaccines

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Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage

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Reproductive and Developmental Medicine 2024年第3期8卷 169-177页

作者： Hong-Xing Li Yi-Hong Chai Xiao-Hong Sun Xiao-Xia He Ya-Ming Xi The first School of Clinical Medicine Lanzhou UniversityLanzhou 730000China Key Laboratory for Reproductive Medicine and Embryo of Gansu Province Lanzhou 730000China Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000China

The differentiation process from hematopoietic stem cells(HSCs)to mature red blood cells(RBCs)is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal *** is the dynamic journey of HSCs through various functional and phenotypic *** physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility,necessitating precise coordination of transcription factors and epigenetic *** review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid *** encompasses the exploration of transcriptional,post-transcriptional,and post-translational regulatory *** intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid *** findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.

关键词： Hematopoietic stem cells Differentiation Epigenetics Post-translational regulation

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One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China

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Portal Hypertension & Cirrhosis 2024年第2期3卷 116-123页

作者： Jitao Wang Ting Cui Linpeng Zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng Zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi Hebei Provincial Key Laboratory of Cirrhosis&Portal Hypertension Xingtai People's HospitalXingtaiHebeiChina Center of Portal Hypertension Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Department of Interventional Therapy Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Intervention Taiyuan Third People's HospitalTaiyuanShanxiChina Department of Intervention Zhongshan Hospital Affiliated to Fudan UniversityShanghaiChina Department of Interventional Medicine The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdongChina Hepatobiliary and Pancreatic Intervention Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Interventional Vascular Surgery Hunan Provincial People's HospitalChangshaHunanChina Department of Intervention Sixth People's Hospital of ShenyangShenyangLiaoningChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Intervention The Fourth People's Hospital of Qinghai ProvinceXiningQinghaiChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Radiology Shulan(Hangzhou)HospitalHangzhouZhejiangChina Department of Intervention Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Interventional Radiology Fifth Medical Center

Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in *** article aimed to investigate the status of hepatic venous pressure gradient measurement in China in ***:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online *** counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in ***:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured *** average cost of HVPG measurement was 5646.8±2327.9 *** the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy ***:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this *** is still necessary to continue promoting and popularizing this technology in the future.

关键词： application status hepatic vein pressure gradient questionnaire survey

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Protective effects of quercetin against H2O2 induced KGN cells injury

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Traditional Medicine Research 2024年第2期9卷 1-7页

作者： Ning Zhang Hui-Xia Zhang Xiao-Ling Ma Jin-Ni Hong Reproductive Medicine Center Lanzhou University First HospitalLanzhou 730030China Department of Traditional Chinese Medicine Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China

Background:Oxidative stress is one of the key contributors to cellular senescence and ovarian *** has a variety of physiological activities such as *** that hydrogen peroxide can cause oxidative damage to cells,the present study is designed to verify the protective effect of quercetin on human ovarian granulosa tumor cell line under oxidative ***:Cell counting kit-8 and lactate dehydrogenase assays examined cell viability and *** cytometry detected reactive oxygen species *** level was measured to analyze the oxidation *** apoptosis was evaluated by Hoechst 33258 staining,acridine orange/Ethidium Bromide staining and western *** mitochondrial structure was observed under a transmission electron *** membrane integrity was detected by JC-1 staining and western ***:Hydrogen peroxide could induce cell injury,promote reactive oxygen species accumulation,and lead to glutathione *** peroxide also resulted in mitochondrial morphological damage and depolarization,which activate caspase3/9 ***,quercetin could mitigate these ***:Present study found that hydrogen peroxide induced oxidative stress and mitochondrial apoptosis of human ovarian granulosa tumor cell line cells,which could be attenuated by quercetin.

关键词： oxidative stress granulosa cells apoptosis mitochondria quercetin

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