Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage
Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage作者机构：Lanzhou Univ Sch Clin Med 1 Lanzhou 730000 Peoples R China Key Lab Reprod Med & Embryo Gansu Prov Lanzhou 730000 Peoples R China Lanzhou Univ Hosp 1 Dept Hematol Lanzhou 730000 Peoples R China
出 版 物：《REPRODUCTIVE AND DEVELOPMENTAL MEDICINE》 (Reproductive and Developmental Medicine)
年 卷 期：2024年第8卷第3期
页 面：169-177页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Scientific Research Fund of the First Hospital of Lanzhou University [ldyyyn2021-15] Science and technology Fund of Gansu Province [21JR7RA391]
主 题：Hematopoietic stem cells Differentiation Epigenetics Post-translational regulation LONG NONCODING RNAS ERYTHROID-DIFFERENTIATION MESSENGER-RNA CHROMATIN ACCESSIBILITY GENE-EXPRESSION TRANSCRIPTION PROLIFERATION ACETYLATION
摘 要：The differentiation process from hematopoietic stem cells (HSCs) to mature red blood cells (RBCs) is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal differentiation. Erythropoiesis is the dynamic journey of HSCs through various functional and phenotypic stages. The physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility, necessitating precise coordination of transcription factors and epigenetic elements. This review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid lineage. This encompasses the exploration of transcriptional, post-transcriptional, and post-translational regulatory processes. The intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid development. These findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.
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